smoking and MS Risk studies from Iran

Asadollahi S, Fakhri M, Heidari K, Zandieh A, Vafaee R, Mansouri B. Cigarette smoking and associated risk of multiple sclerosis in the Iranian population. J Clin Neurosci. 2013 Aug. doi:pii: S0967-5868(13)00182-3. 10.1016/j.jocn.2013.01.018. [Epub ahead of print]

Exposure to cigarette smoke is emerging as an environmental risk factor for multiple sclerosis (MS). We investigated the possible association between environmental tobacco smoke, its cumulative exposure, and MS risk. We used data from the Iranian Multiple Sclerosis Registry to identify a case-control of 662 patients who had MS and a comparison group of 394 patients. Information regarding current smoking status, including the number of cigarettes smoked per day, duration, and smoking pack-years indicative of cumulative dose of tobacco smoked was obtained. We analyzed the incidence of MS among ever-smokers who had been smokers during their disease course and prior to disease onset in comparison with never-smokers who had never been exposed by calculating the odds ratio (OR) with a 95% confidence interval (CI) employing logistic regression. Of the 662 MS patients, there were 523 women (79.0%) and 139 men (21.0%), with a mean age of 31±10.0 years at disease onset. The risk for MS was increased among ever-smokers (OR=1.78, 95% CI=1.22-2.59, p=0.03) compared to never-smokers. As compared with never smokers, the OR for patients with 6-10 pack years was 2.91 for men (95% CI=1.11-9.47, p=0.03) and 1.69 for women (95% CI=1.02-6.45, p=0.04). Our results demonstrate that cigarette smoking is significantly associated with an increased risk for MS. The risk effects of smoking were more noticeable in male patients and at higher tobacco doses

So if you smoke you increase your risk of developing MS, Ths twice compared to non-smokers and 3 times for Iraninan males. Make sure your Kids don’t smoke,it’ll save them loads of cash.

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Leave a Reply to Gavin Giovannoni Cancel reply

  • Smoking and MS puzzles me. Could it be kind of marker?

    " AChEIs, and other cholinergic treatments, such as NICOTINE, possibly could promote myelination during development and myelin repair in older age."

    I have read this on other sites too.

    So could smoking be (maybe) early indicator for MS?

  • I personally would not count smoking as a direct risk factor for MS just an association (as in this famous case of smoking=lung cancer but smokers also drink more so it could be liver cancer). Of course if you smoke like crazy and have a predisposition/faulty immune system then it will increase your risk and make relapses worse but there are thousands of MSers like myself who never smoked and had not been exposed to smoking at all and got MS.

  • I smoked heavily in my youth. I quit decades before I was diagnosed, but I allow I did this to myself.

    But anecdotally, I noticed that most nonsmokers I've met with MS grew up in households with heavy smokers. I wonder if second-hand smoke has ever been measured against likelihood of getting MS.

  • I don't think people should think they have MS because of smoking, it is a lottery. We all know it is bad for our health. We will have to wait a few years to see if the smoking bans across Europe decreases the number of MS sufferers. We are all told to exercise, eat healthily, drink sensibly and not smoke and it will help fend off cancer. I did all these things for a long time. I still got three different cancers. It didn't stop me getting the disease, but I'm sure it helped me fight it.

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