ArchiveOctober 2014

Migration shows early encounter with risk factor

ProfG made a post about the output of school kids and found that they seem to have a reduced output compared to non-Msers. Yes this is depressing, but the other part of the MS jigsaw is  if you look at the at who have were born in a low-risk area and moved to a high risk area like the UK. The answer appears to be move before 15 and you take the risk of birth place. Understanding MS means...

MouseDoctor-The Joker

Someone made a Complaint that I was a “Joker”. I wonder why you would think that?  🙂

P.S. You have freedoms to make comments but not to Insult. 
You may or may not like our styles or contents of the posts. If you no likey….no readie 🙂

So some don’t like “The Joker” They prefer Groucho Marx

IV IG making false positives for JC Virus

Kister I, Kuesters G, Chamot E, Omari M, Dontas K, Yarussi M, Subramanyam M, Herbert J. IV immunoglobulin confounds JC virus antibody serostatus determination. Neurol Neuroimmunol Neuroinflamm. 2014 Sep 18;1(3):e29. doi: 10.1212/NXI.0000000000000029. eCollection 2014 Oct. OBJECTIVE:To determine the impact of therapeutic infusion of IV immunoglobulin (IVIg) on John Cunningham virus antibody (JCV...

Natural History Studies

This is a retrospective study using the MS Registry in Kuwait. They took a cohort of patients and looked at certain variables to see if they were predictive of MS progression. The study is not revolutionary in its findings – it shows that a late age of onset, male gender and relapse frequency are all poor prognostic markers and increase the risk of progression to secondary-progressive MS...

Extended interval dosing of natalizumab

Bomprezzi R, Pawate S. Extended interval dosing of natalizumab: a two-center, 7-year experience. Ther Adv Neurol Disord. 2014;7(5):227-31 BACKGROUND:The enthusiasm for natalizumab, a highly efficacious agent in the treatment of multiple sclerosis (MS), has been tempered by the risks of progressive multifocal leukoencephalopathy associated with its use, and strategies to minimize those...

What is your experience of diagnosis

The folks at MS Trust have made some videos concerning diagnosis with MS…As ever the MSers are the stars. 1. What was your experience of diagnosis?   2. What were your feelings when you were given a diagnosis of MS?  and  3. Did anything change after you were diagnosed with MS? 4. How did family and friends respond to your diagnosis? 5. Did diagnosis with MS make any...

To deplete or not to deplete that is the question?

Leucopaenia (low white blood cell) has become a hot topic of the past week, with the realisation that people who get leucopaenia (low white blood cell counts) are more at risk from infection and the dreaded PML.  So now there  is a rush to stop the level of lymphopaenia from occurring, but one question is. Do we want our cake and eat it?Because we have to ask how do the MS-drugs stop MS...

More Epitopes to induce EAE and MS?

Novel pathogenic epitopes of myelin oligodendrocyte glycoprotein induce experimental autoimmune encephalomyelitis in C57BL/6 mice. Delarasse C, Smith P, Baker D, Amor S. Immunology. 2013 Dec;140(4):456-64. doi: 10.1111/imm.12155. Myelin oligodendrocyte glycoprotein (MOG), a minor protein of the central nervous system myelin, is recognized as a potential target in multiple sclerosis and...

Emoji Research

It seems that scientists are pretty rubbish in describing their work in language that the average person can read. So some are turning to the use of Emoji and using Emoticons to get across their message.  These are characters like the smiley face and people are using them to replace big words like “mouse” with pictures of mice. There is a even a Emoji Dictionary. Should we change...

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