ArchiveJanuary 2016

Access to Medical Treatments (Innovation) Bill

Access to Medical Treatments (Innovation) Bill Is this the answer. Bill 8 56/1 Access to Medical Treatments (Innovation) Bill CONTENTS Introductory  1 Access to innovative medical treatments Database of innovative medical treatments  2 Database of innovative treatments Responsible innovation  3 Responsible innovation  4 Effect on existing law Interpretation  5...

Remyelinating

Dehghan S, Hesaraki M, Soleimani M, Mirnajafi-Zadeh J, Fathollahi Y, Javan M. Oct4 transcription factor in conjunction with valproic acid accelerates myelin repair in demyelinated optic chiasm in mice. Neuroscience. 2016 . pii: S0306-4522(16)00047-6. Multiple sclerosis is a demyelinating disease with severe neurological symptoms due to blockage of signal conduction in affected axons. Spontaneous...

ClinicSpeak: switching from an injectable to an oral DMT

The power of data; moving mountains and liberating people with MS. #ClinicSpeak #MSBlog #MSResearch “Better the devil you know that the devil you don’t. I have been telling my patients who are stable on an injectable that as they are responding to a particular class of DMT do they really want to take a chance and switch  to an oral a new class of DMT when we have no idea if they...

Oxygen to the rescue

Desai RA, Davies AL, Tachrount M, Kasti M, Laulund F, Golay X, Smith KJ.Cause and prevention of demyelination in a model multiple sclerosis lesion.Anals Neurol. 2016 Jan 27. doi: 10.1002/ana.24607. [Epub ahead of print] BACKGROUND: Demyelination is a cardinal feature of multiple sclerosis, but it remains unclear why new lesions form, and whether they can be prevented. Neuropathological evidence...

Maybe the Government Does Listen And Take Note

The Repurposing bill ran into problems because the Government did not believe it was necessary. They feel it was not for the government to hold the licence but at the same time being the purchaser and more important they did not believe it was necessary as the Government were insistent that Doctors have the right to prescribe off-label. We have seen documents by George Freeman that clearly...

ResearchSpeak: daclizumab and black hole formation

Do you want to prevent end-organ damage or loss of brain tissue? #ResearchSpeak #MSBlog #MSResearch “Preventing end-organ damage is the what we should all be aiming for as a treatment target in MS. The end-organ is the brain and spinal cord. We know that MS, or the shredder, damages the end-organ acutely in MS lesions by transecting axons and killing nerves (relapse). Those axons and nerves...

Is fludarabine the next hope to knock cladribine off its perch

Greenberg SJ et al.Fludarabine add-on therapy in interferon-beta-treated patients with multiple sclerosis experiencing breakthrough disease. Therapeutic Advances in Neurological Disorders January 21, 20161756285615626049 Background: Patients with relapsing–remitting multiple sclerosis (RRMS) may experience breakthrough disease despite effective interferon beta (IFNβ) therapy. Fludarabine...

ResearchSpeak: what are the implications of the negative fingolimod PPMS trial

What can we learn from the negative fingolimod in PPMS trial? #MSBlog #MSResearch #ResearchSpeak “The INFORMS, or fingolimod in PPMS, study results have just been published online. We have discussed this study before in great detail. The fact this study was negative and fingolimod did not have an impact on any of the composite endpoints including upper limb function, nor an impact on brain...

ClinicSpeak & BrainHealth: solifenacin trial shows positive influence on bladder function

Are you on a centrally acting anticholinergic? If yes, you may want to consider stopping it. #ClinicSpeak #BrainHealth #MSBlog #MSResearch “The study below shows that the drug solifenacin (Vesicare), a so called anti-cholinergic drug of the antimuscarinic class, is effective in reducing contractions of overactive bladders and increasing bladder volume. This results in reduced urinary...

Do you have Emotional Incontinence

Hanna J, Feinstein A, Morrow SA.The association of pathological laughing and crying and cognitive impairment in multiple sclerosis.J Neurol Sci. 2016 Feb 15;361:200-3. BACKGROUND:Pathological laughing and crying (PLC) is common in multiple sclerosis (MS), defined as emotional expression that is exaggerated/incongruent with underlying mood. In other neurological disorders, PLC is associated with...

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