Less spasticity makes you feel better

Arroyo R, Massana M, Vila C. Correlation between Spasticity and Quality of Life in Patients with Multiple Sclerosis: the CANDLE Study. Int J Neurosci. 2013. [Epub ahead of print]

Background: Spasticity is a common symptom in multiple sclerosis (MS) that increases the burden of disease. This study investigated the relationship between the degree of spasticity and patients’ health-related quality of life (QoL). 

Methods: Epidemiological, multicentre, cross-sectional study in patients with MS spasticity. The SF-12 questionnaire was used to assess QoL. The modified Ashworth scale and a 0-10 Numerical Rating Scale (NRS) were used to assess spasticity severity. 

Results: Data were analysed for 409 MS patients with spasticity from 53 neurology clinics in Spain. Mean age was 46.4 (± 11.0) years; 62.4% were women. Most patients had relapsing-remitting MS (42.1%) or secondary progressive MS (43.9%). Mean time since MS diagnosis was 12.5 (± 7.4) years and mean time since first spasticity symptoms was 6.1 (± 4.8) years. 71.3% of patients were being treated pharmacologically for spasticity. Moderate to severe spasticity was measured in 59.2% of patients according to the modified Ashworth scale and in 83.4% according to the NRS. Mean scores for the 0-100 Physical Component Summary and Mental Component Summary subscales of the SF-12 questionnaire were 31.0 (± 9.3) and 45.4 (± 12.0), respectively. Scores on the SF-12 correlated significantly with scores on both spasticity scales (p ≤ 0.002) but the correlation was stronger with the NRS across all domains. 
Conclusions: The results confirm an association between spasticity severity and QoL in patients with MS. The correlation between 0-10 NRS scores and QoL was stronger than that between modified Ashworth scale scores and QoL.
The less spasticity you have the better you feel. We have been found three new classes of drugs that may be useful for treating spasticity plus one that we have made ourselves and show reach humans very soon.
CoI, We have developing  a new spasticity drug

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    • True but it shows the importance of developing better treatments for spasticity (a major research interest of ours) as the current ones ain't great.As MD says due to our efforts, great strides are being made in what has been a Cinderella area for far too long.

  • Drugs are not always the answer. Looked around for alternatives and found some ( RCT but small sample) for acupuncture and whole body vibration therapy. I have had reservations about acupuncture however, first treatment for pain relief and spasticity was astounding for pain relief, instantaneous and spasm less. The evidence for vibration therapy is stronger, added bonus is muscle strength. The most tested machine is the Powerplate – 15 second bursts – if ambulant need to be instructed – it is very powerful, can feel it through the floor at the opposite end of the gym. I've trained with an Aussie paralympian who uses it for spasticity as do some other MSers ambulant and non ambulant. Perhaps Mouse might like the sensation of the earth moving for him.

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