Archive2015

ResearchSpeak: lesions, relapses and disability outcomes

Do relapses matter more than silent MRI activity? #MSBlog #MSResearch #ResearchSpeak “This relatively small study of 111 pwMS demonstrates that with intermediate-term follow-up (mean of 8 years) the presence of Gd-enhancing, or active, lesions at baseline correlated with the subsequent number of relapses, but not with disability. Interestingly, only relapses, and not Gd-enhancing lesions...

EAE is rubbish again for finding drug responses

de Bruin NM, Schmitz K, Schiffmann S, Tafferner N, Schmidt M, Jordan H, Häußler A, Tegeder I, Geisslinger G, Parnham MJ. Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis. Behav Brain Res. 2015 Dec 12. pii: S0166-4328(15)30315-6. Experimental autoimmune encephalomyelitis (EAE) is a widely-used rodent...

PoliticalSpeak & OffLabel: New Year Resolution

Off-label prescribing; should it be one of our New Year’s resolutions? #PoliticalSpeak #MSBlog #OffLabel “On reflection one of the most important issues we have tried to address on this blog in 2015 is access to effective DMTs for people with MS (pwMS) who live in resource-poor settings. My personal experiences of what it is like to be a pwMS living in a resource...

Fat cells are not as good as thin stem cells

Strong AL, Bowles AC, Wise RM, Morand JP, Dutreil MF, Gimble JM, Bunnell BA.Human adipose stromal/stem cells from obese donors show reduced efficacy in halting disease progression in the experimental autoimmune encephalomyelitis model of multiple sclerosis.Stem Cells. 2015. doi: 10.1002/stem.2272. [Epub ahead of print] Multiple sclerosis is an autoimmune disease that affects the white matter of...

Shocking Proteins in Astrocyte in white matter demyelination

Peferoen LA, Gerritsen WH, Breur M, Ummenthum KM, Peferoen-Baert RM, van der Valk P, van Noort JM, Amor S. Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter. Acta Neuropathol Commun. 2015 Dec 22;3(1):87. INTRODUCTION:The important protective role of small heat-shock proteins (HSPs) in regulating cellular survival and migration...

The neuroinflammatory story in MS – astrocytes and B cells

van Luijn MM, van Meurs M, Stoop MP, Verbraak E, Wierenga-Wolf AF, Melief MJ, Kreft KL, Verdijk RM, ‘t Hart BA, Luider TM, Laman JD, Hintzen RQ. Elevated Expression of the Cerebrospinal Fluid Disease Markers Chromogranin A and Clusterin in Astrocytes of Multiple Sclerosis White Matter Lesions. J Neuropathol Exp Neurol. 2015. pii: nlv004. [Epub ahead of print] Using proteomics, we previously...

ClinicSpeak: treatment algorithms

Is it time to let AI (artificial intelligence) take-over clinical decision-making? #MSBlog #MSResearch #ClinicSpeak “Can we manage MS using a simple algorithm or flowchart? The review paper below suggests this is possible. I have always been reluctant to formulate algorithms; in my opinion there are simply too many personal decisions that need to be considered when choosing a treatment...

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