ArchiveNovember 2014

VitaminD levels do not predict relapse after a baby

Runia TF, Neuteboom RF, de Groot CJ, de Rijke YB, Hintzen RQ.The influence of vitamin D on postpartum relapse and quality of life in pregnant multiple sclerosis patients. Eur J Neurol. 2014 Nov 28. doi: 10.1111/ene.12594. [Epub ahead of print] BACKGROUND AND PURPOSE: In relapsing-remitting MS patients, lower serum vitamin D concentrations are associated with higher relapse risk. In a number of...

ClinicSpeak: how important is your functional reserve?

Cerebellar abnormalities in early MS: the shredder may be quietly destroying your connections. #ClinicSpeak #MSResearch #MSBlog “The study below is very interesting in that it is applying new imaging technology to MS. It is using techniques to assess the connections of the so called cerebellar pathways in early MS. The cerebellum is the pathway that is mainly responsible for...

Stem cells inhibiting inflammatory attack

Epub: Li et al. The potential of human umbilical cord-derived mesenchymal stem cells as a novel cellular therapy for multiple sclerosis. Cell Transplant. 2014. Background: MS is a complex disease of neurological disability, affecting more than 300 out of every one million people in the world.  Aim: The purpose of the study was to evaluate the therapeutic effects of human umbilical...

LACTRIMS presentation on teriflunomide and alemtuzumab

Questions to ask yourself when interpreting the alemtuzumab phase 3 trial data. #LACTRIMS #MSBlog #MSResearch “As promised are the slides from the Genzyme symposium presented yesterday at LACTRIMS. The presentations were very data heavy and to help the attendees digest the data in their own time my co-presenter Professor Flavia Nelson has agreed for her slides to be uploaded with mine;...

ClinicSpeak: early treatment delays onset of SPMS

More data showing early access to DMTs is better than delayed access. #ClinicSpeak #MSBlog #MSResearch “The Scandinavian countries are blessed with data and the ability to collect it. Why? I suspect because it is cultural and happens at a national level. In Sweden virtually every MSer belongs to the national register and data is collected and added to this register annually. This substudy...

Blocking glutamate excitoxicity maybe a way to treat the inflammatory penumbra

Sulkowski G, Dąbrowska-Bouta B, Salińska E, Strużyńska L.Modulation of Glutamate Transport and Receptor Binding by Glutamate Receptor Antagonists in EAE Rat Brain.PLoS One. 2014 Nov 26;9(11):e113954. doi: 10.1371/journal.pone.0113954. eCollection 2014. The aetiology of multiple sclerosis (MS) is currently unknown. However, one potential mechanism involved in the disease may be excitotoxicity. The...

BartsMS Research Day 2015 -Should We have one?

Following on from the joint UCL research Day in June,  we are thinking about the return of Barts MS Research Day. The format must evolve & the venue from the Summer will change Can we afford to do it? Can we have it closer to home? What should we present? It is a Research Day that should present  our Research  and Not be Just an Information Day You want to know about...

ClinicSpeak: chickenpox and shingles in MSers treated with fingolimod

The problem of chickenpox and shingles on fingolimod and other DMTs. #ClinicSpeak #MSBlog #MSResearch “The article below on  Varicella-zoster virus (VZV) infection in MSers on fingolimod is timely and very relevant to field. VZV is a herpes virus  that causes chicken pox and once infected is responsible for recurrent localised infections called shingles. This study is...

Hot microglia in the white matter at first symptoms may give you an idea if MS diagnosis will follow

Giannetti P, Politis M, Su P, Turkheimer FE, Malik O, Keihaninejad S, Wu K, Waldman A, Reynolds R, Nicholas R, Piccini P. Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome. Brain. 2014 Nov 21. pii: awu331. [Epub ahead of print] The most accurate predictor of the subsequent development of multiple sclerosis in clinically isolated syndrome is the...

Politics: scientific impact, what is it?

How to measure scientific impact in the era of pop science? Will altmetric turn out to be a curse? #MSPolitics #MSResearch #MSBlog “Research impact; what does it mean? We as researchers are increasingly getting judged, and then hired and fired, based on our research performance. The 2014 UK research excellence framework (REF) include a metric on impact. We are told  that going forward...

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