ArchiveMarch 2015

Another growth factor for oligodendrocytes

Hammond E, Lang J, Maeda Y, Pleasure D, Angus-Hill M, Xu J, Horiuchi M, Deng W, Guo F. The Wnt Effector Transcription Factor 7-Like 2 Positively Regulates Oligodendrocyte Differentiation in a Manner Independent of Wnt/β-Catenin Signaling.J Neurosci. 2015;35:5007-22. Genetic or pharmacological activation of canonical Wnt/β-catenin signaling inhibits oligodendrocyte differentiation. Transcription...

Cognition in Progressive MS – a hard nut to crack!

J Neurol Sci. 2015 Mar 3. pii: S0022-510X(15)00124-0. doi: 10.1016/j.jns.2015.02.044. [Epub ahead of print] Orienting network dysfunction in progressive multiple sclerosis. Ayache SS, Palm U, Chalah MA, Nguyen R, Farhat WH, Créange A, Lefaucheur JP. Among patients with multiple sclerosis (MS), cognitive impairment affects up to 70% of the population . The most frequently impaired domains are...

Cortical; Relapses

Puthenparampil M, Poggiali D, Causin F, Rolma G, Rinaldi F, Perini P, Gallo P.Cortical relapses in multiple sclerosis. Mult Scler. 2015. pii: 1352458514564483. [Epub ahead of print] BACKGROUND:Multiple sclerosis (MS) is a white and grey matter disease of the central nervous system (CNS). It is recognized that cortical damage (i.e. focal lesions and atrophy) plays a role in determining the...

Breast feeding and MS

Ragnedda G, Leoni S, Parpinel M, Casetta I, Riise T, Myhr KM, Wolfson C, Pugliatti M. Reduced duration of breastfeeding is associated with a higher risk of multiple sclerosis in both Italian and Norwegian adult males: the EnvIMS study.J Neurol. 2015. [Epub ahead of print]Breastfeeding for at least 4 months has been found to be associated with a reduced risk of immune-mediated diseases...

Progressive MS trials are like buses you wait ages for one and then two come at the same time

Whilst  I appreciate that maybe our car-loving readers may not get the concept of two buses coming at the same time when you have been waiting ages for one, it is funny that this is just what is happening in progressive MS.  We have to take the 55 bus or the 205 bus each day or walk 2-3 miles (~4-5km) to see the beasties, some times multiple times a day The idea of MS-SMART trials was...

My biomarker wishlist for the MS-SMART study

Those of you I met and talked to at the ‘MS Research Day’ on the 21.3.2015 would already know that my field of work is on biomarkers – specifically biological markers found in bodily fluids. A biomarker is “a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacologic responses to a...

How do like your pills?

Wicks P, Brandes D, Park J, Liakhovitski D, Koudinova T, Sasane R.Preferred features of oral treatments and predictors of non-adherence: two web-based choice experiments in multiple sclerosis patients. Interact J Med Res. 2015;4(1):e6. doi: 10.2196/ijmr.3776. BACKGROUND:Oral disease modifying therapies (DMTs) for multiple sclerosis (MS) differ in efficacy, tolerability, and safety...

Treatment inhibits the formation of cortical lesions

Rinaldi F, Perini P, Atzori M, Favaretto A, Seppi D, Gallo P. Disease-modifying drugs reduce cortical lesion accumulation and atrophy progression in relapsing-remitting multiple sclerosis: results from a 48-month extension study. Mult Scler Int. 2015;2015:369348. doi: 10.1155/2015/369348. Epub 2015 Feb 23. Cortical lesions (CLs) and atrophy are pivotal in multiple sclerosis (MS)...

The chronicles get a new story

Now that some of you know what this is all about……..

No Comments Needed..Thanks.

You had to be at the Research Day to Find out.

What happened at the Research Day…Stays at the Research Day:-(

All will be revealed soon I suspect.

Education: Don’t believe every thing you read.

#MS Research. Animal studies trend to go more trial-like. I was asked this week what sources of information do you trust. I said definitely not the media…..and the best judgement is to learn the science and read the papers yourself. However, this is not easy especially if you learn bad practises. There has been a trend to make animal studies more like clinical studies. Whilst the...

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