MS risk it is now in the size of your hand?

Bove R, Malik MT, Diaz-Cruz C, Chua A, Saraceno TJ, Bargiela D, Greeke E, Glanz BI, Healy BC, Chitnis T. The 2D:4D ratio, a proxy for prenatal androgen levels, differs in men with and without MS. Neurology. 2015. pii: 10.1212/WNL.0000000000001990. [Epub ahead of print]

OBJECTIVE:To determine whether the 2D:4D ratio (ratio of the second and fourth digit lengths), a proxy for lower prenatal androgen to estrogen ratio, differs in men with and without multiple sclerosis (MS) using a case-control study design.
METHODS:We obtained 2 digital scans of the right hand for men with MS presenting to a scheduled clinic visit at a large MS referral center, and for men without autoimmune or endocrine diseases. All individuals were aged 18 to 65 years, right-handed, and reported no prior digit trauma. We calculated a mean 2D:4D ratio using digital calipers. In participants with MS, we assessed age at first MS symptoms, MS type, and the MS Severity Score; 51 had provided a testosterone level within 10 years of symptom onset. Our primary analysis was a cross-sectional comparison of the 2D:4D ratio between men with and without MS, using a 2-sample t test for independent samples assuming unequal variance.
RESULTS:In total, we scanned 137 men with MS and 145 men without MS. A statistically significant association between 2D:4D ratio and MS status was observed in the univariate logistic regression model (p < 0.05). These differences were not associated with age or race, which differed between the 2 groups. In participants with MS, the 2D:4D ratio was not correlated with MS type, age at first symptoms, or MS Severity Score (p > 0.15 for each), and it was not correlated with adult testosterone levels (r = 0.06, p = 0.68, n = 51).
CONCLUSIONS: During the prenatal period, low androgens could represent a risk factor for MS.

A post doc that used to work with me thought that penis length related to size of your feet….her partner had size 12:-). So in this paper we had the ratio of the index ring to ring finger and find that the size differs from people without MS…….what next? Ear lobe size?

So will we see a raft of studies showing this works for other autoimmune diseases, which show male female differences.

Needless to say the penis size to body parts has not been substantiated.

A statistically significant correlation between penis size and the size of other body parts has not been found in research. One study, Siminoski and Bain (1993), found a weak correlation between the size of the stretched penis and foot size and height; however, it was too weak to be used as a practical estimator.Another investigation, Shah and Christopher (2002) failed to find any evidence for a link between shoe size and stretched penis size, stating “the supposed association of penile length and shoe size has no scientific basis.

Will the finger size fall on a sword too.

But if you think it is androgen levels why not measure them rather than some pop science?

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    • There is dermatoglyphics, which is the medical study of palms and fingerprints.

      Some genetic diseases can impact on the way the fetus develops. This can result in characteristic changes in palm prints.

      Viral diseases can leave traces in infants palms and fingerprints, such as german measles. In the case of some women who caught german measles in the early stages of pregnancy.


    • Found this article from 2014
      Dermatoglyphic features in patients with multiple sclerosis

      To examine dermatoglyphic features
      to clarify implicated genetic predisposition in the
      etiology of multiple sclerosis (MS)

      In both hands of the patients with MS, the a-b
      ridge count and ridge counts in all fingers increased,
      and the differences in these values were statistically
      significant. There was also a statistically significant
      increase in the dat angle in both hands of the MS
      patients. On the contrary, there was no statistically
      significant difference between the groups in terms of
      dermal ridge samples, and the most frequent sample
      in both groups was the ulnar loop.
      Aberrations in the distribution of dermatoglyphic samples support the genetic predisposition in MS etiology. Multiple sclerosis
      susceptible individuals may be determined by
      analyzing dermatoglyphic samples.

    • Yes, I'm sure there are many such studies, but this seems like peripheral, inconsequential science to me. I don't see how these studies are helpful in terms of actually helping people with MS. We know that MS has a strong genetic component already. Whether or not genes predisposing to MS appear to be statistically correlated with some random physiological feature doesn't seem like a hot area of urgent research to me.

    • It was just an example of something that we may disregard but actually is of some benefit. Granted it may not be a hot area of urgent research but research like this may uncover something useful to someone.
      The answers about MS may be right under our nose.

  • So – they just talk about ratios and don't actually state whether the index finger or ring finger is longer in their sample.
    I'm female, have late onset MS (looking progressive not RR), and on both of my hands the ring finger is longer than the index finger. What does this say, if anything, about me, as various hormone levels during gestation don't just affect males.

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