ArchiveJanuary 2015

Thalamic Brain lesions are associated with more mental problems in progressive MS

Thalamic lesions in multiple sclerosis by 7T MRI: Clinical implications and relationship to cortical pathology. Harrison DM, Oh J, Roy S, Wood ET, Whetstone A, Seigo MA, Jones CK, Pham D, van Zijl P, Reich DS, Calabresi PA.Mult Scler. 2015 Jan 12. pii: 1352458514558134. [Epub ahead of print] OBJECTIVE: Pathology in both cortex and deep gray matter contribute to disability in multiple...

What’s SA237

ProfG made a post on UCLP trials and mentioned a trial of NMO using SA237. Whats is this? It is monoclonal antibody that inhibited the interleukin 6 receptor Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. IL-6 is secreted by T cells and macrophages to stimulate immune response, e.g. during infection and after trauma...

The centre of Immune tolerance

Safavi F, Li H, Gonnella P, Mari ER, Rasouli J, Zhang GX, Rostami A.c-kit plays a critical role in induction of intravenous tolerance in experimental autoimmune encephalomyelitis.Immunol Res. 2015 Jan 15. [Epub ahead of print] c-kit (CD117) is a tyrosine kinase receptor found in various types of immune cells. We examined the role of c-kit in autoantigen-induced i.v. tolerance in experimental...

Occurrence of Tremor in USA

Rinker JR 2nd, Salter AR, Walker H, Amara A, Meador W, Cutter GR. Prevalence and characteristics of tremor in the NARCOMS multiple sclerosis registry: a cross-sectional survey. BMJ Open. 2015;5(1):e006714. doi: 10.1136/bmjopen-2014-006714. OBJECTIVES:(1)To describe the prevalence and severity of tremor in patients with multiple sclerosis (MS) registered within a large North American MS registry;...

Converting to MS…Is IL-8 a biomarker

Rossi S, Motta C, Studer V, Macchiarulo G, Germani G, Finardi A, Furlan R, Martino G, Centonze D. Subclinical central inflammation is risk for RIS and CIS conversion to MS.Mult Scler. 2015 Jan 12. pii: 1352458514564482. [Epub ahead of print] BACKGROUND: Subtle diffuse intrathecal inflammation is undetectable by conventional neuroimaging, and could influence multiple sclerosis (MS) disease...

Your View of Progress on Progression

Based on your comments today on the progress of developing treatments “Slow? Like a tortoise with no legs with Prof Mouse sitting on its back”.

Cheers mates:-)..Still remember.. who won the race? the hare? the tortoise? or the tortoise with no legs? 

Science is about adapting to make change:-)

People in China don’t Convert

Peng JT, Cong HR, Yan R, Kong XY, Jiang HQ, Wei WB, Zhang XJ.Neurological outcome and predictive factors of idiopathic optic neuritis in China. J Neurol Sci. 2014. pii: S0022-510X(14)00796-5. doi: 10.1016/j.jns.2014.12.031. [Epub ahead of print] BACKGROUND:The neurological outcome and predictive factors of idiopathic optic neuritis (ION) in China are largely unknown.OBJECTIVE:The aim of this...

promoting remyelintion

Wegener A, Deboux C, Bachelin C, Frah M, Kerninon C, Seilhean D, Weider M, Wegner M, Nait-Oumesmar B. Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination.Brain. 2015 Jan;138(Pt 1):120-35. doi: 10.1093/brain/awu375. The basic helix-loop-helix transcription factor Olig2 is a key determinant for the specification of neural precursor cells into oligodendrocyte progenitor...

Progression despite transplantion of stem cells

Curro’ D, Vuolo L, Gualandi F, Bacigalupo A, Roccatagliata L, Capello E, Uccelli A, Saccardi R, Sormani MP, Mancardi G.Low intensity lympho-ablative regimen followed by autologous haematopoietic stem cell transplantation in severe forms of multiple sclerosis: A MRI-based clinical study.Mult Scler. 2015 Jan 12. pii: 1352458514564484. [Epub ahead of print] BACKGROUND:Autologous hematopoietic...

The benefits of exercise in MS – the results speak for themselves

A pilot study of an exercise-based patient education program in people with multiple sclerosis. Kersten S, Mahli M, Drosselmeyer J, Lutz C, Liebherr M, Schubert P, Haas CT. Mult Scler Int. 2014;2014:306878. doi: 10.1155/2014/306878. Epub 2014 Dec 21.   Abstract There is increasing evidence that physical exercise leads to numerous positive effects in PwMS. However, long-term effects of...

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