A major function of T helper (Th) 17 cells is to induce the production of factors that activate and mobilize neutrophils. Although Th17 cells have been implicated in the pathogenesis of multiple sclerosis (MS) and the animal model experimental autoimmune encephalomyelitis (EAE), little attention has been focused on the role of granulocytes in those disorders.
When first started MS research I was told that MS was a mononuclear (lymphocytes and macrophges) cell driven and that it was a white matter disease. So these bubbles get burst.
In mice it was always obvious that neutrophils were present in Lesions. In the HA mouse there were about 80% neutrophils in EAE lesions, in the ABH mouse there was less than 5% neutrophils, but they were within the cerebrospinal fluid. Immunology 101 of yesteryear said that mouse delayed hypersensititivty (T cell mediated allergic responses) reactions contained neutrophils which were not particularly common in rat or guinea pig EAE or MS.
In the C57BL/6 mouse it has recently been reported that TH17 T cells transfer EAE that is often atypical and causing disease in the cerebellum and having disease that contains neutrohils, compared to mononuclear cells in TH1 EAE.
In this study they find attractive proteins that attract neurtophils were present in the blood of MSers. Maybe they are important. It would be interesting to examine the effects in neuromyelitis optica, a demyelinating disease of optic nerve and spinal cord, where neutrophils are a problem.