ArchiveJuly 2015

The MPs response to the Off Patent Drugs Bill

This the response by my MP “Thank you for contacting me recently regarding the Off-Patent Drugs Bill [and the related ‘unlock drugs’ campaign by Breast Cancer Now]. I appreciate the frustration and concern that many people feel about the delays that can occur in accessing new and potentially effective drugs and treatments. I also appreciate that through their ‘Unlock...

A hammer to crack a nut, is it nuts to think that immunosupressives do not cause PML

Van Schependom J, Gielen J, Laton J, Nagels G. Assessing PML risk under immunotherapy: if all you have is a hammer, everything looks like a nail. Mult Scler. 2015 pii: 1352458515596458. [Epub ahead of print] Recently, three progressive multifocal leukoencephalopathy (PML) cases have been reported in multiple sclerosis (MS) patients, two treated with fingolimod (Gilenya, Novartis), the third with...

Why Barts MS not Queen Mary

What should we be called? This is an ongoing cause of contention between Queen Mary University of London and its medical school Barts and the London School of Medicine and Dentistry.                                 Why Barts MS Queen Mary University of London (officially abbreviated to QMUL, informally known as...

A classification system for science news

A classification system for science news. I have lifted this piece from the Guardian and covers something that I was considering when I first started blogging. Science news and articles are becoming increasingly popular, but with so much being written about so many things, it can be confusing for the beginner science enthusiast to grasp what they’re reading and how to interpret it. ...

Have a more powerful tool and you see more

Dula AN, Pawate S, Dortch RD, Barry RL, George-Durrett KM, Lyttle BD, Dethrage LM, Gore JC, Smith SA. Magnetic resonance imaging of the cervical spinal cord in multiple sclerosis at 7T. Mult Scler. 2015. pii: 1352458515591070. [Epub ahead of print] BACKGROUND: The clinical course of multiple sclerosis (MS) is mainly attributable to cervical and upper thoracic spinal cord dysfunction. High...

What’s in a Name

Dear All Thank you for voting for the Survey…What’s in a name.  If you haven’t done it sign up to MS Register in the UK, and  NARCOMS in North America.                                                         I will post...

MS Basics – SPASTICITY

I promised to post on spasticity in MS a while back. Hope you find this post useful… Firstly, here is the wikepedia version [click]. And now mine – as clinicians when we say there’s spasticity in an arm/leg we mean that there’s increased resistance to movement of the arm/leg at the level of it’s joint. For example, this is the knee joint for the lower leg, or the hip...

EBV-specific CD8 cells in CSF

van Nierop GP, Mautner J, Mitterreiter JG, Hintzen RQ, Verjans GM. Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins.Mult Scler. 2015 Jun 3. pii: 1352458515588581. [Epub ahead of print] BACKGROUND:The association between Epstein-Barr virus (EBV) and multiple sclerosis (MS) may involve intrathecal EBV-specific T-cell responses targeting the...

CD52 depletion inhibits EAE

Turner MJ, Pang PT, Chretien N, Havari E, LaMorte MJ, Oliver J, Pande N, Masterjohn E, Carter K, Reczek D, Brondyk W, Roberts BL, Kaplan JM, Siders WM. Reduction of inflammation and preservation of neurological function by anti-CD52 therapy in murine experimental autoimmune encephalomyelitis. J Neuroimmunol. 2015;285:4-12. Alemtuzumab, a monoclonal antibody directed against human CD52, is used in...

Fingolimod inhibits cellular migration across the blood brain barrier

Spampinato SF, Obermeier B, Cotleur A, Love A, Takeshita Y, Sano Y, Kanda T, Ransohoff RM. Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli? PLoS One. 2015;10(7):e0133392. The ability of the Blood Brain Barrier (BBB) to maintain proper barrier functions, keeping an optimal...

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