ArchiveFebruary 2015

CrowdSpeak: we need a new name for the Charcot 2 trial

How are your creative skills? Can you come up with a better name than HEART? #CrowdSpeak #MSBlog #MSResearch “Since launching our crowdsourcing project and proposing the anti-EBV/HAART study we have a few complaints about the acronym HEART. Can you come-up with something better? Something more catchy?” “Our survey remains open and we have expanded the number...

ClinicSpeak: risk of stopping natalizumab

How to prevent getting worse when stopping natalizumab. #ClinicSpeak #MSResearch #MSBlog “A critical issue in MS with regard to risk:benefit assessment of DMTs (disease-modifying therapies) is the short-change we give to the risk of MS. This real-life data study below shows that when we de-risk PML by taking MSers off natalizumab, we increase their risk of becoming more disabled. If you are...

Genetics of thin brains give ideas to control progression

Matsushita T, Madireddy L, Sprenger T, Khankhanian P, Magon S, Naegelin Y, Caverzasi E, Lindberg RL, Kappos L, Hauser SL, Oksenberg JR, Henry R, Pelletier D, Baranzini SE. Genetic associations with brain cortical thickness in multiple sclerosis.Genes Brain Behav. 2015. doi: 10.1111/gbb.12190. [Epub ahead of print] Multiple sclerosis (MS) is characterized by temporal and spatial dissemination...

CrowdSpeak: the rationale behind Charcot 2 or the HEART study

What is the rationale behind the HEART trial? #CrowdSpeak #MSBlog #MSResearch “Some of you have asked about the scientific rationale behind Charcot 2. If you have been reading this blog for sometime you will have noticed a theme emerging around viruses and MS. There is now compelling evidence that EBV and HERVs (human endogenous retroviruses) are involved in MS. Some of us in the community...

Shift work gives you MS

Hedström A, Åkerstedt T, Olsson T, Alfredsson L.Shift work influences multiple sclerosis risk. Mult Scler. 2015 Feb. pii: 1352458514563592. [Epub ahead of print] BACKGROUND:An association between working shift at a young age and subsequent risk for multiple sclerosis (MS) has been observed.OBJECTIVE:To investigate whether this finding could be replicated, and to further explore the influence...

Causing MS by blockade of TNF

Napolitano M, Balato N, Ayala F, Cirillo T, Balato A. Multiple sclerosis following anti-tumor necrosis factor-alpha therapy for psoriasis: First case in Italy? Case report and review of the literature. G Ital Dermatol Venereol. 2015 Feb 18. [Epub ahead of print] The use of Tumor Necrosis Factor alpha (TNF–α) antagonists has profoundly improved clinical management of psoriasis and other...

CrowdSpeak: preparing for Charcot 2

What do you think about the HEART trial? Have your say. #CrowdSpeak #MSBlog #MSResearch “Thank you for engaging with the our tentative exploration into the Crowdfunding space. It looks as if the Charcot Project has the most support. As this initiative is to enable a second phase 2 trial targeting both EBV and HERVs (human endogenous retroviruses) in MS we have made a start on preliminary...

MS doesn’t stop you getting pregnant

Roux T, Courtillot C, Debs R, Touraine P, Lubetzki C, Papeix C. Fecundity in women with multiple sclerosis: an observational mono-centric study.  J Neurol. 2015. [Epub ahead of print] Multiple sclerosis (MS) is a neurological disease mostly affecting women of childbearing age. When counseling MS patients, many questions arise on the reciprocal influence of MS and pregnancy. However...

Should animal studies be run like human clinical trials?

Some people think that animal studies should be like clinical trials and registered in a public data base before the work is done. This was the idea at a science meeting that I have recently attended If you are a research scientist you would have to say what you are doing before you do it, what would be the primary outcome that you want to find and you would say how you are going to do it so you...

Parasite eggs not much use in controlling MS

Voldsgaard A, Bager P, Garde E, Åkeson P, Leffers A, Madsen C, Kapel C, Roepstorff A, Thamsborg S, Melbye M, Siebner H, Søndergaard H, Sellebjerg F, Sørensen PS.Trichuris suis ova therapy in relapsing multiple sclerosis is safe but without signals of beneficial effect. Mult Scler. 2015. pii: 1352458514568173. [Epub ahead of print] BACKGROUND: An observational study has suggested that...

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