ArchiveAugust 2013

Finding a marker of Risk of PML

#MSResearch #MSblog CD62L levels in blood a risk marker for PML Schwab N, Schneider-Hohendorf T, Posevitz V, Breuer J, Göbel K, Windhagen S, Brochet B, Vermersch P, Lebrun-Frenay C, Posevitz-Fejfár A, Capra R, Imberti L, Straeten V, Haas J, Wildemann B, Havla J, Kümpfel T, Meinl I, Niessen K, Goelz S, Kleinschnitz C, Warnke C, Buck D, Gold R, Kieseier BC, Meuth SG, Foley J, Chan A, Brassat D...

Head Trauma and Multiple sclerosis

Warren SA, Olivo SA, Contreras JF, Turpin KV, Gross DP, Carroll LJ, Warren KG. Traumatic injury and multiple sclerosis: a systematic review and meta-analysis. Can J Neurol Sci. 2013; 40(2):168-76. A systematic review/meta-analysis of literature addressing a possible association between traumatic injury and onset of multiple sclerosis was conducted. Medline, Embase, Cochrane DSR, Ovid...

Pilates and MS

Guclu-Gunduz A, Citaker S, Irkec C, Nazliel B, Batur-Caglayan HZ. The effects of pilates on balance, mobility and strength in patients with multiple sclerosis.NeuroRehabilitation. 2013  [Epub ahead of print] BACKGROUND: Although there are evidences as to Pilates developing dynamic balance, muscle strength and flexibility in healthy people, evidences related to its effects on Multiple...

Immunological differences between NMO and MS

Michael BD, Elsone L, Griffiths MJ, Faragher B, Borrow R, Solomon T, Jacob A. Post-acute serum eosinophil and neutrophil-associated cytokine/chemokine profile can distinguish between patients with neuromyelitis optica and multiple sclerosis; and identifies potential pathophysiological mechanisms – A pilot study. Cytokine. 2013 . doi:pii: S1043-4666(13)00634-0. 10.1016/j.cyto.2013.07.019...

Improving tysabri

Wright E, Rahgozar K, Hallworth N, Lanker S, Carrithers MD. Epithelial v-like antigen mediates efficacy of anti-alpha4 integrin treatment in a mouse model of multiple sclerosis.PLoS One. 2013 Aug 8;8(8):e70954. doi: 10.1371/journal.pone.0070954 Natalizumab inhibits the transmigration of activated T lymphocytes into the brain and is highly efficacious in multiple sclerosis (MS). However, from...

Sodium accumulates in Progressive MS

Maarouf A, Audoin B, Konstandin S, Rico A, Soulier E, Reuter F, Le Troter A, Confort-Gouny S, Cozzone PJ, Guye M, Schad LR, Pelletier J, Ranjeva JP, Zaaraoui W. Topography of brain sodium accumulation in progressive multiple sclerosis. MAGMA. 2013 Aug 3. [Epub ahead of print] OBJECT: Sodium accumulation is involved in neuronal injury occurring in multiple sclerosis (MS). We aimed to assess sodium...

Vitamin D treatment in Rats

Adzemovic MZ, Zeitelhofer M, Hochmeister S, Gustafsson SA, Jagodic M. Efficacy of vitamin D in treating multiple sclerosis-like neuroinflammation depends on developmental stage. Exp Neurol. 2013 Aug 13. doi:pii: S0014-4886(13)00242-2. 10.1016/j.expneurol.2013.08.002. [Epub ahead of print] The association of vitamin D deficiency with higher prevalence, relapse rate and progression of...

What’s relapsing Progressive MS

Relapsing progressive MS is progressive MS with Relapses on Top. This element seems to respond to DMT that treat classical Relapsing MS. Relapsing Secondary Progressive is relapses superimposed on Secondary Progression. These are more uncommon that standard PP and SPP MS 

Question Time Coming to ECTRIMS 2013

What is MS Question Time. It is a based on the BBC Question time where an audience get to ask politicians topical questions.   For MS Question Time the questions are posed by MSers  The panel is being assembled for an International List of MS experts Here is a (Team G) example   We need the questions. You have plenty of time to think and we won’t be able to do them all as we...

The Chalk and Cheese of CCSVI

#MSResearch #MS Blog CCSVI debunked Rodger IW et al. Evidence against the Involvement of Chronic Cerebrospinal Venous Abnormalities in Multiple Sclerosis. A Case-Control Study.PLoS ONE 8(8): e72495. doi:10.1371/journal.pone.0072495 Objective.Multiple sclerosis (MS) is a chronic neurodegenerative disease of the CNS. Recently a controversial vascular hypothesis for MS, termed chronic cerebrospinal...

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