ArchiveSeptember 2015

Calling all Neurologists…Please Read.

A BBC report says A brain specialist who advises the National Institute of Health and Care Excellence (NICE) says although disease-modifying drugs have a role in established relapsing, remitting disease, there is still debate about their use early on in the condition. Please Read Is the MS Community Prepared to Promote Brain Health? With comments like the above……you have your work cut...

Sex hormones and glucose

Triantafyllou N, Thoda P, Armeni E, Rizos D, Kaparos G, Augoulea A, Alexandrou A, Creatsa M, Tsivgoulis G, Artemiades A, Panoulis C, Lambrinoudaki I.Association of sex hormones and glucose metabolism with the severity of multiple sclerosis. Int J Neurosci. 2015:1-8. [Epub ahead of print] Purpose/Aim of the study: We evaluated possible associations between the severity of multiple sclerosis...

Potassium Channel Opener bombs in MS

Villoslada P, Rovira A, Montalban X, Arroyo R, Paul F, Meca-Lallana V, Ramo C, Fernandez O, Saiz A, Garcia-Merino A, Ramió-Torrentà L, Casanova B, Oreja-Guevara C, Muñoz D, Martinez-Rodriguez JE, Lensch E, Prieto JM, Meuth SG, Nuñez X, Campás C, Pugliese M; NeuroAdvan study. Effects of diazoxide in multiple sclerosis: A randomized, double-blind phase 2 clinical trial. Neurol...

The History of B cell depletion in PPMS

Hawker K, O’Connor P, Freedman MS, Calabresi PA, Antel J, Simon J, Hauser S, Waubant E, Vollmer T, Panitch H, Zhang J, Chin P,Smith CH; OLYMPUS trial group.Rituximab in patients with primary progressive multiple sclerosis: results of a randomized double-blind placebo-controlled multicenter trial.Ann Neurol. 2009;66(4):460-71. OBJECTIVE: Rituximab, a monoclonal antibody selectively...

It’s all the RAGE measuring progression

Sternberg Z, Chiotti A, Tario J, Chichelli T, Patel N, Chadha K, Yu J, Karmon Y. Reduced expression of membrane-bound (m)RAGE is a biomarker of multiple sclerosis disease progression.  Immunobiology. 2015. pii: S0171-2985(15)30060-7. OBJECTIVES: This study is one in series measuring RAGE axis (receptor for advanced glycation end products, its isoforms, and ligands) as a biomarker in multiple...

Ocrelizumab Results

You said

Dear B cells,
I want to end our relationship.
It’s not you its me, I feel that you participate in an attack against me for no good reason. We’ve had a long time together but I think that you need to leave.
-Aidan

Cannabinoids control symptoms and may limit nerve loss

#MSresearch Fantastic review of cannabis in MS Pryce G, Baker D. Endocannabinoids in Multiple Sclerosis and Amyotrophic Lateral Sclerosis. Handb Exp Pharmacol. 2015;231:213-231 There are numerous reports that people with multiple sclerosis (MS) have for many years been self-medicating with illegal street cannabis or more recently medicinal cannabis to alleviate the symptoms associated with MS and...

Docs blowing the whistle on Pharma. Oiling the pharma cogs, greasing the neuros pockets

#MS Research Oiling the pharma cogs, greasing the neuros pockets Doctors have been taking a self-inflicted bashing at the end of last week, so you may be interested to read this article whilst sticking the boot in. You may have noticed that ProfG has not been posting as often as he used to. Is it because he is adjusting his life-style or has he been knobbled by Pharma to stop posting negative...

Stem cells promoting repair

Glenn JD, Smith MD, Kirby LA, Baxi EG, Whartenby KA. Disparate Effects of Mesenchymal Stem Cells in Experimental Autoimmune Encephalomyelitis and Cuprizone-Induced Demyelination. PLoS One. 2015 Sep 25;10(9):e0139008. Mesenchymal stem cells (MSCs) are pleiotropic cells with potential therapeutic benefits for a wide range of diseases. Because of their immunomodulatory properties they have...

Factors affecting long term outcomes

Kappos L, Kuhle J, Multanen J, Kremenchutzky M, Verdun di Cantogno E, Cornelisse P, Lehr L, Casset-Semanaz F, Issard D, Uitdehaag BM. Factors influencing long-term outcomes in relapsing-remitting multiple sclerosis: PRISMS-15. J Neurol Neurosurg Psychiatry. 2015 Sep. pii: jnnp-2014-310024. An exploratory study of the relationship between cumulative exposure to subcutaneous (sc) interferon (IFN) β...

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