ArchiveNovember 2015

Automated lesion detection

Fartaria MJ, Bonnier G, Roche A, Kober T, Meuli R, Rotzinger D, Frackowiak R, Schluep M, Du Pasquier R, Thiran JP, Krueger G, Bach Cuadra M, Granziera C. Automated detection of white matter and cortical lesions in early stages of multiple sclerosis. J Magn Reson Imaging. 2015. doi: 10.1002/jmri.25095. [Epub ahead of print]PURPOSE:To develop a method to automatically detect multiple sclerosis (MS)...

To correlate or not to correlate that is the question

Aboulenein-Djamshidian F, Krššák M, Serbecic N, Rauschka H, Beutelspacher S, Kukurová IJ, Valkovič L, Khan A, Prayer D, Kristoferitsch W. CROP – The Clinico-Radiologico-Ophthalmological Paradox in Multiple Sclerosis: Are Patterns of Retinal and MRI Changes Heterogeneous and Thus Not Predictable? PLoS One. 2015 Nov 13;10(11):e0142272. BACKGROUND:To date, no direct scientific evidence has...

ClinicSpeak: Is it your right to die with dignity?

Passive or active euthanasia; what is the difference? #ClinicSpeak #MSBlog #MSResearch “We have debated end-of-life care and advanced directives on our blog posts many times before. The consensus has been that PwMS choice is what is important in driving key decisions around end-of-life issues. I believe strongly in the holistic management of MS and to do this properly we need...

ResearchSpeak: brain volume loss and disability progression

Do you want to know if you are losing brain volume? #BrainHealth #ResearchSpeak #MSBlog #MSResearch “I am a big proponent of brain atrophy, or brain volume loss, as an integrator of end-organ damage in MS. Brain volume loss occurs in MS at a rate of between 2-7x the normal rate. Brain volume loss is linked to previous inflammatory activity and is a poor prognostic variable. In other words...

Spasticity treatment that doesn’t cut the mustard

Rommer PS, Kamin F, Abu-Mugheisib M, Koehler W, Hoffmann F, Winkelmann A, Benecke R, Zettl UK. Long-Term Effects of Repeated Cycles of Intrathecal Triamcinolone Acetonide on Spasticity in MS Patients. CNS Neurosci Ther. 2015 doi: 10.1111/cns.12474. [Epub ahead of print] MAIN PROBLEM:Spasticity is a common feature in patients with multiple sclerosis (MS). Although options have broadened...

Season of Birth effects in Tunisia

Sidhom Y, Kacem I, Bayoudh L, Ben Djebara M, Hizem Y, Ben Abdelfettah S, Gargouri A, Gouider R.Season of birth and multiple sclerosis in Tunisia.Mult Scler Relat Disord. 2015 Nov;4(6):491-494. BACKGROUND:Recent studies on date of birth of multiple sclerosis (MS) patients showed an association between month of birth and the risk of developing MS. This association has not been investigated in an...

A pinch more salt in macrophages

Hucke S, Eschborn M, Liebmann M, Herold M, Freise N, Engbers A, Ehling P, Meuth SG, Roth J, Kuhlmann T, Wiendl H, Klotz L. Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity. J Autoimmun. 2015. pii: S0896-8411(15)30052-4. The increasing incidence in Multiple Sclerosis (MS) during the last decades in industrialized countries might be linked to a...

ClinicSpeak: are you following medical advice?

How big a problem is DMT adherence in MS? #ClinicSpeak #MSBlog #MSResearch “On one of our recent MS preceptorships (teaching courses) one of the attendees challenged me about a statement I made that MSers on DMTs were more likely to be adherent to treatment than people with other chronic diseases. He asked what is the evidence? When I looked into this I found a rich literature that MSers...

Synaptic pathology – is it important in MS?

NATURE REVIEWS NEUROLOGY | REVIEW Synaptopathy connects inflammation and neurodegeneration in multiple sclerosis Georgia Mandolesi, Antonietta Gentile, Alessandra Musella, Diego Fresegna, Francesca De Vito, Silvia Bullitta, Helena Sepman, Girolama A. Marfia & Diego Centonze Neurology   (2015)   doi:10.1038/nrneurol.2015.222 Abstract Multiple sclerosis (MS) has long...

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