ArchiveJanuary 2015

Does having MS affect your children?

Razaz N, Tremlett H, Boyce WT, Guhn M, Joseph K, Marrie RA. Impact of parental multiple sclerosis on early childhood development: A retrospective cohort study. Mult Scler. 2015. pii: 1352458514559298. [Epub ahead of print] BACKGROUND:Exposure to parental chronic illness is associated with several adverse developmental outcomes.OBJECTIVES: We examined the association between parental multiple...

B cell depletion in progressive MS appears to be marginal

Castillo-Trivino T, Braithwaite D, Bacchetti P, Waubant E. Rituximab in relapsing and progressive forms of multiple sclerosis: a systematic review. PLoS One. 2013 ;8(7):e66308 BACKGROUND:Rituximab is an anti-CD20 monoclonal antibody approved for non Hodgkin lymphoma and rheumatoid arthritis. It is being considered for the treatment of MS.OBJECTIVES:To evaluate the efficacy and safety of...

Japanese MSers accumulate less disability

Piccolo L, Kumar G, Nakashima I, Misu T, Kong Y, Wakerley B, Ryan S, Cavey A, Fujihara K, Palace J. Multiple sclerosis in Japan appears to be a milder disease compared to the UK. J Neurol. 2015 Jan 22. [Epub ahead of print] Multiple sclerosis (MS) is relatively common in the West, but rare in Japan. In the literature, there are few comparative data regarding disease severity throughout...

Placebo and Nocbo effects

Bittar C, Nascimento OJ. Placebo and nocebo effects in the neurological practice.Arq Neuropsiquiatr. 2015 Jan;73(1):58-63. doi: 10.1590/0004-282X20140180. Epub 2015 Jan 1 Knowledge of placebo and nocebo effects is essential to identify their influence on the results in clinical practice and clinical trials, and thereby properly interpret their results. It is known that the gold standard of...

IS timing of Optic Neuritis eye damage and slow treatment why drugs are showing no effect

Gabilondo I, Martínez-Lapiscina EH, Fraga-Pumar E, Ortiz-Perez S, Torres-Torres R, Andorra M, Llufriu S, Zubuizarreta I, Saiz A, Sanchez-Dalmau B, Villoslada P.Dynamics of retinal injury after acute optic neuritis. Ann Neurol. 2015 Jan. doi: 10.1002/ana.24351. [Epub ahead of print] Background: We set out to assess the dynamics of retinal injury after acute optic neuritis (ON), and their...

B cells and their role in relapse

Hohmann C, Milles B, Schinke M, Schroeter M, Ulzheimer J, Kraft P, Kleinschnitz C, Lehmann PV, Kuerten S. Categorization of multiple sclerosis relapse subtypes by B cell profiling in the blood.Acta Neuropathol Commun. 2014 ;2(1):138. INTRODUCTION:B cells are attracting increasing attention in the pathogenesis of multiple sclerosis (MS). B cell-targeted therapies with monoclonal antibodies or...

Education: Multiple Sclerosis the facts you need to know

Light Reading from Canada  Some of you many find this Interesting (CLICK HERE) Pg97 Alternative Therapies “If you wanted to design a disease that is a charlatan’s dream, you could not do better than MS. It is a chronic illness with long periods of remission and occasional relapses. The cause is un- known and the treatment is far from satisfactory. Therefore, if you happen to give...

Getting rid of hot microglia

Airas L, Dickens A, Elo P, Marjamäki PM, Johansson J, Eskola O, Jones P, Trigg W, Solin O, Haaparanta-Solin M, Anthony D, Rinne J. In vivo Positron Emission Tomography Imaging Demonstrates Diminished Microglial Activation after Fingolimod Treatment in an Animal Model of Multiple Sclerosis. J Nucl Med. 2015 Jan 8. pii: jnumed.114.149955. [Epub ahead of print] There is a great need for the...

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