ArchiveJuly 2014

Employment: Norway is tragically the exception

Is Norway’s runaway success in relation to MSer employment linked to their top ranking in the Human Development Index? #MSBlog #MSResearch “Yesterday Mouse Doc discussed the article below that showed the employment rate amongst MSers living in county of Norway was 45% at 19 years. These are by far the best figures I have seen to date. I am hoping they indicate a trend that may be...

Progression is this an easy mountain to CLIMB

Raghavan K, Healy BC, Carruthers RL, Chitnis T. Progression rates and sample size estimates for PPMS based on the CLIMB study population. Mult Scler. 2014 Jul. pii: 1352458514541976. [Epub ahead of print] BACKGROUND: The clinical trial design for primary progressive multiple sclerosis (PPMS) requires understanding of disability progression in modern patient cohorts...

No Oligoclonal bands in your CSF means that you do better

Multiple sclerosis patients lacking oligoclonal bands in the cerebrospinal fluid have less global and regional brain atrophy. Ferreira D, Voevodskaya O, Imrell K, Stawiarz L, Spulber G, Wahlund LO, Hillert J, Westman E, Karrenbauer VD. J Neuroimmunol. 2014. pii: S0165-5728(14)00181-7. doi: 10.1016/j.jneuroim.2014.06.010. [Epub ahead of print] To investigate whether multiple sclerosis (MS)...

Mice work may send you down the wrong path becuase of the mouse you use

Kraev A. Parallel universes of Black Six biology. Biol Direct. 2014 Jul 19;9(1):18 Creation of lethal and synthetic lethal mutations in an experimental organism is a cornerstone of genetic dissection of gene function, and is related to the concept of an essential gene. Common inbred mouse strains carry background mutations, which can act as genetic modifiers, interfering with the assignment of...

PLEG RIDY arrives in Europe

It has been announced that the European Regulators have approved Plegridy for MS. Plegridy is an interferon drug, the same type of treatment as Biogen Idec’s first multiple sclerosis therapy, Avonex. While Avonex typically is injected into the muscle once a week, Plegridy can be taken by injection once every two weeks and administered under the skin with a prefilled auto-injector.  This is a...

Employment in MSers (Norway)

Bøe Lunde HM, Telstad W, Grytten N, Kyte L, Aarseth J, Myhr KM, Bø L. Employment among Patients with Multiple Sclerosis-A Population Study. PLoS One. 2014 ;9(7):e103317. doi: 10.1371/journal.pone.0103317. eCollection 2014.OBJECTIVE:To investigate demographic and clinical factors associated with employment in MS. METHODS: The study included 213 (89.9%) of all MS patients in Sogn and...

MS on the up globally

Melcon MO, Correale J, Melcon CM. Is it time for a new global classification of multiple sclerosis? J Neurol Sci. 2014 Jun 29. pii: S0022-510X(14)00421-3 BACKGROUND: The geographic distribution of multiple sclerosis (MS) is classically divided into three zones based on frequency that were established by Kurtzke in the early 1970s. In recent years, an increasing number of...

Charcot Project: INSPIRE Trial fully recruited

The INSPIRE Study is now fully recruited. #MSBlog #MSResearch “In response to several requests, I can now confirm that recruitment for the INSPIRE Study is now complete. The study will be closed when the last subject completes 6 months, i.e. early January. Hence the results of the study will only be know in April/May. It takes this long to clean the data, lock the database and for our...

Surge in vitamin D deficiency rates

Wouldn’t it be a tragedy if we show in 100 years that repleting the population of vD prevented a large proportion of MS? #MSBlog #MSResearch “For those of you living in the US you may find the following non-MS-related publication of interest. It shows a surge in vitamin D deficiency diagnoses and mirrors that what is happening in the UK. We are in the process of auditing our own MS...

Clearing up debris to help repair

Rajbhandari L, Tegenge MA, Shrestha S, Ganesh Kumar N, Malik A, Mithal A, Hosmane S, Venkatesan A. Toll-like receptor 4 deficiency impairs microglial phagocytosis of degenerating axons.Glia. 2014 Jul 8. doi: 10.1002/glia.22719. [Epub ahead of print] Microglia are rapidly activated in the central nervous system (CNS) in response to a variety of injuries, including inflammation, trauma, and...

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