ArchiveOctober 2015

Myelin Autoimmunity is lacking

van Nierop GP, Janssen M, Mitterreiter JG, van de Vijver DA, de Swart RL, Haagmans BL, Verjans GM, Hintzen RQ. Intrathecal CD4+ and CD8+ T cell responses to endogenously synthesized candidate disease-associated human autoantigens in multiple sclerosis patients. Eur J Immunol. 2015 Oct 28. doi: 10.1002/eji.201545921. [Epub ahead of print] Multiple sclerosis (MS) pathology is potentially...

Bad B cells make GM-CSF

Li et al. Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy.Sci Transl Med. 2015 Oct 21;7:310ra166. Background: B cells are not limited to producing protective antibodies; they also perform additional functions relevant to both health and disease. However, the relative contribution of functionally distinct B cell subsets in human disease, the signals that...

There is autoimmunity in MS. B means Bad!

Blauth K, Soltys J, Matschulat A, Reiter CR, Ritchie A, Baird NL, Bennett JL, Owens GP. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid cause demyelination of spinal cord explants. Acta Neuropathol. 2015 Oct 28. [Epub ahead of print] B cells are implicated in the aetiology of multiple sclerosis (MS). Intrathecal IgG synthesis, cerebrospinal fluid...

Will Teva and Biogen Come together for the sake of DMF, laquinimod polypill

Hund AC, Lockmann A, Schön MP. Mutually enhancing anti-inflammatory activities of dimethyl fumarate and NF-κB inhibitors – Implications for dose-sparing combination therapies. Exp Dermatol. 2015 Oct 29. doi: 10.1111/exd.12892. [Epub ahead of print] Fumaric acid esters, dimethyl fumarate (DMF) in particular, have been established for the therapy of psoriasis and, more recently, multiple...

Take two – PoliticalSpeak: Off-patent Drugs Bill – 6th November

Here’s the email I sent Chuka Umunna on 18 Oct:  Dear Mr Umunna I am contacting you about the drug re-purposing Bill to ask for your support to see it become Law. I believe it comes before the house on November 6. I attach some documents setting out the case for the Bill and please excuse me if you are already familiar with the arguments. Breakthroughs in research have meant that...

PoliticalSpeak: Off-patent Drugs Bill – 6th November

Dear Chuka Umunna I am Professor of Neurology at Barts Health NHS Trust and have a sub-specialty interest in multiple sclerosis (MS). MS is the most common disabling disease to affect young adults in the UK. An estimated 120,000 people have MS in the UK. As it affects young people its socioeconomic impact is very large. There is a long list of drugs that may be effective in treating MS that are...

B cells assume control

Li R, Rezk A, Miyazaki Y, Hilgenberg E, Touil H, Shen P, Moore CS, Michel L, Althekair F, Rajasekharan S, Gommerman JL, Prat A, Fillatreau S, Bar-Or A; Canadian B cells in MS Team. Proinflammatory GM-CSF-producing B cells in multiple sclerosis and B cell depletion therapy.Sci Transl Med. 2015 Oct 21;7(310):310ra166. doi: 10.1126/scitranslmed.aab4176. B cells are not limited to producing...

Repurposing Bill

Time for Activity as the Repurposing Bill is soon to be given Prime time. . But still time to get your MP to do something useful Will it get a debate or will it be binned? Few Private members Bills make it and so be prepared for the worse…  We should expect,  Pharma lobbying of Government to keep the playing field level and with many MPsappearing to take Pharma Bungs, this is...

ClinicSpeak: is it time to ditch regular follow-up visits with your neurologist?

What is the value of regular visits  to your neurologist if you are well? #ClinicSpeak #MSBlog #MSResearch “How valuable are your 6-monthly, annual, or regular neurological appointments in MS? In the past I would have said very valuable as they allowed us, the neurological team, to interrogate you and identify MS-related problems early and manage them before they cause too many...

MD I don’t understand your graphics

Sometimes you are not supposed to…. yet However they make sense if you know what they are saying Picture of the left (below) used in                                Alternative Coat of Arms of the ABN? You asked “Do you write puzzles” for those of you who have been visiting the blog for some time, can...

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