Archive2013

Modelling retroviral involvement in MS

Perron H, Dougier-Reynaud HL, Lomparski C, Popa I, Firouzi R, Bertrand JB, Marusic S, Portoukalian J, Jouvin-Marche E, Villiers CL, Touraine JL, Marche PN. Human endogenous retrovirus protein activates innate immunity and promotes experimental allergic encephalomyelitis in mice. PLoS One. 2013 Dec 6;8(12):e80128. doi: 10.1371/journal.pone.0080128. Multiple sclerosis (MS) is a complex...

Progression slower than expected

Pandey KS et al. Clinical course in multiple sclerosis patients presenting with a history of progressive disease Mult scler Rel Dis 2013 2:67-71 Objectives: Determine the likelihood of worsening clinical status in the near-term course of progressive MS and evaluate the predictive validity of our diagnostic impression of progressive forms of MS.Methods:Retrospective review of charts from 175...

Nerve Damage can promote Repair

Fressinaud C, Eyer J. Neurofilament-tubulin binding site peptide NFL-TBS.40-63 increases the differentiation of oligodendrocytes in vitro and partially prevents them from lysophosphatidyl choline toxiciy. J Neurosci Res. 2014;92(2):243-53. doi: 10.1002/jnr.23308.  During multiple sclerosis (MS), the main axon cystoskeleton proteins, neurofilaments (NF), are altered, and their release into...

Peripheral nerve involvement in MS

Warabi Y, Yamazaki M, Shimizu T, Nagao M. Abnormal nerve conduction study findings indicating the existence of peripheral neuropathy in multiple sclerosis and neuromyelitis optica. Biomed Res Int. 2013;2013:847670. Objective. Chronic inflammatory demyelinating polyneuropathy (CIDP) has been reported in patients with multiple sclerosis (MS). However, there have been limited reports of...

Smoking and Drinking

Weiland TJ, Hadgkiss EJ, Jelinek GA, Pereira NG, Marck CH, van der Meer DM. The association of alcohol consumption and smoking with quality of life, disability and disease activity in an international sample of people with multiple sclerosis. J Neurol Sci. 2013 . doi:pii: S0022-510X(13)03008-6. 10.1016/j.jns.2013.10.046. [Epub ahead of print] BACKGROUND:Modifiable lifestyle factors represent...

MS having a laugh

Ferner RE, Aronson JK. Laughter and MIRTH (Methodical Investigation of Risibility, Therapeutic and Harmful): narrative synthesis.BMJ. 2013;347:f7274. doi: 10.1136/bmj.f7274. OBJECTIVE:To review the beneficial and harmful effects of laughter.DATA SOURCES AND REVIEW METHODS:We searched Medline (1946 to June 2013) and Embase (1974 to June 2013) for reports of benefits or harms from laughter in...

Synaptic plasticity and PDGF signalling control Progression

Mori F, Rossi S, Piccinin S, Motta C, Mango D, Kusayanagi H, Bergami A, Studer V, Nicoletti CG, Buttari F, Barbieri F, Mercuri NB, Martino G, Furlan R, Nisticò R, Centonze D. Synaptic Plasticity and PDGF Signaling Defects Underlie Clinical Progression in Multiple Sclerosis.J Neurosci. 2013 Dec 4;33(49):19112-9. doi: 10.1523/JNEUROSCI.2536-13.2013. Neuroplasticity is essential to prevent clinical...

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