ArchiveAugust 2013

Clinic Speak: predicting cognitive problems and depression in MS

Are you depressed? Do you have executive dysfunction? #MSBlog #MSResearch #ClinicSpeak “For those us who see a lot of MSers we aware that there is strong link between depression and cognitive dysfunction and that both tend to get worse with increasing MS disability. Therefore this study’s results are not surprising; depression, as measured with the Beck Depression Index, was the...

Electrically Active Stem Cells

Jiang P, Chen C, Liu XB, Selvaraj V, Liu W, Feldman DH, Liu Y, Pleasure DE, Li RA, Deng W. Generation and characterization of spiking and non-spiking oligodendroglial progenitor cells from embryonic stem cells.Stem Cells. 2013 Aug 13. doi: 10.1002/stem.1515. [Epub ahead of print] Pluripotent stem cells (PSCs) have been differentiated into oligodendroglial progenitor cells (OPCs), providing...

American-based scientists tend to big it up.

Fanelli D, Ioannidis JP. US studies may overestimate effect sizes in softer research. Proc Natl Acad Sci U S A. 2013 Aug 26. [Epub ahead of print] Many biases affect scientific research, causing a waste of resources, posing a threat to human health, and hampering scientific progress. These problems are hypothesized to be worsened by lack of consensus on theories and methods, by selective...

CCSVI August

#MSResearch CCSVI Leone C, D Amico E, Cilia S, Nicoletti A, Di Pino L, Patti F. Cognitive impairment and “invisible symptoms” are not associated with CCSVI in MS. BMC Neurol. 2013 Jul;13(1):97. [Epub ahead of print] BACKGROUND:We investigated the association between chronic cerebrospinal venous insufficiency (CCSVI) and cognitive impairment (CI) inmultiple sclerosis (MS). Moreover, we...

Guest post: the postcode lottery

The postcode lottery: join the debate. #MSBlog #MSReseach Thousands of MSers are not getting DMTs or the care and support they need, according to a report launched by UK MS Society. Click here to download the report The MS Society wants equal access for all to treatments. However, not everyone was happy about this approach; the following article explains why. ‘A lottery of treatment and care...

Mesenchymal Stem cells promoting myelination

Jadasz JJ, Kremer D, Göttle P, Tzekova N, Domke J, Rivera FJ, Adjaye J, Hartung HP, Aigner L, Küry P.Mesenchymal stem cell conditioning promotes rat oligodendroglial cell maturation. PLoS One. 2013 Aug 12;8(8):e71814. doi: 0.1371/journal.pone.0071814. Oligodendroglial progenitor/precursor cells (OPCs) represent the main cellular source for the generation of new myelinating oligodendrocytes...

Growing mini brains

Lancaster MA et al. Cerebral organoids model human brain development and microcephaly. Nature (2013) doi:10.1038/nature12517 The complexity of the human brain has made it difficult to study many brain disorders in model organisms, highlighting the need for an in vitro model of human brain development. Here we have developed a human pluripotent stem cell-derived three-dimensional organoid culture...

Tremor and deep brain stimulation

DBS or deep brain stimulation for MS tremor. #MSBlog #MSResearch “This is a follow-on post from my recent ClinicSpeak post on tremor and describes a study on the effectiveness of deep brain stimulation on severe MS-related tremor. The results are what they are and should be interpreted in the light of how disabled these MSers are. In short DBS improved self-care (feeding, hygiene...

CD8 killers

Sauer BM, Schmalstieg WF, Howe CL. Axons are injured by antigen-specific CD8+ T cells through a MHC class I – and granzyme B-dependent mechanism. Neurobiol Dis. 2013 Jul 27. doi:pii: S0969-9961(13)00204-0. 10.1016/j.nbd.2013.07.010. [Epub ahead of print] Axon injury is a central determinant of irreversible neurological deficit and disease progression in patients with multiple sclerosis (MS)...

What do YOU call a Neurologist?

I am currently doing yet another poll on the description of someone with MS and maybe will use this at ECTRIMS.  The question is….How do you prefer to be labelled/described?.  Some of the the terms you think are OK and some you think are pretty poor. I will talk about this soon. However, as an exercise in reverse. I ask you ….What we should call someone who treats a...

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