ArchiveApril 2014

Kir 4.1 may be lost in MS lesions

Schirmer L, Srivastava R, Kalluri SR, Böttinger S, Herwerth M, Carassiti D, Srivastava B, Gempt J, Schlegel J, Kuhlmann T, Korn T, Reynolds R, Hemmer B. Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions. Ann Neurol. 2014 Apr 29. doi: 10.1002/ana.24168. [Epub ahead of print] Objective: Serum antibodies against the glial potassium channel KIR4.1 are found in a subpopulation...

Unable to Repeat the Autoimmune target in MS

Nerrant E, Salsac C, Charif M, Ayrignac X, Carra-Dalliere C, Castelnovo G, Goulabchand R, Tisseyre J, Raoul C, Eliaou JF, Labauge P, Vincent T. Lack of confirmation of anti-inward rectifying potassium channel 4.1 antibodies as reliable markers of multiple sclerosis. Mult Scler. 2014 Apr  [Epub ahead of print] BACKGROUND. Auto-antibodies against the potassium channel inward...

NHS Privatisation and brain child of New labour?

Tony Blair British Prime Minister for 1997-2007 has been attributed to many things in Wikipedia the Good Friday Agreement, Freedom of Information Act, but few see him as a potential slayer of the British University System with the enforced growth of student numbers leading to unsustainable boom and now bust. Many graduates are left unemployed, with devalued A levels and degrees and crippling debt...

CXCR7 another target for remyelination

Williams JL, Patel JR, Daniels BP, Klein RS. Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system. J Exp Med. 2014 Apr. [Epub ahead of print] Current treatment modalities for the neurodegenerative disease multiple sclerosis (MS) use disease-modifying immunosuppressive compounds but do not promote repair. Although several potential...

Novartis Launch Symtrac an ap to monitor your progress

Having problems remembering what is going on, Novartis UK has just launched a new iphone Ap apparently Android Ap to Follow Soon for the 4Rs of Relapse (Recognise, Record, Report, Review)                        SymTrac™ is a free iPhone app that apparently helps people with MS track general well being and symptoms over time. The data...

MS Life 2014 Videos

For those of You not at MS life 2014 the sessions were filmed and are on YouTube so you can search on MS Life 2014 see what every one said. I will post the science ones  in the next few days when I have some time.

If you want to hear ProfG here is the link

Questions to Ask Your Neurologist-MS life

Part of this is a repost from ProfG and follows on from meet and greet at MS Life 2014. One thing that is clear we need to support all aspects of  Education, Education, and Education  MS Society has, is and needs to be as proactive in this as possible, otherwise the Postcode lottery will remain. The “Meet the Scientist” session at MS life 2014 was a positive and busy time...

Combination of two anti-inflammatories can save nerves

Reick C, Ellrichmann G, Thöne J, Scannevin RH, Saft C, Linker RA, Gold R Neuroprotective dimethyl fumarate synergizes with immunomodulatory interferon beta to provide enhanced axon protection in autoimmune neuroinflammation. Exp Neurol. 2014 Apr pii: S0014-4886(14)00098-3. Despite recent advances in development of treatments for multiple sclerosis, there is still an unmet need for more effective...

RRMS- Placebo Controlled Trials are they Ethical

There are currently over 9 different licensed therapies for the treatment of relapsing-remitting multiple sclerosis. In the Year 2014 is it really ethical to undertake placebo-controlled trials for a number of years in relapsing-remitting MS? Why, because we should know that a substantial number of people will develop relapse and accumulate damage and possible deficit as a result? How...

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