ArchiveJuly 2015

The MPs response to the Off Patent Drugs Bill

This the response by my MP “Thank you for contacting me recently regarding the Off-Patent Drugs Bill [and the related ‘unlock drugs’ campaign by Breast Cancer Now]. I appreciate the frustration and concern that many people feel about the delays that can occur in accessing new and potentially effective drugs and treatments. I also appreciate that through their ‘Unlock...

A hammer to crack a nut, is it nuts to think that immunosupressives do not cause PML

Van Schependom J, Gielen J, Laton J, Nagels G. Assessing PML risk under immunotherapy: if all you have is a hammer, everything looks like a nail. Mult Scler. 2015 pii: 1352458515596458. [Epub ahead of print] Recently, three progressive multifocal leukoencephalopathy (PML) cases have been reported in multiple sclerosis (MS) patients, two treated with fingolimod (Gilenya, Novartis), the third with...

ClinicSpeak: derisking natalizumab

De-risking natalizumab has not proved as simple as I had expected. #ClinicSpeak #MSBlog #MSResearch How do you switch from natalizumab to alemtuzumab? #ClinicSpeak #MSBlog #MSResearch “At Barts-MS we are trying to de-risk natalizumab-treated MSers as much as possible. Now that we have other options for MSers why would anyone want to stay on natalizumab who is JCV seropositive? In...

Novartis maybe now believes Biogen. Fingolimod does not promote remyelination

Alme MN, Nystad AE, Bø L, Myhr KM, Vedeler CA, Wergeland S, Torkildsen Ø. Fingolimod does not enhance cerebellar remyelination in the cuprizone model. J Neuroimmunol. 2015  15;285:180-6.Fingolimod (FTY720) is approved for treatment of relapsing-remitting multiple sclerosis. In vitro studies have found that fingolimod stimulates remyelination in cerebellar slices, but in vivo animal...

Why Barts MS not Queen Mary

What should we be called? This is an ongoing cause of contention between Queen Mary University of London and its medical school Barts and the London School of Medicine and Dentistry.                                 Why Barts MS Queen Mary University of London (officially abbreviated to QMUL, informally known as...

ClinicSpeak: poor recovery from relapses predict progression

Are you a good, or bad, recoverer from relapses? #ClinicSpeak #MSBlog #MSResearch “The study below shows that if you have a poor recovery from relapses you are much more likely to enter the clinically-apparent progressive phase of the disease sooner; in fact in this study it was ~22 years sooner (8.3 years vs. 30.2 years). These results are important for several reasons: Firstly, it is...

A classification system for science news

A classification system for science news. I have lifted this piece from the Guardian and covers something that I was considering when I first started blogging. Science news and articles are becoming increasingly popular, but with so much being written about so many things, it can be confusing for the beginner science enthusiast to grasp what they’re reading and how to interpret it. ...

Have a more powerful tool and you see more

Dula AN, Pawate S, Dortch RD, Barry RL, George-Durrett KM, Lyttle BD, Dethrage LM, Gore JC, Smith SA. Magnetic resonance imaging of the cervical spinal cord in multiple sclerosis at 7T. Mult Scler. 2015. pii: 1352458515591070. [Epub ahead of print] BACKGROUND: The clinical course of multiple sclerosis (MS) is mainly attributable to cervical and upper thoracic spinal cord dysfunction. High...

The Blog will now evolve

Thank you we will now allow the blog to continue to evolve? #MSBlog #MSResearch “The response and results of yesterday’s survey on the evolution of the blog was very clear. More importantly the discussion was very useful. Apologies about getting byline and strapline confused. In fact both the byline and strapline refer to individual articles. Based on the comments and results of the...

What’s in a Name

Dear All Thank you for voting for the Survey…What’s in a name.  If you haven’t done it sign up to MS Register in the UK, and  NARCOMS in North America.                                                         I will post...

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