ArchiveJanuary 2016

Access to Medical Treatments (Innovation) Bill

Access to Medical Treatments (Innovation) Bill Is this the answer. Bill 8 56/1 Access to Medical Treatments (Innovation) Bill CONTENTS Introductory  1 Access to innovative medical treatments Database of innovative medical treatments  2 Database of innovative treatments Responsible innovation  3 Responsible innovation  4 Effect on existing law Interpretation  5...

Remyelinating

Dehghan S, Hesaraki M, Soleimani M, Mirnajafi-Zadeh J, Fathollahi Y, Javan M. Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice. Neuroscience. 2016 . pii: S0306-4522(16)00047-6. Multiple sclerosis is a demyelinating disease with severe neurological symptoms due to blockage of signal conduction in affected axons. Spontaneous...

Oxygen to the rescue

Desai RA, Davies AL, Tachrount M, Kasti M, Laulund F, Golay X, Smith KJ.Cause and prevention of demyelination in a model multiple sclerosis lesion.Anals Neurol. 2016 Jan 27. doi: 10.1002/ana.24607. [Epub ahead of print] BACKGROUND: Demyelination is a cardinal feature of multiple sclerosis, but it remains unclear why new lesions form, and whether they can be prevented. Neuropathological evidence...

Maybe the Government Does Listen And Take Note

The Repurposing bill ran into problems because the Government did not believe it was necessary. They feel it was not for the government to hold the licence but at the same time being the purchaser and more important they did not believe it was necessary as the Government were insistent that Doctors have the right to prescribe off-label. We have seen documents by George Freeman that clearly...

Is fludarabine the next hope to knock cladribine off its perch

Greenberg SJ et al.Fludarabine add-on therapy in interferon-beta-treated patients with multiple sclerosis experiencing breakthrough disease. Therapeutic Advances in Neurological Disorders January 21, 20161756285615626049 Background: Patients with relapsing–remitting multiple sclerosis (RRMS) may experience breakthrough disease despite effective interferon beta (IFNβ) therapy. Fludarabine...

Do you have Emotional Incontinence

Hanna J, Feinstein A, Morrow SA.The association of pathological laughing and crying and cognitive impairment in multiple sclerosis.J Neurol Sci. 2016 Feb 15;361:200-3. BACKGROUND:Pathological laughing and crying (PLC) is common in multiple sclerosis (MS), defined as emotional expression that is exaggerated/incongruent with underlying mood. In other neurological disorders, PLC is associated with...

MS Life 2016

This year ECTRIMS 2016 is in London, United Kingdom Perhaps 8,000-9,000 Neuros, Nurses, pharma bods will come  and perhaps be sad that the venue is nowhere near Buckingham Palace It will be the East-End of London, near to City Airport in the Docklands at the ExCel Centre But as soon as the Neuros move out, you can move-in.  MS Life 2016 , the flagship MS Society meeting for pwMS...

Dopamine modulation – a novel target for MS

Mol Neurobiol. 2016 Jan 22. [Epub ahead of print] Pramipexole, a Dopamine D2/D3 Receptor-Preferring Agonist, Prevents Experimental Autoimmune Encephalomyelitis Development in Mice. Lieberknecht V, Junqueira SC, Cunha MP, Barbosa TA, de Souza LF, Coelho IS, Santos AR, Rodrigues AL, Dafré AL, Dutra RC. Abstract Experimental autoimmune encephalomyelitis (EAE) is the most used animal model of...

New MRI technique for an early diagnosis of MS

Clinical 3-tesla FLAIR* MRI improves diagnostic accuracy in multiple sclerosis. George IC, Sati P, Absinta M, Cortese IC, Sweeney EM, Shea CD, Reich DS. Mult Scler. 2016 Jan 14. pii: 1352458515624975. [Epub ahead of print] OBJECTIVE: To evaluate clinical fluid-attenuated inversion recovery (FLAIR)* 3T magnetic resonance imaging (MRI), which is sensitive to perivenular inflammatory...

Antibody response to EBV associated with lesion burden

Humoral response to EBV is associated with cortical atrophy and lesion burden in patients with MS. Zivadinov R, Cerza N, Hagemeier J, Carl E, Badgett D, Ramasamy DP, Weinstock-Guttman B, Ramanathan M.Neurol Neuroimmunol Neuroinflamm. 2016 Jan 7;3(1):e190. doi: 10.1212/NXI.0000000000000190. eCollection 2016 Feb. OBJECTIVE:Because dysregulated Epstein-Barr virus (EBV)-infected B cells may...

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