Sledgehammer to Crack a Nut

You say MS many treatments are sledgehammers to crack a nut!

You are correct, but that is all we have at the moment, Until we have more specific targets, these come with side effects the bigger the sledgehammer the more side effects……When to use them as the nuts can get big…..too big

Think… No Evident Disease Activity. Is this nuts?

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  • Mouse,

    I really don't mind the sledgehammer approach as long as it works. Late stage MS is a no-no for me so a cocktail of chemo drugs doesn't worry me that much. In an ideal world a safe, targeted, highly effective drug would be great, but (I) your mice keep letting us down and (II) Prof G has swapped his labcoat for a pair of speedos. Until you get some decent mice and Prof G rejoins the workforce, we are stuck with the sledgehammer.

  • So true I think and hope products like genbac1 geneuro and something hopefully out of the charcot project could be genuine nutcrackers. But right now it's hammertime :)!

  • Wow. You're wasted in medicine with those art skills!! 🙂

    For me, MS treatments are a bit like making chicken for dinner. I can live with over-cooking it – that's just an inconvenience. But if I undercook it, I'm likely to end up in a sh1tty mess.

    No disrespect intended, but you guys and Prof G can afford to be a bit more whimsical about it. Back a turkey and you can reset the clock and go again with a new mouse and a new drug. No bother.

    If an MS'er backs a turkey, they're risking life in a wheelchair and financial ruin. No chance to reset the clock for us.

    So until you guys nail with some considerable certainty the exact subsets of cells responsible, and how much is "just enough" to deplete them, I'm comfortable to keep smashing the lot with a sledgehammer.

    I'm intending to patent this as the poultry-sledgehammer hypothesis.

    • Don't bother….. public disclosure, which you have just done, kills your patent opportunity- your invention and novelty have been blown:-…in USA to can talk first, patent later but not in Europe, without worldwide coverage the patent is rather useless. I the US it is easier to get ideas only patents, without providing evidence.

      When you travel for you chicken, you have to watch out it is not rat:-), after all the Great British public can't tell the difference between eating horse and beef:-).

    • The real problem is actually that most MS treatments currently available are more like PALTRY sledgehammers – mostly with dodgy handles which can fly off and do a whole heap more damage – despite the best efforts of Meeces and Profs to come up with better sledgehammers……………………….

      And just recently a whole truck load (literally) of live caged cats, some of which were injured, was seized on its way to supply said felines to the restaurant tables of some Asian country. At least the poor furries were subsequently euthanased by the authorities – hopefully humanely. And Yes, I said Cats, not rats.

    • Anon at 11.25am here again
      Absolutely do not give up MD2 – I'll just have to blame my comment on an MS moment which failed to stop the fingers from hitting the keyboard – an irresistible urge that could not pass up an opportunity for a bit of word play and a bad pun. I would not follow this blog at all if I thought that what Team G et al were doing was not worthwhile.

      The cat story is apparently true though, and guinea pigs used to be a significant protein source in parts of south America (maybe they still are…)

    • No problem, we all have those moments, you don't have to have MS to have one! We get a few comments dissing our experimental work and sometimes I get a sense of humour failure. I think we are getting to the point where will start to move from the sledgehammer to the tack hammer.
      The cat story is horrendous.
      I think they still eat guinea pigs in parts of South America.

    • Yep you can get Cavy (Guinea pig) on the menu in south america. Unlike alot of animals that run when they hear a load noise, guinea pigs freeze… quite easy to shoot. P.S. Before he RSPCA descends they are lovely little animals and would have so much to offer MS research now as we need good chronic demyelination models, which the mice and rats aren't, however who works with them these days nobody i know.

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