Target for MS found in Young People with Demyelination

Kraus et al. Potassium channel KIR4.1-specific antibodies in children with acquired demyelinating CNS disease.Neurology. 2014 Jan. 

OBJECTIVE: A serum antibody against the inward rectifying potassium channel KIR4.1 (KIR4.1-IgG) was recently discovered, which is found in almost half of adult patients with multiple sclerosis. We investigated the prevalence of KIR4.1-IgG in children with acquired demyelinating disease (ADD) of the CNS. We also compared antibody responses to KIR4.1 and myelin oligodendrocyte glycoproteins (MOGs), another potential autoantigen in childhood ADDs.

METHODS: We measured KIR4.1-IgG by ELISA in children with ADD (n = 47), other neurologic disease (n = 22), and autoimmune disease (n = 22), and in healthy controls (HCs) (n = 18). One hundred six samples were also measured by capture ELISA. Binding of KIR4.1-IgG human subcortical white matter was analyzed by immunofluorescence. Anti-MOG antibodies were measured using a cell-based assay.

RESULTS: KIR4.1-IgG titers were significantly higher in children with ADD compared with all control groups by ELISA and capture ELISA (p < 0.0001, p < 0.0001). Overall, 27 of 47 patients with ADD (57.45%) but none of the 62 with other neurologic disease or autoimmune disease or the HCs (0%) were KIR4.1-IgG antibody positive by ELISA. Sera containing KIR4.1-IgG stained glial cells in brain tissue sections. No correlation among KIR4.1-IgG, age, or MOG-IgG was observed in the ADD group.

CONCLUSION: Serum antibodies to KIR4.1 are found in the majority of children with ADD but not in children with other diseases or in HCs. These findings suggest that KIR4.1 is an important target of autoantibodies in childhood ADD.

This is a follow up to the original study by Srivastava R et al. , Potassium channel KIR4.1 as an immune target in multiple sclerosis. N Engl J Med. 2012;367.115. 

So if you think it is a risk factor in MS you would how to see this as a early feature. In this study they looked a child hood demyelinating disease. 

We are still waiting for confirmatory studies to surface,there has been a study questioning the validty of that

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  • I may be wrong but one of the chief profs involved (Hemmer) did a presentation on this last year in Germany and it said that he (sadly) could not replicate his finding.

    I may have confused the finding though and you're waiting for the Yale peeps?

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