ArchiveNovember 2014

VitaminD levels do not predict relapse after a baby

Runia TF, Neuteboom RF, de Groot CJ, de Rijke YB, Hintzen RQ.The influence of vitamin D on postpartum relapse and quality of life in pregnant multiple sclerosis patients. Eur J Neurol. 2014 Nov 28. doi: 10.1111/ene.12594. [Epub ahead of print] BACKGROUND AND PURPOSE: In relapsing-remitting MS patients, lower serum vitamin D concentrations are associated with higher relapse risk. In a number of...

Stem cells inhibiting inflammatory attack

Epub: Li et al. The potential of human umbilical cord-derived mesenchymal stem cells as a novel cellular therapy for multiple sclerosis. Cell Transplant. 2014. Background: MS is a complex disease of neurological disability, affecting more than 300 out of every one million people in the world.  Aim: The purpose of the study was to evaluate the therapeutic effects of human umbilical...

Blocking glutamate excitoxicity maybe a way to treat the inflammatory penumbra

Sulkowski G, Dąbrowska-Bouta B, Salińska E, Strużyńska L.Modulation of Glutamate Transport and Receptor Binding by Glutamate Receptor Antagonists in EAE Rat Brain.PLoS One. 2014 Nov 26;9(11):e113954. doi: 10.1371/journal.pone.0113954. eCollection 2014. The aetiology of multiple sclerosis (MS) is currently unknown. However, one potential mechanism involved in the disease may be excitotoxicity. The...

BartsMS Research Day 2015 -Should We have one?

Following on from the joint UCL research Day in June,  we are thinking about the return of Barts MS Research Day. The format must evolve & the venue from the Summer will change Can we afford to do it? Can we have it closer to home? What should we present? It is a Research Day that should present  our Research  and Not be Just an Information Day You want to know about...

Hot microglia in the white matter at first symptoms may give you an idea if MS diagnosis will follow

Giannetti P, Politis M, Su P, Turkheimer FE, Malik O, Keihaninejad S, Wu K, Waldman A, Reynolds R, Nicholas R, Piccini P. Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome. Brain. 2014 Nov 21. pii: awu331. [Epub ahead of print] The most accurate predictor of the subsequent development of multiple sclerosis in clinically isolated syndrome is the...

Modeling JCV virus infection

Kondo Y, Windrem MS, Zou L, Chandler-Militello D, Schanz SJ, Auvergne RM, Betstadt SJ, Harrington AR, Johnson M, Kazarov A, Gorelik L, Goldman SA.Human glial chimeric mice reveal astrocytic dependence of JC virus infection. J Clin Invest. 2014 Nov . pii: 76629. doi: 10.1172/JCI76629. [Epub ahead of print] Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease triggered...

Understanding MRI..the need for education

Brand J, Köpke S, Kasper J, Rahn A, Backhus I, Poettgen J, Stellmann JP, Siemonsen S, Heesen C.Magnetic Resonance Imaging in Multiple Sclerosis – Patients’ Experiences, Information Interests and Responses to an Education Programme. PLoS One. 2014 Nov 21;9(11):e113252 Background. Magnetic resonance imaging (MRI) is a key diagnostic and monitoring tool in multiple sclerosis (MS)...

T cell function after fingolimod

Chiarini M, Sottini A, Bertoli D, Serana F, Caimi L, Rasia S, Capra R, Imberti L.Newly produced T and B lymphocytes and T-cell receptor repertoire diversity are reduced in peripheral blood of fingolimod-treated multiple sclerosis patients. Mult Scler. 2014. pii: 1352458514551456. [Epub ahead of print] BACKGROUND:Fingolimod inhibits lymphocyte egress from lymphoid tissues, thus altering the...

Re(verse) Purposing to deliver MS drugs

I was giving a talk about animal models and their role in developing drugs to MS and I was asked by someone from Finland to post on this subject. As you may know only two drugs (out of about two thousand tried) have their routes in animal MS models and these are glaterimer acetate and Tysabri, where their action was first found in MS models. However in recent time I would bet that in most cases...

Risk of MS maybe not based on social statratification

Goulden R, Ibrahim T, Wolfson C. Is high socioeconomic status a risk factor for multiple sclerosis? A systematic review. Eur J Neurol. 2014 Nov 5. doi: 10.1111/ene.12586. [Epub ahead of print] High socioeconomic status (SES) is generally associated with better health outcomes, but some research has linked it with an increased risk of multiple sclerosis (MS). The evidence for this association is...

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