ArchiveAugust 2014

An alternative test for oligoclonal bands again

Hassan-Smith G, Durant L, Tsentemeidou A, Assi LK, Faint JM, Kalra S, Douglas MR, Curnow SJ.High sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspectedmultiple sclerosis. J Neuroimmunol. 2014. pii: S0165-5728(14)00236-7. doi: 10.1016/j.jneuroim.2014.08.003. [Epub ahead of print] Cerebrospinal fluid (CSF) analysis is routinely used in the diagnostic...

CCSVI August

Leone MA, Raymkulova O, Lochner P, Bolamperti L, Rivadossi G, Stecco A, Zaccala G, Maggio M, Liboni W, Guido M, Coppo L, Imperiale D.Chronic cerebrospinal venous insufficiency is not associated with chronic venous disorders: A case-control study.Phlebology. 2014 Jul 31. pii: 0268355514544782. [Epub ahead of print] OBJECTIVES:To evaluate the relationship between chronic cerebrospinal venous...

Insoles don’t work?

Kalron A, Pasitselsky D, Greenberg-Abrahami M, Achiron A. Do textured insoles effect postural control and spatiotemporal parameters of gait and plantar sensation in people with multiple sclerosis? PM R. 2014 Aug 18. pii: S1934-1482(14)01327-6 BACKGROUND:Balance and gait deficits are common in people with multiple sclerosis (MS). Physical interventions directed at improving balance and walking...

MS register spots depression and anxiety

Jones KH, Jones PA, Middleton RM, Ford DV, Tuite-Dalton K, Lockhart-Jones H, Peng J, Lyons RA, John A, Noble JG. Physical Disability, Anxiety and Depression in People with MS: An Internet-Based Survey via the UK MS Register.PLoS One. 2014 Aug 25;9(8):e104604. INTRODUCTION: People with Multiple Sclerosis are known to have a relatively high prevalence of both anxiety and depression. Studies of...

Can we speed up the drug development process?

This is an Ebola virus and it is interesting that governments have approved the testing of an relatively-untested drug (it has not had the proper human trials) in people infected with this deadly virus…..However, when it comes to progressive MS, you have to wait until it goes through years of testing before you get a choice of whether you take the risk of a test drug in a trial...

Regulatory CD8 positive T cells controlling autoimmunity

Ping Y, Bamford R, Waldmann TA. IL-15-dependent CD8+ CD122+ T cells ameliorate experimental autoimmune encephalomyelitis by modulating IL-17 production by CD4+ T cells. Eur J Immunol. 2014 doi: 10.1002/eji.201444675. [Epub ahead of print] Interleukin-15 (IL-15) is an inflammatory cytokine whose role in autoimmune diseases has not been fully elucidated. Th17 cells have been shown to play critical...

Another guideline – but this time we’re involved!

Guidelines for uniform reporting of body fluid biomarker studies in neurologic disorders. Gnanapavan S, Hegen H, Khalil M, Hemmer B, Franciotta D, Hughes S, Hintzen R, Jeromin A, Havrdova E, Tumani H, Bertolotto A, Comabella M, Frederiksen J, Alvarez-Cermeño JC, Villar L, Galimberti D, Myhr KM, Dujmovic I, Fazekas F, Ionete C, Menge T, Kuhle J, Keir G, Deisenhammer F, Teunissen C, Giovannoni G...

Sleep problems are common

Brass SD, Li CS, Auerbach S.The underdiagnosis of sleep disorders in patients with multiple sclerosis. J Clin Sleep Med. 2014 Sep 15;10(9). pii: jc-00207-12. STUDY OBJECTIVES:To report at a population level the prevalence of restless legs syndrome, insomnia, and the risk of obstructive sleep apnea in multiple sclerosis patients. Sleep patterns and associations with fatigue and daytime...

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