ArchiveJune 2014

Give us more money to throw down the toilet?

Malfitano AM, Marasco G, Proto MC, Laezza C, Gazzerro P, Bifulco M. Statins in neurological disorders: an overview and update.Pharmacol Res. 2014 Jun 19. pii: S1043-6618(14)00099-1. doi: 10.1016/j.phrs.2014.06.007. [Epub ahead of print] Statins have, at present, the potential to provide a new therapeutic target for various neurological diseases. It is well established that statins reduce...

Spinal cord loss associated with disability

Lukas C, Knol DL, Sombekke MH, Bellenberg B, Hahn HK, Popescu V, Weier K, Radue EW, Gass A, Kappos L, Naegelin Y, Uitdehaag BM, Geurts JJ, Barkhof F, Vrenken H. Cervical spinal cord volume loss is related to clinical disability progression in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2014 Jun . pii: jnnp-2014-308021. doi: 1 OBJECTIVE: To examine the temporal evolution of spinal...

Multiple Sclerosis Management 2014, Vienna: Social Media and MS

How do you feel about your neurologists engaging with you using social media? #MSBlog #MSResearch “I was meant to attend the ‘Multiple Sclerosis Management 2014: Raising expectations’ meeting in Vienna yesterday, but had to pull out because of domestic commitments. I managed to give my talk using a webinar format at it seemed to go well, but it is difficult to know how well when...

The real life effect of Sativex

Flachenecker P, Henze T, Zettl UK. Long-Term Effectiveness and Safety of Nabiximols (Tetrahydrocannabinol/Cannabidiol Oromucosal Spray) in Clinical Practice. Eur Neurol. 2014 Jun 18;72(1-2):95-102. [Epub ahead of print] Background: Nabiximols (Sativex®), in a cannabinoid-based oromucosal spray, is an add-on therapy option for patients with moderate to severemultiple sclerosis spasticity...

Review of female sexual problems

Epub: Cordeau D, Courtois F. Sexual disorders in women with MS: Assessment and management.Ann Phys Rehabil Med. 2014 Jun 5. pii: S1877-0657(14)01727-8. doi: 10.1016/j.rehab.2014.05.008.  OBJECTIVES:Summarize the data on sexual disorders in women with multiple sclerosis (MS). METHOD:Review of 99 Pubmed articles covering sexual dysfunction in women with MS. RESULTS:Prevalence of...

CCSVI June

Epub: Costello et al. Validity of the diagnostic criteria for chronic cerebrospinal venous insufficiency and association withmultiple scleros. CMAJ. 2014 Jun 2. pii: cmaj.131431. BACKGROUND: The chronic cerebrospinal venous insufficiency theory proposes that altered cerebral venous hemodynamics play a role in the pathophysiology of multiple sclerosis. We aimed to explore the validity of this...

Do DMTs delay the onset of secondary progressive MS?

How do we define secondary progressive MS? Is it a rational therapeutic target? #MSBlog #MSResearch “An interesting debate has started within the UK MSology community. Do DMTs that have been shown to reduce relapses, relapse associated disability progression, MRI inflammatory activity (focal lesions), MRI associated damage (T1 blackholes and brain volume loss) delay the onset of SPMS? Some...

First line drugs and Genes not much NEDA

Sellebjerg F, Søndergaard HB, Koch-Henriksen N, Sørensen PS, Oturai AB.Prediction of response to interferon therapy in multiple sclerosis. Acta Neurol Scand. 2014 Jun 18. doi: 10.1111/ane.12269. [Epub ahead of print] OBJECTIVE:Single nucleotide polymorphisms (SNPs) in the genes encoding interferon response factor (IRF)-5, IRF-8 and glypican-5 (GPC5) have been associated with disease activity...

Co-morbidities and MS

MSers are more likely to have multiple diagnoses. #MSBlog #MSResearch “The study below using data from the Scottish Primary Care dataset shows that MSers are much more likely to have one or more comorbidities, or other diseases. The problem with this study is that it implies these other disease are independent of MS, when they are clearly not and a large number of them are...

Progressive MS Alliance

Dealing with Progression in MS is top of the agenda and has been some years but this has become focussed with the action of the Progressive MS Alliance (CLICK HERE) Current members are:  Associazione Italiana Sclerosi Multipla (Italy)  Esclerosis Múltiple España (Spain)  MS Society (UK)  Multiple Sclerosis International Federation  Multiple Sclerosis Society of...

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