Archive2014

Blocking white blood cell trafficking into the brain

Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SM, Hirst MC, de Vries HE, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA. Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. J Cereb Blood Flow Metab. 2014 Dec 17. doi: 10.1038/jcbfm.2014.207. [Epub ahead of print] Pro-inflammatory...

Connecting the cerebllum

Romascano D, Meskaldji DE, Bonnier G, Simioni S, Rotzinger D, Lin YC, Menegaz G, Roche A, Schluep M, Pasquier RD, Richiardi J, Van De Ville D, Daducci A, Sumpf T, Fraham J, Thiran JP, Krueger G, Granziera C. Multicontrast connectometry: A new tool to assess cerebellum alterations in early relapsing-remitting multiple sclerosis. Hum Brain Mapp. 2014. doi: 10.1002/hbm.22698. [Epub ahead of print]...

Statistics

One comment today has asked if we look at the use of  soap and whether this correlates with MS. I guess the list of possibilities are endless, and if you do enough analysis you will find associations (for some weird ones click here) We have to be careful how we use statistics “He uses statistics as a drunken man uses lamp-posts… for support rather than illumination.”...

EBV and fatness increase the risk ofMS

Hedström AK, Lima Bomfim I, Hillert J, Olsson T, Alfredsson L.Obesity interacts with infectious mononucleosis in risk of multiple sclerosis. Eur J Neurol. 2014 Dec 20. doi: 10.1111/ene.12620. [Epub ahead of print]BACKGROUND AND PURPOSE:The possible interaction between adolescent obesity and past infectious mononucleosis (IM) was investigated with regard to multiple sclerosis (MS) risk...

Debbie Purdy: Right-to-die campaigner dies

Debbie Purdy (c. 1963 – 23 December 2014) was a British political activist from Bradford, West Yorkshire, with primary progressive MS, notable for her challenge to the law in England and Wales as relates to assisted suicide.  Debbie wanted choice and control over her death should she consider her suffering unbearable. She was seeking peace of mind that her wishes would be respected, but also...

Autoimmunity and MS

Marrie RA, Reider N, Cohen J, Stuve O, Sorensen PS, Cutter G, Reingold SC, Trojano M. A systematic review of the incidence and prevalence of autoimmune disease in multiple sclerosis.Mult Scler. 2014 Dec . pii: 1352458514564490. [Epub ahead of print] BACKGROUND:As new therapies emerge which increase the risk of autoimmune disease it is increasingly important to understand the incidence of...

Cannabinoids as neuroprotectants

#MSreseach. Treatment of progressive MS. Lost opportunity Gareth Pryce, Dieter R. Riddall, David L. Selwood, Gavin Giovannoni, David BakerNeuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids. Journal of Neuroimmune PharmacologyDecember 2014 Multiple sclerosis (MS) is the major immune-mediated, demyelinating...

Tai Chi for Balance

Azimzadeh E, Hosseini MA, Nourozi K, Davidson PM. Effect of Tai Chi Chuan on balance in women with multiple sclerosis. Complement Ther Clin Pract. 2014 . pii: S1744-3881(14)00063-2. doi: 10.1016/j.ctcp.2014.09.002. [Epub ahead of print] OBJECTIVE:To examine the effect of Tai Chi Chuan on balance in women with multiple sclerosis in Iran.DESIGN: 36 women with multiple sclerosis who...

Botox for bladder is cost effective

Hamid R, Loveman C, Millen J, Globe D, Corbell C, Colayco D, Stanisic S, Gultyaev D.Cost-Effectiveness Analysis of OnabotulinumtoxinA (BOTOX) for the Management of Urinary Incontinence in Adults with Neurogenic Detrusor Overactivity: A UK Perspective. Pharmacoeconomics. 2014. [Epub ahead of print] OBJECTIVES:To evaluate the cost effectiveness of BOTOX, 200 units [200 U]) for the management...

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