“The study below from Spain confirms what we know already; MS reduces your life expectancy by approximately 8 years and most deaths in MSers are related to MS complications. Are you surprised? Would you be persuaded to take a DMT that increased your survival? At the commissioning meeting I attended earlier this week several commissioners were impressed by the 21-year survival data showing that starting interferon-beta-1b 3-and-a-half years early increased your chances of being alive at 21 years by ~50%. The question is what will the effect be with more effective DMTs that clearly have a greater impact on switching off the shredder and saving brain?”
Epub: Rodríguez-Antigüedad et al. Mortality and Cause of Death in Multiple Sclerosis: Findings from a Prospective Population-Based Cohort in Bizkaia, Basque Country, Spain. Neuroepidemiology. 2014;42:219-225.
Background: Mortality studies of MSers are scarce.
Objective: To assess mortality of MSers included in a large MS cohort from the county of Bizkaia in Spain.
Methods: MSers were collected from a dynamic population-based cohort of patients with MS from the county of Bizkaia (named the ‘Bizkaia cohort’) in the Basque Country (Spain). Data from official registries were used for estimating mortality indicators.
Results: During a 24-year period (1987-2011), a total of 1,283 MSers were included in the Bizkaia cohort. Eighty-nine MSers 6.9%) had died before December 31, 2011. The standardized mortality ratio was 2.78 for the whole group (3.26 for men and 2.73 for women), with a decreased life expectancy of 6.53 years. The mean survival from the onset of MS in deceased MSers was 22.4 years. Death was related directly or indirectly to MS in 57 MSers and unrelated in 27, while the cause of death was unknown in the remaining 5. Respiratory infection and sepsis were the most frequent MS-related causes of death. Differences in survival according to gender or disease course were not observed.
Conclusion: MSers included in the ‘Bizkaia cohort’ had an almost threefold increase in the risk for death. Life expectancy is reduced by 6-10 years.