I have to say this is what I predicted before it even started and importantly it is also what EAE predicted too.
An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss. Hampton DW, Anderson J, Pryce G, Irvine KA, Giovannoni G, Fawcett JW, Compston A, Franklin RJ, Baker D, Chandran S. J Neuroimmunol. 2008; 201-202:200-11.
Immunosuppression with FTY720 (Gilenya)is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis. Mult Scler. 2011; 17(8):939-48. doi:Hampton DW, Serio A, Pryce G, Al-Izki S, Franklin RJ, Giovannoni G, Baker D, Chandran S.Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis. Acta Neuropathol Commun. 2013 Dec 23;1:84
Other people have been beaten into submission like some sort of Stepford Wive so they follow the dogma.
However, we have been proved right again and again and again.
Do I think that inflammation that can respond to immunosuppressives in progressive MS. The answer is yes but we need something in addition. ProfG may also argue that we need to move away from lower limb mobility to.
There are a load ongoing and so prepare yourself for more disappointment.
Why do they keep doing this? I can only guess.
I went up to one company person doing a tolerance study in progressive MS at a meeting and said despite them conning themselves that there was a glimmer of hope in the phase II trial data, their phase III was going to fail.
It did and the company is no more.
However, because relapsing-remitting MS is being sewn up by pharma drugs, and unless you are a mega company who can pressurise the regulators to allow you to do a placebo control trial, you can’t afford to do a non inferiority against a current MS drug as you will have to buy it at $100,000+ (for 2 years) a person to buy the comparator drug.
So they go mirror, mirror on the wall, We believe that T cell immunotherapy will cure it all
This allows them to do a placebo control to save a buck, but in doing so they flush their assests down the toilet and their companies into liquidation.
There will be a few CEOs shedding their shares on this news because they will soon be printed on toilet paper.
Don’t blame EAE. Blame the humans.