ArchiveNovember 2015

Junior doctors’ industrial action suspended

From: BMASent: 30 November 2015 19:27To: g.giovannoni Subject: Junior doctors’ industrial action suspended Dear Dr Giovannoni, Following conciliatory talks with NHS Employers and the Department of Health, we have agreed to suspend industrial action in England, which was due to begin at 8am tomorrow. The Government has also agreed not to proceed unilaterally with the introduction of a new...

Intravenous Tolerance study indicating autoimmunity in MS

van Noort JM, Bsibsi M, Nacken PJ, Verbeek R, Venneker EH.Therapeutic Intervention in Multiple Sclerosis with Alpha B-Crystallin: A Randomized Controlled Phase IIa Trial. PLoS One. 2015 Nov 23;10(11):e0143366. As a molecular chaperone and activator of Toll-like receptor 2-mediated protective responses by microglia and macrophages, the small heat shock protein alpha B-crystallin (HspB5)...

PoliticalSpeak: preventable adverse events with off-label prescribing

Off-label use of drugs are associated with higher rates of preventable adverse drug events. #PoliticalSpeak #MSBlof #MSResearch #OffLabel “Various academics within our University are strongly against our position of promoting off-label prescribing of DMTs to pwMS in resource-poor settings; the most outspoken person being Professor Allyson Pollock. If any of you have met Allyson, and debated...

ClinicSpeak: MRI monitoring for PML is simply not good enough yet

Are you having regular MRI PML monitoring scans? #ClinicSpeak #MSBlog #MSResearch “Earlier this week a colleague of mine was discussing the junior doctors’ industrial action and how we must support them; which I do. The discussion got down to how at the core of the new junior contract is simply the downward income spiral facing doctors. My colleague mentioned that this is part of a...

Cannabis for spasticity

Paolicelli D, Direnzo V, Manni A, D’Onghia M, Tortorella C, Zoccolella S, Lecce VD, Iaffaldano A, Trojano M. Long-Term Data of Efficacy, Safety and Tolerability in a Real Life Setting of THC/CBD Oromucosal Spray-Treated Multiple Sclerosis Patients.J Clin Pharmacol. 2015 Nov 26. doi: 10.1002/jcph.670. Delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray was approved as add...

A way to silence Neuropathic Pain

Laumet G, Garriga J, Chen SR, Zhang Y, Li DP, Smith TM, Dong Y, Jelinek J, Cesaroni M, Issa JP, Pan HL.G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition.Nat Neurosci. 2015;18(12):1746-55. Neuropathic pain is a debilitating clinical problem and difficult to treat. Nerve injury causes a long-lasting reduction in K+ channel expression in the dorsal...

PoliticalSpeak: are you an early adopter?

Please adopt our policy and pledge your support. #PoliticalSpeak #BrainHealth #MSBlog “I have just got back from the 23rd European Charcot Meeting, in Baveno, Italy. I was invited to present our ‘Brain Health – Time matters in MS’ policy document. My presentation was a bit rushed as I was expecting to have 30 minutes, but was told to cut it down to 15 minutes just before I presented. As promised...

Your Genes can protect you from MS

Bettencourt A, Carvalho C, Leal B, Brás S, Lopes D, Martins da Silva A, Santos E, Torres T, Almeida I, Farinha F, Barbosa P, Marinho A, Selores M, Correia J, Vasconcelos C, Costa PP, da Silva BM. The Protective Role of HLA-DRB1(∗)13 in Autoimmune Diseases.J Immunol Res. 2015;2015:948723. Autoimmune diseases (AIDs) are characterized by a multifactorial aetiology and a complex genetic background...

JCV virus infection at presentation of MS

Delbue S, Tadeo CS, Elia F, Ferrante P. Intervirology. JC Virus Replication at the First Symptoms of Multiple Sclerosis: A Case Report. 2015;58:278-282. Multiple sclerosis (MS) is an autoimmune, demyelinating disorder of unknown aetiology, in which viruses have been suggested as aetiological/triggering agents. The attention to the association between viruses and MS has been rekindled by...

ClinicSpeak: who writes your blog posts for you?

Why are people suspicious of something that is free? #MSBlog #ClinicSpeak “Yesterday on our Barts-MS Preceptorship one of the attendees asked me if (1) I write all my own blog posts and (2) if the blog really costs nothing. The answers to both these questions is yes.” “The abstract triage system is run by the Mouse Doctor. He identifies most of the articles for the blog. The articles he...

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