ArchiveMarch 2015

ClinicSpeak: psychiatric comorbidity

Do you suffer from anxiety, depression or substance misuse? #ClinicSpeak #MSBlog #MSResearch “The meta-analysis below confirms what we know; MSers are likely to have a high rate of psychiatric co-morbidity. This includes depression, anxiety and alcohol and substance abuse. Psychiatric comorbidity is the hidden, often ignored, underbelly of MS. Anxiety and fatigue are so common that...

Treatment inhibits the formation of cortical lesions

Rinaldi F, Perini P, Atzori M, Favaretto A, Seppi D, Gallo P. Disease-modifying drugs reduce cortical lesion accumulation and atrophy progression in relapsing-remitting multiple sclerosis: results from a 48-month extension study. Mult Scler Int. 2015;2015:369348. doi: 10.1155/2015/369348. Epub 2015 Feb 23. Cortical lesions (CLs) and atrophy are pivotal in multiple sclerosis (MS)...

The chronicles get a new story

Now that some of you know what this is all about……..

No Comments Needed..Thanks.

You had to be at the Research Day to Find out.

What happened at the Research Day…Stays at the Research Day:-(

All will be revealed soon I suspect.

ClinicSpeak: MS comorbidities

A focus on MS comorbidities; at least it is something we can target in progressive MS. #ClinicSpeak #MSBlog #MSResearch “I  have just arrived in Toronto to attend, and speak at, the NMSS-ECTRIMS Comorbidities meeting. The programme below may be of interest to you. What is a comorbidity?  The following is a reasonable working definition: ‘In medicine...

Death of the Cord lets hit RIP to get oligos to live

Ofengeim D, Ito Y, Najafov A, Zhang Y, Shan B, DeWitt JP, Ye J, Zhang X, Chang A, Vakifahmetoglu-Norberg H, Geng J, Py B, Zhou W, Amin P, Lima JB, Qi C, Yu Q, Trapp B, Yuan J. Activation of Necroptosis in Multiple Sclerosis. Cell Rep. 2015 Mar 17. pii: S2211-1247(15)00209-0. doi: 10.1016/j.celrep.2015.02.051. [Epub ahead of print] Multiple sclerosis (MS), a common neurodegenerative...

Education: Don’t believe every thing you read.

#MS Research. Animal studies trend to go more trial-like. I was asked this week what sources of information do you trust. I said definitely not the media…..and the best judgement is to learn the science and read the papers yourself. However, this is not easy especially if you learn bad practises. There has been a trend to make animal studies more like clinical studies. Whilst the...

Neuroprotection and regeneration is this the new way forward

Targeting Repulsive Guidance Molecule A to Promote Regeneration and Neuroprotection inMultiple Sclerosis.Demicheva E, Cui YF, Bardwell P, Barghorn S, Kron M, Meyer AH, Schmidt M, Gerlach B, Leddy M, Barlow E, O’Connor E, Choi CH, Huang L, Veldman GM, Rus H, Shabanzadeh AP, Tassew NG, Monnier PP, Müller T, Calabresi PA, Schoemaker H, Mueller BK. Cell Rep. 2015  pii: S2211...

CrowdSpeak: What has happened to the Charcot Project?

The Charcot Project is alive and kicking. #CrowdSpeak #MSBlog #MSResearch “The first study done under the Charcot umbrella, the INSPIRE or raltegravir trial, finished last year. Our University or sponsor of the study will not allow us to analyse the results until the database is locked. Unfortunately, these are the rules that the MHRA (The Medicines and Healthcare...

Animal studies going one way or the other.

Ding X, Yan Y, Li X, Li K, Ciric B, Yang J, Zhang Y, Wu S, Xu H, Chen W, Lovett-Racke AE, Zhang GX, Rostami A. Silencing IFN-γ Binding/Signaling in Astrocytes versus Microglia Leads to Opposite Effects on Central Nervous System Autoimmunity. J Immunol. 2015 pii: 1303321. [Epub ahead of print] IFN-γ, the hallmark cytokine of Th1 cells, plays an important role in experimental autoimmune...

Brain training..can you remember?

You asked “Do you write puzzles” for those of you who have been visiting the blog for some time, can you remember this picture from brain training done some time ago? I wonder if Tony Fonda (Blogger) remembers saying: ‘Moqtada Sadr was having Fish for dinner when he read in the Newspaper that Jimmy Carter (White man’s Caricature) had plans with the Saudis (Bearded guy to...



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