ArchiveFebruary 2015

CrowdSpeak: playing catch-up

Should we adopt an all-or-nothing crowdfunding model? #CrowdSpeak #MSBlog #MSResearch “The following article in last month’s Nature Medicine summarises very succinctly what is happening in the crowd-funding space. It looks as if we are coming to the party late and playing catch-up. I have highlighted some key aspects in bold in excerpts from the article. Based on our survey...

Peoples Strictly-Vote Trishna

#MS Research Vote #Trisha @ #Peoples Strictly Six inspirational but everyday heroes and heroines have been confirmed to take part in BBC One’s The People’s Strictly for Comic Relief and fulfil every Strictly fan’s dream. Whilst we should remain impartial…sod it..Come On Trishna! For a Non-British Audience how do you describe Peoples Strictly.  Well it is a twist of a television light...

TeamG news developing drugs

As soon as we published the prospect of developing a new drug for symptom control. You said “As Del Boy (Prof G) said to Rodney (Prof M) – we’ll be millions. I better invest in beer companies and heavy metal record labels for when you hit the big time. Prof G can give his countryman Berlosconi a run for his money”. Maybe we are psychic, as I made this figure last weekend...

TeamG Research is not all esoterric

MD2 in response to a comment recently (16:2:2015) wrote “we have some great research coming down the pipe that will stick two fingers up to the negative crowd;-)”                              Today is the part of the proof …but these two fingers are not exactly the response I was thinking:-).  But...

TeamG Research from Idea to MSers

#MSResearch #MSBlog. TeamG & Friends develop new MS drug for #spasticity Many blog sites get conned into doing advertising for Company X or Company Y following press releases by announcing that Company X or Company Y, will start trials in MS as soon as they have financing, hoping for some more shareholder investment. So now is the time to make a company pitch, but we are not after your money...

ClinicSpeak: steroid use and breast feeding

Pulsed high-dose steroids are safe during breast feeding. #ClinicSpeak #MSBlog #MSResearch “The case study below of a lactating MSer treated with high-dose intravenous steroids for a relapse shows that only a small amount of the actual steroids crosses over into the breast milk. The actual dose the baby gets from breast feeding is low. Women MSers who want to start or extend their families...

Diagnosis is it time for an update?

Caucheteux N, Maarouf A, Genevray M, Leray E, Deschamps R, Chaunu MP, Daelman L, Ferré JC, Gout O, Pelletier J, Pierot L, Edan G, Tourbah A. Criteria improving multiple sclerosis diagnosis at the first MRI. J Neurol. 2015 Feb [Epub ahead of print] The introduction of the McDonald criteria has enabled earlier diagnosis of multiple sclerosis (MS). However, even with the 2010 revised...

Is MS starving the brain?

Impaired Cerebrovascular Reactivity in Multiple Sclerosis Olga Marshall, MS; Hanzhang Lu, PhD; Jean-Christophe Brisset, PhD; Feng Xu, PhD; Peiying Liu, PhD; Joseph Herbert, MD; Robert I. Grossman, MD; Yulin Ge, MD JAMA Neurol. 2014;71(10):1275-1281. doi:10.1001/jamaneurol.2014.1668 IMPORTANCE  Cerebrovascular reactivity (CVR) is an inherent indicator of the dilatory capacity of cerebral...

Producing oligodendrocytes with SOX

Elevated In Vivo Levels of a Single Transcription Factor Directly Convert Satellite Glia into Oligodendrocyte-like Cells.,Weider M, Wegener A, Schmitt C, Küspert M, Hillgärtner S, Bösl MR, Hermans-Borgmeyer I, Nait-Oumesmar B, Wegner M. PLoS Genet. 2015;11(2):e1005008.  Oligodendrocytes are the myelinating glia of the central nervous system and ensure rapid saltatory conduction...

ClinicSpeak: reducing interferon injection reactions

Will reducing injection site reactions resuscitate IFNbeta as a DMT for MS? #ClinicSpeak #MSBlog #MSResearch “Is there life in the old horse yet? The following study shows that the topical application of a cream that contains vitamin K reduces interferon-beta injections site reactions. How? Vitamin K is thought to act on the production of coagulation factors that are implicated in a...

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