ArchiveNovember 2013

Blog Advent Calendar

Well it is that time of the year again and it is time for the  House of Mouse Advent calendar.   Back by Popular demand! I will be donning new outfits for the latest offering, so I have to thank my Designer Anna (& Previously Naomi) for making such wonderful clothes. In 2011 (for research Day 2012) there was a Christmas Theme and in 2012 (for Research Day 2013) we got to meet TeamG...

CCSVI November

MSResearch#; #CCSVI Trials maybe doomed to fail Kazibudzki M, Latacz P, Ludyga T, Simka M. Efficacy and safety of cutting balloons for the treatment of obstructive lesions in the internal jugular veins. J Cardiovasc Surg (Torino). 2013 Oct 24. [Epub ahead of print] Aim: In this technical note we present the results of endovascular treatment for chronic cerebrospinal venous insufficiency with the...

Animal testing to get even more expensive?

Nathoo N, Yong VW, Dunn JF. Using magnetic resonance imaging in animal models to guide drug development in multiple sclerosis.Mult Scler. 2013 Nov 21. [Epub ahead of print] Major advances are taking place in the development of therapeutics for multiple sclerosis (MS), with a move past traditional immunomodulatory/immunosuppressive therapies toward medications aimed at promoting remyelination or...

Don’t Forget Digesting Science

Our American readers will have been just digested their Thanksgiving Turkey, so don’t to forget to Digest some Science.                                    www.digestingscience.co.uk                             A site for...

Blocking LINGO1 in fish promotes myelination

Yin W, Hu B Knockdown of Lingo1b protein promotes myelination and oligodendrocyte differentiation in zebrafish. Exp Neurol. 2013 Nov. doi:pii: S0014-4886(13)00336-1.10.1016/j.expneurol.2013.11.012. [Epub ahead of print] Demyelinating diseases include multiple sclerosis, which is a neurodegenerative disease characterized by immune attacks on the central nervous system (CNS), resulting in myelin...

Exercise is GOOD:-)

Sá MJ.Exercise therapy and multiple sclerosis: a systematic review. J Neurol. 2013 Nov. [Epub ahead of print] Multiple sclerosis (MS) is an incurable disease, and despite current pharmacologic treatment being effective in reducing relapse rates and lesion burden, there is little evidence that these treatments work as effectively in preventing disability progression. In such cases, non...

Coming Soon!

#MS Research Christmas Cheer/Cheese is coming

As people in the US prepare for Thanksgiving, It is nearly time for Xmas fever as the holiday season is upon us, Guess what’s coming!

Genetic changes in brain areas before the immune cells accumulate

Huynh JL, Garg P, Thin TH, Yoo S, Dutta R, Trapp BD, Haroutunian V, Zhu J, Donovan MJ, Sharp AJ, Casaccia P. Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains. Nat Neurosci. 2013 Nov 24. doi: 10.1038/nn.3588. [Epub ahead of print] Using the Illumina 450K array and a stringent statistical analysis with age and gender correction, we report genome-wide...

PERKing up myelin repair

Lin Y, Huang G, Jamison S, Li J, Harding HP, Ron D, Lin W. PERK Activation Preserves the Viability and Function of Remyelinating Oligodendrocytes in Immune-Mediated Demyelinating Diseases.Am J Pathol. 2013 Nov doi:pii: S0002-9440(13)00721-9. 10.1016/j.ajpath.2013.10.009. [Epub ahead of print] Remyelination occurs in multiple sclerosis (MS) lesions but is generally considered to be insufficient...

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