Endogenous viruses may be involved in MS

E
Nissen KK, Laska MJ, Hansen B, Terkelsen T, Villesen P, Bahrami S, Petersen T, Pedersen FS, Nexø BA .Endogenous retroviruses and multiple sclerosis–new pieces to the puzzle.BMC Neurol. 2013;13(1):111. [Epub ahead of print]

The possibility that retroviruses play a role in multiple sclerosis (MS) has long been considered; accumulating findings suggest this to be most likely in the form of human endogenous retroviruses (HERVs). A genetic test series of fifty endogenous retroviral loci for association with MS in Danes showed SNP markers near a specific endogenous retroviral locus, HERV-Fc1 located on the X-chromosome, to be positive. Bout Onset MS was associated with the HERV-Fc1 locus, while a rarer form, Primary Progressive MS, was not. Moreover, HERV-Fc1 gag RNA in plasma was increased 4-fold in patients with recent history of attacks, relative to patients in a stable state and to healthy controls.Finally, genetic variations in restriction genes for retroviruses influence the risk of MS, providing further support for a role of retroviral elements in disease.We speculate that endogenous retroviruses may activate the innate immune system in a variety of ways, involving the host proteins, Observations in HIV-positive patients suggest that anti-retroviral drugs can curb MS. Thus, these new findings regarding the aetiology and pathogenesis of MS, suggest alternative ways to challenge autoimmune diseases.

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MouseDoctor

8 comments

  • I doubt it i do not think of ppms as a different disease.
    The previso is that nmo and ms were thought to be part of the same disease spectrum.

  • " Observations in HIV-positive patients suggest that anti-retroviral drugs can curb MS"

    What are these observations? People with both MS and HIV receiving anti viral drugs? Oder was?

  • The endogenous retrovirus theory raises many questions for the virologists: Will retroviral elements or retroviral DNA introduced into a host with the appropriate HLA phenotype and with the appropriate trigger initiate disease? Direct cause and effect in activating innate immunity. Lots of interesting questions for the project

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