EAE is rubbish again for finding drug responses

de Bruin NM, Schmitz K, Schiffmann S, Tafferner N, Schmidt M, Jordan H, Häußler A, Tegeder I, Geisslinger G, Parnham MJ. Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis. Behav Brain Res. 2015 Dec 12. pii: S0166-4328(15)30315-6. Experimental autoimmune encephalomyelitis (EAE) is a widely-used rodent...

Fat cells are not as good as thin stem cells

Strong AL, Bowles AC, Wise RM, Morand JP, Dutreil MF, Gimble JM, Bunnell BA.Human adipose stromal/stem cells from obese donors show reduced efficacy in halting disease progression in the experimental autoimmune encephalomyelitis model of multiple sclerosis.Stem Cells. 2015. doi: 10.1002/stem.2272. [Epub ahead of print] Multiple sclerosis is an autoimmune disease that affects the white matter of...

Shocking Proteins in Astrocyte in white matter demyelination

Peferoen LA, Gerritsen WH, Breur M, Ummenthum KM, Peferoen-Baert RM, van der Valk P, van Noort JM, Amor S. Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter. Acta Neuropathol Commun. 2015 Dec 22;3(1):87. INTRODUCTION:The important protective role of small heat-shock proteins (HSPs) in regulating cellular survival and migration...

The neuroinflammatory story in MS – astrocytes and B cells

van Luijn MM, van Meurs M, Stoop MP, Verbraak E, Wierenga-Wolf AF, Melief MJ, Kreft KL, Verdijk RM, ‘t Hart BA, Luider TM, Laman JD, Hintzen RQ. Elevated Expression of the Cerebrospinal Fluid Disease Markers Chromogranin A and Clusterin in Astrocytes of Multiple Sclerosis White Matter Lesions. J Neuropathol Exp Neurol. 2015. pii: nlv004. [Epub ahead of print] Using proteomics, we previously...

Doom and Gloom in the wake of Santa

Kavaliunas A, Wiberg M, Tinghög P, Glaser A, Gyllensten H, Alexanderson K, Hillert J. Earnings and Financial Compensation from Social Security Systems Correlate Strongly with Disability for Multiple Sclerosis Patients. PLoS One. 2015 22;10(12):e0145435. doi: 10.1371/journal.pone.0145435. eCollection 2015. BACKGROUND: Multiple sclerosis (MS) patients earn lower incomes and receive...



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