ArchiveAugust 2015

ClinicSpeak: does time matter?

What will it take for us to treat MS more actively? More wheelchairs? #MSBlog #MSResearch #ClinicSpeak “Does the aphorism ‘Time is Brain’ apply to MS? Yes, I think it does. When we were attempting to get alemtuzumab licensed as a firstline treatment in Europe, I used the following two case studies to illustrate what the potential price is of delaying access to a highly-active...

Killing CD20 T cells

Holley JE, Bremer E, Kendall AC, de Bruyn M, Helfrich W, Tarr JM, Newcombe J, Gutowski NJ, Eggleton P. CD20+inflammatory T-cells are present in blood and brain of multiple sclerosis patients and can be selectively targeted for apoptotic elimination. Mult Scler Relat Disord. 2014;3(5):650-8. BACKGROUND: A subset of T-cells expresses the B-cell marker CD20 and in rheumatoid arthritis...

Speed makes processing faster.

Morrow SA, Rosehart H. Effects of single dose mixed amphetamine salts – extended release on processing speed in multiple sclerosis: a double blind placebo controlled study.Psychopharmacology (Berl). 2015 Aug. [Epub ahead of print] RATIONALE:Multiple sclerosis (MS) commonly affects cognitive function, most frequently presenting as impaired processing speed (PS). There are currently no...

NeuroSpeak: reversible cerebral vasoconstriction syndrome and fingolimod

Another possible vascular complication of fingolimod; reversible cerebral vasoconstriction syndrome #NeuroSpeak #MSBlog “Reversible cerebral vasoconstriction syndrome (RCVS) is a relatively new condition. I have my first patient admitted under me a few months ago with this condition. She presented with a thunderclap headache whilst running on a treadmill and was admitted with a subarachnoid...

Are you being sold a curve ball when trying to explain your genes

Explaining, not just predicting, drives interest in personal genomics. Meisel SF, Carere DA, Wardle J, Kalia SS, Moreno TA, Mountain JL, Roberts JS, Green RC; PGen Study Group. Genome Med. 2015;7(1):74. doi: 10.1186/s13073-015-0188-5. eCollection 2015. BACKGROUND: There is a widespread assumption that risk prediction is the major driver of customer interest in personal genomic testing...

Genes and response to interferons

Bertoli D, Serana F, Sottini A, Cordioli C, Maimone D, Amato MP, Centonze D, Florio C, Puma E, Capra R, Imberti L.Less Frequent and Less Severe Flu-Like Syndrome in Interferon Beta-1a Treated Multiple Sclerosis Patients with at Least One Allele Bearing the G&C Polymorphism at Position -174 of the IL-6 Promoter Gene.PLoS One. 2015;10(8):e0135441 One of the most common adverse event of...

ResearchSpeak: could cognitive fatigue be linked to specific neuronal pathways?

Have we found the brain’s fatigue pathway? #ResearchSpeak #MSBlog #MSResearch  “I have been very interested in the neural substrate that underpins fatigue in people in general and in people with MS. Unlike other symptoms there is not a specific area of the brain where the percept of fatigue lies. What I mean is that unlike other sensory percepts (a conscious awareness of...

Now you see and now you don’t – Neurofilament predicts visual outcome

Mult Scler. 2015 Aug 17. pii: 1352458515599074. [Epub ahead of print] Cerebrospinal fluid neurofilament light chain levels predict visual outcome after optic neuritis. Modvig S, Degn M, Sander B, Horwitz H, Wanscher B, Sellebjerg F, Frederiksen JL Abstract BACKGROUND: Optic neuritis is a good model for multiple sclerosis relapse, but currently no tests can accurately predict visual outcome...

Nerves affecting colour vision

Lampert EJ, Andorra M, Torres-Torres R, Ortiz-Pérez S, Llufriu S, Sepúlveda M, Sola N, Saiz A, Sánchez-Dalmau B, Villoslada P, Martínez-Lapiscina EH. Color vision impairment in multiple sclerosis points to retinal ganglion cell damage. J Neurol. 2015 Aug. [Epub ahead of print] Multiple Sclerosis (MS) results in color vision impairment regardless of optic neuritis (ON). The exact...

Competition to redesign MS Journal cover

The Journal “Multiple Sclerosis and Related Disorders” (MSARD) is inviting artists and designers to improve its front cover with the winning design receiving a prize of £500. This is what the journal cover currently looks like…. The journal editors are accepting submissions of original artworks or designs for the front cover that are inspired or reference multiple sclerosis or a related...

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