ArchiveNovember 2015

Intravenous Tolerance study indicating autoimmunity in MS

van Noort JM, Bsibsi M, Nacken PJ, Verbeek R, Venneker EH.Therapeutic Intervention in Multiple Sclerosis with Alpha B-Crystallin: A Randomized Controlled Phase IIa Trial. PLoS One. 2015 Nov 23;10(11):e0143366. As a molecular chaperone and activator of Toll-like receptor 2-mediated protective responses by microglia and macrophages, the small heat shock protein alpha B-crystallin (HspB5)...

A way to silence Neuropathic Pain

Laumet G, Garriga J, Chen SR, Zhang Y, Li DP, Smith TM, Dong Y, Jelinek J, Cesaroni M, Issa JP, Pan HL.G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition.Nat Neurosci. 2015;18(12):1746-55. Neuropathic pain is a debilitating clinical problem and difficult to treat. Nerve injury causes a long-lasting reduction in K+ channel expression in the dorsal...

Cannabis for spasticity

Paolicelli D, Direnzo V, Manni A, D’Onghia M, Tortorella C, Zoccolella S, Lecce VD, Iaffaldano A, Trojano M. Long-Term Data of Efficacy, Safety and Tolerability in a Real Life Setting of THC/CBD Oromucosal Spray-Treated Multiple Sclerosis Patients.J Clin Pharmacol. 2015 Nov 26. doi: 10.1002/jcph.670. Delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray was approved as add...

Your Genes can protect you from MS

Bettencourt A, Carvalho C, Leal B, Brás S, Lopes D, Martins da Silva A, Santos E, Torres T, Almeida I, Farinha F, Barbosa P, Marinho A, Selores M, Correia J, Vasconcelos C, Costa PP, da Silva BM. The Protective Role of HLA-DRB1(∗)13 in Autoimmune Diseases.J Immunol Res. 2015;2015:948723. Autoimmune diseases (AIDs) are characterized by a multifactorial aetiology and a complex genetic background...

JCV virus infection at presentation of MS

Delbue S, Tadeo CS, Elia F, Ferrante P. Intervirology. JC Virus Replication at the First Symptoms of Multiple Sclerosis: A Case Report. 2015;58:278-282. Multiple sclerosis (MS) is an autoimmune, demyelinating disorder of unknown aetiology, in which viruses have been suggested as aetiological/triggering agents. The attention to the association between viruses and MS has been rekindled by...

Automated lesion detection

Fartaria MJ, Bonnier G, Roche A, Kober T, Meuli R, Rotzinger D, Frackowiak R, Schluep M, Du Pasquier R, Thiran JP, Krueger G, Bach Cuadra M, Granziera C. Automated detection of white matter and cortical lesions in early stages of multiple sclerosis. J Magn Reson Imaging. 2015. doi: 10.1002/jmri.25095. [Epub ahead of print]PURPOSE:To develop a method to automatically detect multiple sclerosis (MS)...

To correlate or not to correlate that is the question

Aboulenein-Djamshidian F, Krššák M, Serbecic N, Rauschka H, Beutelspacher S, Kukurová IJ, Valkovič L, Khan A, Prayer D, Kristoferitsch W. CROP – The Clinico-Radiologico-Ophthalmological Paradox in Multiple Sclerosis: Are Patterns of Retinal and MRI Changes Heterogeneous and Thus Not Predictable? PLoS One. 2015 Nov 13;10(11):e0142272. BACKGROUND:To date, no direct scientific evidence has...

Spasticity treatment that doesn’t cut the mustard

Rommer PS, Kamin F, Abu-Mugheisib M, Koehler W, Hoffmann F, Winkelmann A, Benecke R, Zettl UK. Long-Term Effects of Repeated Cycles of Intrathecal Triamcinolone Acetonide on Spasticity in MS Patients. CNS Neurosci Ther. 2015 doi: 10.1111/cns.12474. [Epub ahead of print] MAIN PROBLEM:Spasticity is a common feature in patients with multiple sclerosis (MS). Although options have broadened...

Season of Birth effects in Tunisia

Sidhom Y, Kacem I, Bayoudh L, Ben Djebara M, Hizem Y, Ben Abdelfettah S, Gargouri A, Gouider R.Season of birth and multiple sclerosis in Tunisia.Mult Scler Relat Disord. 2015 Nov;4(6):491-494. BACKGROUND:Recent studies on date of birth of multiple sclerosis (MS) patients showed an association between month of birth and the risk of developing MS. This association has not been investigated in an...

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