ArchiveJanuary 2015

B cells and their role in relapse

Hohmann C, Milles B, Schinke M, Schroeter M, Ulzheimer J, Kraft P, Kleinschnitz C, Lehmann PV, Kuerten S. Categorization of multiple sclerosis relapse subtypes by B cell profiling in the blood.Acta Neuropathol Commun. 2014 ;2(1):138. INTRODUCTION:B cells are attracting increasing attention in the pathogenesis of multiple sclerosis (MS). B cell-targeted therapies with monoclonal antibodies or...

Education: Multiple Sclerosis the facts you need to know

Light Reading from Canada  Some of you many find this Interesting (CLICK HERE) Pg97 Alternative Therapies “If you wanted to design a disease that is a charlatan’s dream, you could not do better than MS. It is a chronic illness with long periods of remission and occasional relapses. The cause is un- known and the treatment is far from satisfactory. Therefore, if you happen to give...

ClinicSpeak: Helicobacter pylori infection might prove the hygiene hypothesis in MS

How convinced are you by the hygiene hypothesis? #MSBlog #MSResearch #ClinicSpeak “There is a theory that MS, and other putative autoimmune diseases, are due to excessive hygiene. The cleaner the environment you grow up in, the less infections you get as a child, the less your immune system gets educated by infections, the more likely it is your immune system will go awry when you are...

Getting rid of hot microglia

Airas L, Dickens A, Elo P, Marjamäki PM, Johansson J, Eskola O, Jones P, Trigg W, Solin O, Haaparanta-Solin M, Anthony D, Rinne J. In vivo Positron Emission Tomography Imaging Demonstrates Diminished Microglial Activation after Fingolimod Treatment in an Animal Model of Multiple Sclerosis. J Nucl Med. 2015 Jan 8. pii: jnumed.114.149955. [Epub ahead of print] There is a great need for the...

Survey results: why are MSers such risk takers?

I had no idea that MSers were such risk takers. #MSBlog #MSResearch “Live and learn something everyday. I am bowled over by the preliminary results of haemopoietic stem cell transplant (HSCT) survey. I had no idea how willing MSers are to accept unlicensed treatments, with evidence that is essentially multiple case series, rather than the gold-standard randomised controlled clinical trials...

Thalamic Brain lesions are associated with more mental problems in progressive MS

Thalamic lesions in multiple sclerosis by 7T MRI: Clinical implications and relationship to cortical pathology. Harrison DM, Oh J, Roy S, Wood ET, Whetstone A, Seigo MA, Jones CK, Pham D, van Zijl P, Reich DS, Calabresi PA.Mult Scler. 2015 Jan 12. pii: 1352458514558134. [Epub ahead of print] OBJECTIVE: Pathology in both cortex and deep gray matter contribute to disability in multiple...

What’s SA237

ProfG made a post on UCLP trials and mentioned a trial of NMO using SA237. Whats is this? It is monoclonal antibody that inhibited the interleukin 6 receptor Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. IL-6 is secreted by T cells and macrophages to stimulate immune response, e.g. during infection and after trauma...

ClinicSpeak: spinal fluid cells on natalizumab (Tysabri)

How much more do we have to learn about natalizumab? De-risking natalizumab. #MSBlog #MResearch #ClinicSpeak “The study below shows that natalizumab (Tysabri) does not have the same effect on the immune system in everyone on the drug. It shows that levels of the drug vary between individuals and the effect on immune surveillance of the central nervous system differs depending on levels of...

The centre of Immune tolerance

Safavi F, Li H, Gonnella P, Mari ER, Rasouli J, Zhang GX, Rostami A.c-kit plays a critical role in induction of intravenous tolerance in experimental autoimmune encephalomyelitis.Immunol Res. 2015 Jan 15. [Epub ahead of print] c-kit (CD117) is a tyrosine kinase receptor found in various types of immune cells. We examined the role of c-kit in autoantigen-induced i.v. tolerance in experimental...

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