Endogenous viruses may be involved in MS

Nissen KK, Laska MJ, Hansen B, Terkelsen T, Villesen P, Bahrami S, Petersen T, Pedersen FS, Nexø BA .Endogenous retroviruses and multiple sclerosis–new pieces to the puzzle.BMC Neurol. 2013;13(1):111. [Epub ahead of print]

The possibility that retroviruses play a role in multiple sclerosis (MS) has long been considered; accumulating findings suggest this to be most likely in the form of human endogenous retroviruses (HERVs). A genetic test series of fifty endogenous retroviral loci for association with MS in Danes showed SNP markers near a specific endogenous retroviral locus, HERV-Fc1 located on the X-chromosome, to be positive. Bout Onset MS was associated with the HERV-Fc1 locus, while a rarer form, Primary Progressive MS, was not. Moreover, HERV-Fc1 gag RNA in plasma was increased 4-fold in patients with recent history of attacks, relative to patients in a stable state and to healthy controls.Finally, genetic variations in restriction genes for retroviruses influence the risk of MS, providing further support for a role of retroviral elements in disease.We speculate that endogenous retroviruses may activate the innate immune system in a variety of ways, involving the host proteins, Observations in HIV-positive patients suggest that anti-retroviral drugs can curb MS. Thus, these new findings regarding the aetiology and pathogenesis of MS, suggest alternative ways to challenge autoimmune diseases.

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  • I doubt it i do not think of ppms as a different disease.
    The previso is that nmo and ms were thought to be part of the same disease spectrum.

  • " Observations in HIV-positive patients suggest that anti-retroviral drugs can curb MS"

    What are these observations? People with both MS and HIV receiving anti viral drugs? Oder was?

  • The endogenous retrovirus theory raises many questions for the virologists: Will retroviral elements or retroviral DNA introduced into a host with the appropriate HLA phenotype and with the appropriate trigger initiate disease? Direct cause and effect in activating innate immunity. Lots of interesting questions for the project

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