Archive2014

Interim trial results: Bone Marrow Stem Cell Replacement Therapy

Is  hematopoietic stem cell transplant a realistic treatment for MS? #MSBlog #MSResearch “We are aware that a lot of readers of this blog are proponents of more aggressive therapy. The abstract below is the interim, or 3-year, results of the international autologous hematopoietic stem cell transplant (HCT) trial. The results are very encouraging. Please note that this is...

Blocking white blood cell trafficking into the brain

Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SM, Hirst MC, de Vries HE, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA. Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. J Cereb Blood Flow Metab. 2014 Dec 17. doi: 10.1038/jcbfm.2014.207. [Epub ahead of print] Pro-inflammatory...

Connecting the cerebllum

Romascano D, Meskaldji DE, Bonnier G, Simioni S, Rotzinger D, Lin YC, Menegaz G, Roche A, Schluep M, Pasquier RD, Richiardi J, Van De Ville D, Daducci A, Sumpf T, Fraham J, Thiran JP, Krueger G, Granziera C. Multicontrast connectometry: A new tool to assess cerebellum alterations in early relapsing-remitting multiple sclerosis. Hum Brain Mapp. 2014. doi: 10.1002/hbm.22698. [Epub ahead of print]...

Statistics

One comment today has asked if we look at the use of  soap and whether this correlates with MS. I guess the list of possibilities are endless, and if you do enough analysis you will find associations (for some weird ones click here) We have to be careful how we use statistics “He uses statistics as a drunken man uses lamp-posts… for support rather than illumination.”...

ClinicSpeak: the legacy of Debbie Purdy

Imagine being diagnosed with MS and your only reference to the disease is someone in a wheelchair seeking assisted suicide? #ClinicSpeak “In the UK Debbie Purdy is a household name; she became a MS celebrity for her campaign to decriminalise assisted suicide. Her status in UK society is cemented by the fact that her premature death has been covered by the BBC, Sky News and ITV TV news...

EBV and fatness increase the risk ofMS

Hedström AK, Lima Bomfim I, Hillert J, Olsson T, Alfredsson L.Obesity interacts with infectious mononucleosis in risk of multiple sclerosis. Eur J Neurol. 2014 Dec 20. doi: 10.1111/ene.12620. [Epub ahead of print]BACKGROUND AND PURPOSE:The possible interaction between adolescent obesity and past infectious mononucleosis (IM) was investigated with regard to multiple sclerosis (MS) risk...

ClinicSpeak: suicidal ideation and suicide in MS

This is a reposting from the 23 March 2014. How should I address the problem of suicide in MS? #ClinicSpeak #MSBlog #MSResearch “We know that MSers are at increased risk of suicide; various studies put this risk at between 2 and 7 times the background risk. The study below studies suicidal ideation in MSers and found that at baseline 8% of MSers had suicidal ideation with an increase to 22%...

Debbie Purdy: Right-to-die campaigner dies

Debbie Purdy (c. 1963 – 23 December 2014) was a British political activist from Bradford, West Yorkshire, with primary progressive MS, notable for her challenge to the law in England and Wales as relates to assisted suicide.  Debbie wanted choice and control over her death should she consider her suffering unbearable. She was seeking peace of mind that her wishes would be respected, but also...

Cannabinoids as neuroprotectants

#MSreseach. Treatment of progressive MS. Lost opportunity Gareth Pryce, Dieter R. Riddall, David L. Selwood, Gavin Giovannoni, David BakerNeuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids. Journal of Neuroimmune PharmacologyDecember 2014 Multiple sclerosis (MS) is the major immune-mediated, demyelinating...

Autoimmunity and MS

Marrie RA, Reider N, Cohen J, Stuve O, Sorensen PS, Cutter G, Reingold SC, Trojano M. A systematic review of the incidence and prevalence of autoimmune disease in multiple sclerosis.Mult Scler. 2014 Dec . pii: 1352458514564490. [Epub ahead of print] BACKGROUND:As new therapies emerge which increase the risk of autoimmune disease it is increasingly important to understand the incidence of...

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