Recognition of myelin by CD8 T cells nerves

Reuter E, Gollan R, Grohmann N, Paterka M, Salmon H, Birkenstock J, Richers S, Leuenberger T, Brandt AU, Kuhlmann T, Zipp F, Siffrin V. Cross-Recognition of a Myelin Peptide by CD8+ T Cells in the CNS Is Not Sufficient to Promote Neuronal Damage. J Neurosci. 25;35(12):4837-50

Multiple sclerosis (MS) is an inflammatory disease of the CNS thought to be driven by CNS-specific T lymphocytes. Although CD8(+) T cells are frequently found in multiple sclerosis lesions, their distinct role remains controversial because direct signs of cytotoxicity have not been confirmed in vivo. In the present work, we determined that mouse ovalbumin-transgenic (OT-1) CD8(+) T cells recognize the myelin peptide myelin oligodendrocyte glycoprotein 40-54 (MOG40-54) both in vitro and in vivo. 

The aim of this study was to investigate whether such cross-recognizing CD8(+) T cells are capable of inducing CNS damage in vivo. Using intravital two-photon microscopy in the mouse model of multiple sclerosis, we detected antigen recognition motility of the OT-1 CD8(+) T cells within the CNS leading to a selective enrichment in inflammatory lesions. However, this cross-reactivity of OT-1 CD8(+) T cells with MOG peptide in the CNS did not result in clinically or subclinically significant damage, which is different from myelin-specific CD4(+) Th17-mediated autoimmune pathology. Therefore, imaging demonstrates that local myelin recognition by autoreactive CD8(+) T cells in inflammatory CNS lesions alone is not sufficient to induce disability or increase axonal injury.

This study looks at CD8+ T cells whichare common in MS and suggests the presence of virus somewhere as CD8 cells are killers of virally infected cells. This study acts if a cell is reactive to one target in this case an ovalbumin (albumin from an egg) specific T cell can also react with a myelin protein. The question is does it cause damage and this is how autoimmunity occurs. They transfer these cells into mice and nothing much happens. Does this mean CD8 T cells aren’t killing oligodendrocytes and destroying myelin.
In order to kill a target CD8 T cells much recognise their target in the presence of major hisotocompatibility class I

Nerves and cells within the CNS down regulate MHC class I, so without enough of this then oligodendrocytes and nerves are not going to be much of a target and not much damage is going to occur may this happened here.

 Are the CD8

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  • I think it has been shown in the past that the repertoire of autoreactive immune cells is no different in healthy people compared to people with MS.

    So it seems there are other mechanisms involved that leads to autoimmunity. Some researchers believe that the immune system does not exist autonomously and the nervous system has control over the immune system and vice versa.

    I believe here lies the root of what causes MS and there is a lot of evidence to support this point of view:

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