Is this the Next CCSVI craze you don’t need a neuro to get it…and some unscruplious people could make money from it….So sounds familiar:-)
Pakravan N, Ghaffarinia A, Jalili C, Riazi-Rad F, Tajedini M, Mostafaie A. Seminal vesicle fluid ameliorates experimental autoimmune encephalomyelitis by increasing FoxP3+ regulatory T-cell numbers. Cell Mol Immunol. 2014 Sep. doi: 10.1038/cmi.2014.88. [Epub ahead of print]
Previous studies have shown that insemination elicits the expansion of the natural FoxP3+ regulatory T cell (Treg) pool in female reproductive tissue during mating. Further research demonstrated that this effect was due to seminal vesicle fluid. Indeed, seminal vesicle fluid causes differential recruitment of Tregs into different organs. The recruitment of Tregs into the brain occurs at the lowest rate of all studied organs. In addition, Tregs are present at a lower frequency and/or have a reduced function in multiple sclerosis. These observations prompted us to investigate how intra-CSF administration of seminal vesicle fluid affects experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Our results suggest that seminal vesicle fluid contains all of the ligands required to activate the Treg pool and exhibits an anti-inflammatory effect on organs outside the reproductive system.
If you are going to have a treatment of EAE these days any self-respecting paper usually has a “flavour of the time” as the mechanism of action.
You need enough T regulatory cells to conceive and T regs can block autoimmunity and are part of mum’s immune machinery that blocks mum rejecting dads bits in the unborn. Maybe this approach has mileage. Wonder if we would get a grant to test this hypothesis:-)
Where did the seminal fluid come from?.
It reminds me of a time in the Lab with MD2 when we were looking for a symptomatic treatment and as side effect of one drug we got covered, it was if we had given the beasties a Lad’s Mag….maybe we should have published this too.
"It reminds me of a time in the Lab with MD2 when we were looking for a symptomatic treatment and as side effect of one drug we got covered, it was if we had given the beasties a Lad's Mag….maybe we should have published this too"
Oh, happy days!
Maybe it was written by the same blokes who said that a curry and sex was a good way to bring on labour if you were pregnant and overdue
I think this is telling me that along with a good-quality diet and regular exercise, I should be having sex every day. This MS thing is really working out for my boyfriend.
Out of the kindness of my heart, I will begin offering free treatment to anyone with a bottle of wine who shows up at my apartment.