ArchiveJune 2014

Give us more money to throw down the toilet?

Malfitano AM, Marasco G, Proto MC, Laezza C, Gazzerro P, Bifulco M. Statins in neurological disorders: an overview and update.Pharmacol Res. 2014 Jun 19. pii: S1043-6618(14)00099-1. doi: 10.1016/j.phrs.2014.06.007. [Epub ahead of print] Statins have, at present, the potential to provide a new therapeutic target for various neurological diseases. It is well established that statins reduce...

Spinal cord loss associated with disability

Lukas C, Knol DL, Sombekke MH, Bellenberg B, Hahn HK, Popescu V, Weier K, Radue EW, Gass A, Kappos L, Naegelin Y, Uitdehaag BM, Geurts JJ, Barkhof F, Vrenken H. Cervical spinal cord volume loss is related to clinical disability progression in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2014 Jun . pii: jnnp-2014-308021. doi: 1 OBJECTIVE: To examine the temporal evolution of spinal...

The real life effect of Sativex

Flachenecker P, Henze T, Zettl UK. Long-Term Effectiveness and Safety of Nabiximols (Tetrahydrocannabinol/Cannabidiol Oromucosal Spray) in Clinical Practice. Eur Neurol. 2014 Jun 18;72(1-2):95-102. [Epub ahead of print] Background: Nabiximols (Sativex®), in a cannabinoid-based oromucosal spray, is an add-on therapy option for patients with moderate to severemultiple sclerosis spasticity...

CCSVI June

Epub: Costello et al. Validity of the diagnostic criteria for chronic cerebrospinal venous insufficiency and association withmultiple scleros. CMAJ. 2014 Jun 2. pii: cmaj.131431. BACKGROUND: The chronic cerebrospinal venous insufficiency theory proposes that altered cerebral venous hemodynamics play a role in the pathophysiology of multiple sclerosis. We aimed to explore the validity of this...

Review of female sexual problems

Epub: Cordeau D, Courtois F. Sexual disorders in women with MS: Assessment and management.Ann Phys Rehabil Med. 2014 Jun 5. pii: S1877-0657(14)01727-8. doi: 10.1016/j.rehab.2014.05.008.  OBJECTIVES:Summarize the data on sexual disorders in women with multiple sclerosis (MS). METHOD:Review of 99 Pubmed articles covering sexual dysfunction in women with MS. RESULTS:Prevalence of...

First line drugs and Genes not much NEDA

Sellebjerg F, Søndergaard HB, Koch-Henriksen N, Sørensen PS, Oturai AB.Prediction of response to interferon therapy in multiple sclerosis. Acta Neurol Scand. 2014 Jun 18. doi: 10.1111/ane.12269. [Epub ahead of print] OBJECTIVE:Single nucleotide polymorphisms (SNPs) in the genes encoding interferon response factor (IRF)-5, IRF-8 and glypican-5 (GPC5) have been associated with disease activity...

Progressive MS Alliance

Dealing with Progression in MS is top of the agenda and has been some years but this has become focussed with the action of the Progressive MS Alliance (CLICK HERE) Current members are:  Associazione Italiana Sclerosi Multipla (Italy)  Esclerosis Múltiple España (Spain)  MS Society (UK)  Multiple Sclerosis International Federation  Multiple Sclerosis Society of...

Tysabri can affect immune responses in the brain disappearence of oligoclonal bands

Mancuso R, Franciotta D, Rovaris M, Caputo D, Sala A, Hernis A, Agostini S, Calvo M, Clerici M. Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study. Mult Scler. 2014 Jun  pii: 1352458514538111. [Epub ahead of print] Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands...

Falling is common

Nilsagård Y, Gunn H, Freeman J, Hoang P, Lord S, Mazumder R, Cameron M. Falls in people with MS-an individual data meta-analysis from studies from Australia, Sweden, United Kingdom and the United States. Mult Scler. 2014 Jun 16. pii: 1352458514538884. [Epub ahead of print] BACKGROUND:Falls are common in people with multiple sclerosis (PwMS). Previous studies have generally included small samples...

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