ArchiveNovember 2013

Blog Advent Calendar

Well it is that time of the year again and it is time for the  House of Mouse Advent calendar.   Back by Popular demand! I will be donning new outfits for the latest offering, so I have to thank my Designer Anna (& Previously Naomi) for making such wonderful clothes. In 2011 (for research Day 2012) there was a Christmas Theme and in 2012 (for Research Day 2013) we got to meet TeamG...

Beta-interferon in CIS 8-year follow-up

Early treatment delays cognitive progression. #MSBlog #MSResearch “What do long-term extension studies tell us? They give us insights that are not necessarily obvious in the short 2-year pivotal trial. The one that stands out in this 8-year open-label extension study is that CISers treated immediately with IFNbeta had better cognitive outcomes at 8 years compared to MSers who had a delayed...

Survey results: MSology and eMedicine Portal

MSology survey results. There is support for a MS eMedicine portal. #MSBlog #MSResearch “The results of this survey are self-explanatory. It is clear that most MSers who read this blog have access to healthcare professionals who specialise in MS. Things are clearly improving. I am reassured to hear that there is support for a eMedicine MS-specific portal, which I plan to set-up in the...

CCSVI November

MSResearch#; #CCSVI Trials maybe doomed to fail Kazibudzki M, Latacz P, Ludyga T, Simka M. Efficacy and safety of cutting balloons for the treatment of obstructive lesions in the internal jugular veins. J Cardiovasc Surg (Torino). 2013 Oct 24. [Epub ahead of print] Aim: In this technical note we present the results of endovascular treatment for chronic cerebrospinal venous insufficiency with the...

ShiftMS: Peoples Hot Topic – Repurposing of Drugs

Can we repurpose drugs? #MSBlog #MSResearch Our annual MS Research Day is facing delays; will a series of Google hangouts be an appropriate substitute? #MSResearch #MSBlog “Finally my first hangout in collaboration with ShiftMS. We are planning to do these more often in the New Year. You may be aware that the scheduling of the 2014 UCLP MS Research Day will be delayed and...

21st European Charcot Meeting, Baveno, Italy

What a fight? MRI vs. clinical outcomes. Who won? #MSBlog #MSResearch “The following is my presentation from this morning at the European Charcot Meeting in Baveno, Italy. I covered laboratory measures of disease variability and prognosis. My talk was benign compared to the sparring bout, or some would argue fist-fight, between George Ebers and the MRI lobby. It made for entertaining...

Animal testing to get even more expensive?

Nathoo N, Yong VW, Dunn JF. Using magnetic resonance imaging in animal models to guide drug development in multiple sclerosis.Mult Scler. 2013 Nov 21. [Epub ahead of print] Major advances are taking place in the development of therapeutics for multiple sclerosis (MS), with a move past traditional immunomodulatory/immunosuppressive therapies toward medications aimed at promoting remyelination or...

Don’t Forget Digesting Science

Our American readers will have been just digested their Thanksgiving Turkey, so don’t to forget to Digest some Science.                                    www.digestingscience.co.uk                             A site for...

Blocking LINGO1 in fish promotes myelination

Yin W, Hu B Knockdown of Lingo1b protein promotes myelination and oligodendrocyte differentiation in zebrafish. Exp Neurol. 2013 Nov. doi:pii: S0014-4886(13)00336-1.10.1016/j.expneurol.2013.11.012. [Epub ahead of print] Demyelinating diseases include multiple sclerosis, which is a neurodegenerative disease characterized by immune attacks on the central nervous system (CNS), resulting in myelin...

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