ArchiveJanuary 2014

Lower Cancer Risk in MS

Catalá-López F, Suárez-Pinilla M, Suárez-Pinilla P, Valderas JM, Gómez-Beneyto M, Martinez S, Balanzá-Martínez V, Climent J, Valencia A, McGrath J, Crespo-Facorro B, Sanchez-Moreno J, Vieta E, Tabarés-Seisdedos R. Inverse and Direct Cancer Comorbidity in People with Central Nervous System Disorders: A Meta-Analysis of Cancer Incidence in 577,013 Participants of 50 Observational Studies...

Hope buffering the Impact of MS

The Stress-Buffering Effects of Hope on Adjustment to Multiple Sclerosis.Madan S, Pakenham KI.Int J Behav Med. 2014 Jan 17. [Epub ahead of print]BACKGROUND:Hope is an important resource for coping with chronic illness; however, the role of hope in adjusting to multiple sclerosis (MS) has been neglected, and the mechanisms by which hope exerts beneficial impacts are not well understood...

Cognition problems associated with changes in nerve signalling molecules

Muhlert N, Atzori M, De Vita E, Thomas DL, Samson RS, Wheeler-Kingshott CA, Geurts JJ, Miller DH, Thompson AJ, Ciccarelli O. Memory in multiple sclerosis is linked to glutamate concentration in grey matter regions. J Neurol Neurosurg Psychiatry. 2014 Jan 15 OBJECTIVE: Glutamate is the principal excitatory neurotransmitter and is involved in normal brain function. Cognitive...

Are infections driving T cells to speed progression

Zastepa E, Fitz-Gerald L, Hallett M, Antel J, Bar-Or A, Baranzini S, Lapierre Y, Haegert DG.Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS.Neurology. 2014 Jan. [Epub ahead of print] OBJECTIVE: Our objective was to determine whether altered naive CD4 T-cell biology contributes to development of disease progression in secondary progressive multiple...

MS in the Media.

#MSResearch. #TheMirror and #Miriam Stoppard gives current MSinformation..Not  Yesterday MS was in the Rags and wonder what news they had to say.  Doctor Mirianm Stoppard = celebrity Pop- Doc posted in the Daily Mirror (A British Newspaper) This story talks about the work presented in Nature by Top Boffins in Cambridge who have found 50 genes..well 57 to be precise and Simon...

How does NICE measure value for money?

#MS Research how does NIce measure value for money How NICE measures value for money in relation to public health interventions Is the National Institute of Clinical Excellence really NICE and an look after the financial purse. Yesterday ProfG was attacked for his views about what is included and what is not. Cost–utility analysis considers people’s quality of life and the length of life...

ACE inhibitors are not so ACE

Doerner M, Beckmann K, Knappertz V, Kappos L, Hartung HP, Filippi M, O’Connor PW, Arnason B, Cook S, Jeffery D, Comi G, Limmroth V Effects of Inhibitors of the Renin-Angiotensin System on the Efficacy of Interferon beta-1b: A post hoc Analysis of the BEYOND Study. Eur Neurol. 2014 Jan;71(3-4):173-179. [Epub ahead of print] Background: In experimental autoimmune encephalomyelitis, inhibition...

Lack of blinding in Trials gives bias

Hróbjartsson A, Thomsen AS, Emanuelsson F, Tendal B, Rasmussen JV, Hilden J, Boutron I, Ravaud P, Brorson S. Observer bias in randomized clinical trials with time-to-event outcomes: systematic review of trials with both blinded and non-blinded outcome assessors. Int J Epidemiol. 2014 Jan. [Epub ahead of print] BACKGROUND:We wanted to evaluate the impact of nonblinded outcome assessors on...

Target for MS found in Young People with Demyelination

Kraus et al. Potassium channel KIR4.1-specific antibodies in children with acquired demyelinating CNS disease.Neurology. 2014 Jan.  OBJECTIVE: A serum antibody against the inward rectifying potassium channel KIR4.1 (KIR4.1-IgG) was recently discovered, which is found in almost half of adult patients with multiple sclerosis. We investigated the prevalence of KIR4.1-IgG in children with...

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