ArchiveSeptember 2015

Calling all Neurologists…Please Read.

A BBC report says A brain specialist who advises the National Institute of Health and Care Excellence (NICE) says although disease-modifying drugs have a role in established relapsing, remitting disease, there is still debate about their use early on in the condition. Please Read Is the MS Community Prepared to Promote Brain Health? With comments like the above……you have your work cut...

ResearchSpeak: B cells in the spotlight

How long will the B cell remain top of the pops? I am a plasma cell fan. #MSBlog #MSResearch #ResearchSpeak “The B cell is now firmly in the MS spotlight and will be even more so after we get to hear the ocrelizumab results at ECTRIMS. When proposing a cause of MS we have to be able to explain the effect of all the DMTs on the causal pathway. When I did...

Sex hormones and glucose

Triantafyllou N, Thoda P, Armeni E, Rizos D, Kaparos G, Augoulea A, Alexandrou A, Creatsa M, Tsivgoulis G, Artemiades A, Panoulis C, Lambrinoudaki I.Association of sex hormones and glucose metabolism with the severity of multiple sclerosis. Int J Neurosci. 2015:1-8. [Epub ahead of print] Purpose/Aim of the study: We evaluated possible associations between the severity of multiple sclerosis...

Potassium Channel Opener bombs in MS

Villoslada P, Rovira A, Montalban X, Arroyo R, Paul F, Meca-Lallana V, Ramo C, Fernandez O, Saiz A, Garcia-Merino A, Ramió-Torrentà L, Casanova B, Oreja-Guevara C, Muñoz D, Martinez-Rodriguez JE, Lensch E, Prieto JM, Meuth SG, Nuñez X, Campás C, Pugliese M; NeuroAdvan study. Effects of diazoxide in multiple sclerosis: A randomized, double-blind phase 2 clinical trial. Neurol...

ClinicSpeak: managing expectations

What are you expecting ocrelizumab to do for your PPMS? #ClinicSpeak #MSBlog #MSResearch “In the past I have always warned that we should not expect too much from the first effective DMTs in progressive MS. They are unlikely to be miracle drugs. I therefore would like to prepare you for the ocrelizumab results when they are presented. In other words I want to set realistic expectations...

The History of B cell depletion in PPMS

Hawker K, O’Connor P, Freedman MS, Calabresi PA, Antel J, Simon J, Hauser S, Waubant E, Vollmer T, Panitch H, Zhang J, Chin P,Smith CH; OLYMPUS trial group.Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial.Ann Neurol. 2009;66(4):460-71. OBJECTIVE: Rituximab, a monoclonal antibody selectively...

It’s all the RAGE measuring progression

Sternberg Z, Chiotti A, Tario J, Chichelli T, Patel N, Chadha K, Yu J, Karmon Y. Reduced expression of membrane-bound (m)RAGE is a biomarker of multiple sclerosis disease progression.  Immunobiology. 2015. pii: S0171-2985(15)30060-7. OBJECTIVES: This study is one in series measuring RAGE axis (receptor for advanced glycation end products, its isoforms, and ligands) as a biomarker in multiple...

Ocrelizumab Results

You said

Dear B cells,
I want to end our relationship.
It’s not you its me, I feel that you participate in an attack against me for no good reason. We’ve had a long time together but I think that you need to leave.
-Aidan

NewsSpeak: finally some good news for PPMSers

Finally a positive trial for PPMS. #NewsSpeak #MSBlog #MSResearch “As far as news, and good news, goes this ECTRIMS is going to be the best ever. As you can see from the Roche press release below the phase 3 study of ocrelizumab (anti-CD20) in PPMS is positive. Yes, ocrelizumab slows the acquisition of disability in PPMSers.” “What more can I say? Except, I would like to thank...

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