ArchiveFebruary 2014

Clinic Speak: switching from natalizumab to fingolimod

Rebound post-natalizumab can be prevented or reduced by early switch to fingolimod. #MSBlog #MSResearch #ClinicSpeak “The study below confirms the results of the TOFINGO study, MSBase and several smaller studies, which show that if you have a wash-out period when switching from natalizumab you are  more likely to have a relapse  than if you don’t have a washout. Why...

INSPIRE STUDY RECRUITMENT UPDATE

INSPIRE Study update: we are almost there; 19 study subjects recruited and 5 to go. #MSBlog #MSResearch “In response to several requests, the following is a recruitment update on the INSPIRE Study.” A Phase II Baseline Versus Treatment Study to Determine the Efficacy of Raltegravir (Isentress) in Preventing Progression of Relapsing Remitting Multiple Sclerosis as Determined by...

Clinic Speak: why do you use complementary or alternative medicines?

Do you use complementary or alternative medicines? Why? #ClinicSpeak #MSBlog #MSResearch “What is complementary or alternative medicine (CAM)? CAM is any practice that is put forward as having the healing effects of medicine but is not based on evidence gathered using the scientific method. CAM consists of a wide range of health care practices, products and therapies, using alternative...

Remyelination of cortical lesions may not always repair

Rodriguez EG, Wegner C, Kreutzfeldt M, Neid K, Thal DR, Jürgens T, Brück W, Stadelmann C, Merkler D. Oligodendroglia in cortical multiple sclerosis lesions decrease with disease progression, but regenerate after repeated experimental demyelination. Acta Neuropathol. 2014 Feb 25. [Epub ahead of print] Cerebral cortex shows a high endogenous propensity for remyelination. Yet, widespread subpial...

Troll-Free Zone.

Although we appear to be a Troll-Free Zone, we still get the odd person spilling some bile. Their posts however end up in spam or go straight to the bin. This online report about Internet trolling shows that they (trolls) show narcissism (egocentrism and preoccupation with prestige), machiavellianism (tendency to deceive and manipulate), psychopathy (lack of empathy and inhibition), and sadism...

Survey results: bone marrow transplantation

Are MSers really this willing to take risks? #MSBlog #MSResearch “In response to my posts on bone marrow transplantation (BMT) and brain atrophy after BMT in MSers I have the following interim results of our one question survey. Could  this really be correct? Almost 50% of MSers are prepared to take the risks of BMT. Only 32% said no. If these result are correct I...

ClinicSpeak: body temperature and fatigue

Will lowering your body temperature help your fatigue? #ClinicSpeak #MSBlog #MSResearch “The study below is very interesting. Its findings are in line with some of my own anecdotal observations in MSers and has potentially major implications for all MSers. In short RRMSers have a higher body temperature than controls and this is associated with worse fatigue.” “Why would...

MS is increasing in New Zealand

Alla S, Pearson J, Debernard L, Miller D, Mason D. The Increasing Prevalence of Multiple Sclerosis in New Zealand. Neuroepidemiology. 2014 Feb;42(3):154-160. [Epub ahead of print] Background: New Zealand (NZ) has a high prevalence of multiple sclerosis (MS). Worldwide, the prevalence of MS appears to be increasing.  Objectives: To review all published prevalence studies undertaken...

More on BMT, neurotoxicity and brain atrophy

BMT accelerates brain atrophy rates and disability progression in SPMS. #MSBlog #MSResearch “My post on bone marrow transplantation (BMT) yesterday generated some discussion about brain atrophy. The BMT procedure requires chemotherapy to ablate or wipe-out your immune system to allow stem cell transplantation. The chemotherapy drugs that are used are neurotoxic, i.e. they damage the brain...

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