Abbey Bartlet: We had a deal!
President Josiah “Jed” Bartlet: Yes, we had a deal.
Abbey Bartlet: Yes, Jed. Look at me! Do you get that you have M.S.?
President Josiah “Jed” Bartlet: Abbey…
Abbey Bartlet: Do you get that your own immune system is shredding your brain? And I can’t tell you why. Do you have any idea how good a doctor I am and that I can’t tell you why?
President Josiah “Jed” Bartlet: I’ve had one episode in two years.
Abbey Bartlet: Yes, but relapsing-remitting M.S. can turn into secondary-progressive M.S. oftentimes ten years after the initial diagnosis which is exactly where we’ll be in two years! Do you know what that’s going to look like if it happens?
Abbey Bartlet: Memory lapses, loss of cognitive function, failure to reason, failure to think clearly. And I can’t tell you if it’s going to happen. I don’t know if it’s going to get better, I don’t know if it’s going to get worse. But we had a deal. And that deal is how you justified keeping it a secret from the world. It’s how you justified it to God… It’s how you justified it to me.
Epub: Aubert-Broche Bet al. Onset of multiple sclerosis before adulthood leads to failure of age-expected brain growth. Neurology. 2014 Nov 5. pii: 10.1212/WNL.0000000000001045.
METHODS: Whole brain and regional volumes of 36 RRMSers onset prior to 18 years of age were segmented in 185 longitudinal MRI scans (2-11 scans per participant, 3-month to 2-year scan intervals). MRI scans of 25 age- and sex-matched healthy normal controls (NC) were also acquired at baseline and 2 years later on the same scanner as the MS group. A total of 874 scans from 339 participants from the NIH-funded MRI study of normal brain development acquired at 2-year intervals were used as an age-expected healthy growth reference. All data were analyzed with an automatic image processing pipeline to estimate the volume of brain and brain substructures. Mixed-effect models were built using age, sex, and group as fixed effects.
RESULTS: Significant group and age interactions were found with the adjusted models fitting brain volumes and normalized thalamus volumes (p < 10-4). These findings indicate a failure of age-normative brain growth for the MS group, and an even greater failure of thalamic growth. In MSers, T2 lesion volume correlated with a greater reduction in age-expected thalamic volume. To exclude any scanner-related influence on our data, we confirmed no significant interaction of group in the adjusted models between the NC and NIH MRI Study of Normal Brain Development groups.
CONCLUSIONS: Our results provide evidence that the onset of MS during childhood and adolescence limits age-expected primary brain growth and leads to subsequent brain atrophy, implicating an early onset of the neurodegenerative aspect of MS.