Resveratol is an ingredient in red wine and berries and this study suggests that it makes EAE worse. Will it make the media say that blue berries are going to give you MS.
Fonseca-Kelly Z, Nassrallah M, Uribe J, Khan RS, Dine K, Dutt M, Shindler KS. Resveratrol neuroprotection in a chronic mouse model of multiple sclerosis. Front Neurol. 2012;3:84. doi: 10.3389/fneur.2012.00084.
Shindler KS, Ventura E, Dutt M, Elliott P, Fitzgerald DC, Rostami A. Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. J Neuroophthalmol. 2010;30(4):328-39
Imler TJ Jr, Petro TM. Decreased severity of experimental autoimmune encephalomyelitis during resveratroladministration is associated with increased IL-17+IL-10+ T cells, CD4(-) IFN-gamma+ cells, and decreased macrophage IL-6 expression. Int Immunopharmacol. 2009 Jan;9(1):134-43
Singh NP, Hegde VL, Hofseth LJ, Nagarkatti M, Nagarkatti PResveratrol (trans-3,5,4′-trihydroxystilbene) ameliorates experimental allergic encephalomyelitis, primarily via induction of apoptosis in T cells involving activation of aryl hydrocarbon receptor and estrogen receptor. Mol Pharmacol. 2007;72(6):1508-21
So let’s look at the data and they use between 100mg/kg-1000mg/kg of resveratol which is given orally to the mice to get it to stop EAE….I must admit I do not find the effects that compelling.
Have a look for yourself they are open access. Diminution of EAE by a small bit is not that earth shattering. This does not give me the confidence that resveratol will stop the disease, however it may other desirable effects).
Now think that Red wine has about 0.2-6mg/Litre so if you drink a bottle of wine that is about 1mg/kg so about 100 to 1000 times less than stuff done in mice.
So drinking red wine to get rid of your MS is not going to happen.
Therefore we need to be cautious about how we interpret and use data from the animals.
Does this mean we should stop eating blueberries, I would take this information with “a pince of salt” (=to listen to a story or an explanation with considerable doubt) or maybe not (another dietary misnomer).