ArchiveSeptember 2014

Stem cell trials are here

Human Placenta-Derived Cells (PDA-001) for the Treatment of Adults With Multiple Sclerosis: A Randomized, Placebo-Controlled, Multiple-Dose Study Fred D. Lublin, James D. Bowen, John Huddlestone, Marcelo Kremenchutzky, Adam Carpenter, John R. Corboy, Mark S. Freedman, Lauren Krupp, Corri Paulo, Robert J. Hariri, Steven A. Fischkoff DOI: Background:Infusion of PDA-001, a preparation of...

Another pro-myelinating factor

 Cruz-Martinez P, Martinez-Ferre A, Jaramillo-Merchán J, Estirado A, Martinez S, Jones J.FGF8 Activates Proliferation and Migration in Mouse Post-Natal Oligodendrocyte Progenitor Cells. PLoS One. 2014 Sep;9(9):e108241. doi: 10.1371/journal.pone.0108241. eCollection 2014 Fibroblast growth factor 8 (FGF8) is a key molecular signal that is necessary for early embryonic development of the...

How much does a Relapse Cost?

K. O׳Connell K et al. Economic costs associated with an MS relapse Mult Scler Rel DisordDOI: 10.1016/j.msard.2014.09.002 Background:Multiple sclerosis (MS) commonly affects young adults and can be associated with significant disability resulting in considerable socioeconomic burden for both patient and society.Aims:The aim was to determine the direct and indirect cost of an MS relapse...

Fampridine making facial pain worse?

Birnbaum G, Iverson J. Dalfampridine may activate latent trigeminal neuralgia in patients with multiple sclerosis. Neurology. 2014 Sep. pii: 10.1212/WNL.0000000000000931. [Epub ahead of print]  OBJECTIVE: To determine the effect of dalfampridine (4-aminopyridine), a broad-spectrum, voltage-dependent potassium channel blocker, on patients with trigeminal nerve dysfunction due to multiple...

IL-17 increases in secondary progressive MS

Huber AK, Wang L, Han P, Zhang X, Ekholm S, Srinivasan A, Irani DN, Segal BM. Dysregulation of the IL-23/IL-17 axis and myeloid factors in secondary progressive MS. Neurology. 2014 . pii: 10.1212/WNL.0000000000000908. [Epub ahead of print] OBJECTIVE:In the current exploratory study, we longitudinally measured immune parameters in the blood of individuals with relapsing-remitting multiple...

RULES OF ENGAGEMENT

One poster asked what are the Rules of Engagement and how to post. What are the do’s and importantly don’ts of posting a comment. Many moons ago you will remember that you could post at will, you would post and it would appear. There could be some heated discussions.  However, invariably posts particularly on CCSVI would attract destructive Trolls…leading to all comments...

Stem cells from an Mser myelinates a mouse.

Douvaras P, Wang J, Zimmer M, Hanchuk S, O’Bara MA, Sadiq S, Sim FJ, Goldman J, Fossati V. Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple SclerosisPatients by Induced Pluripotent Stem Cells. Stem Cell Reports. 2014;3(2):250-259. Multiple sclerosis (MS) is a chronic demyelinating disease of unknown etiology that affects the CNS. While current...

CCSVI saturday

Ploughman M, Harris C, Hogan SH, Murray C, Murdoch M, Austin MW, Stefanelli M. Navigating the “liberation procedure”: a qualitative study of motivating and hesitating factors among people with multiple sclerosis. Patient Prefer Adherence. 2014;8:1205-13 BACKGROUND: The debate within the multiple sclerosis (MS) community initiated by the chronic cerebrospinal venous...

Brain F**k

I was close to the red light district in Amsterdam (at a Post PhD viva dinner-I may add), when I got this email from MD2 about “perhaps the most bizarre post I’ve ever seen”. Whilst I do not usually report on the “cure of the week” about what can stop EAE from developing, this is certainly going to take the biscuit.  We’ve had the inference of resveratol...

Translate

Categories

Recent Posts

Recent Comments

Archives