Use or Lose it

Booth AJ, Rodgers JD, Schwartz CE, Quaranto BR, Weinstock-Guttman B, Zivadinov R, Benedict RH. Active Cognitive Reserve Influences the Regional Atrophy to Cognition Link in Multiple Sclerosis.J Int Neuropsychol Soc. 2013 Sep 19:1-6. [Epub ahead of print]

Recent research indicates that cognitive reserve mitigates the clinical expression of neuropsychological impairment in multiple sclerosis (MS). This literature primarily uses premorbid intelligence and lifetime experiences as indicators. However, changes in current recreational activities may also contribute to the maintenance of neural function despite brain atrophy. We examined the moderation effects of current changes in recreational activity on the relationship between brain atrophy and information processing speed in 57 relapsing-remitting MS patients. Current enrichment was assessed using the Recreation and Pastimes subscale from the Sickness Impact Profile. In patients reporting current declines in recreational activities, brain atrophy was negatively associated with cognition, but there was no such association in participants reporting stable participation. The MRI metric-by-recreational activity interaction was significant in separate hierarchical regression analyses conducted using third ventricle width, neocortical volume, T2 lesion volume, and thalamic volume as brain measures. Results suggest that recreational activities protect against brain atrophy’s detrimental influence on cognition.

Again another example where keeping your brain active helps maintain brain reserve

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  • Yesterday I underwent the "California Verbal Learning Test" and some other cognitive function test (reaction, attention..)
    And it went very well. I performed at 146% compared to the average NORMAL, HEALTHY ppl.

    So I guess this is a good outcome 😀

    prMS, 3 years from diagnosis, but maybe a history of 17 years of prog.MS.

    • Giovanna used to work in Gavin's team at Queen Square a long time ago as I remember. The study she's just published sounds very exciting.

    • just reading the story in the paper. I is a drug affecting protein misfolding and was tested in prion disease a side effect was weight loss which is a sign of toxicity and diabetes.If this part of the mechanism of action this will be a problemeven thought they say they can dissociate the effext.In ms and eae we have found there is aggrevated protiens so maybe we should have a look.

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