“Today is day 14 of our Crowdfunding initiative to establish the rate of EBV viral shedding in a population of pwMS. We are fortunate that frequent saliva samples were collected as part of an exercise study in Sheffield. This means that we can find out what we need to know regarding EBV viral shedding in pwMS without having to spend additional time, effort and money to set-up the collection part of this study. In short we are leap-frogging ahead by using an existing biobank of samples. We already have ethics approval and are ready to go. The rules of Crowdacure are that we can’t start our study until we have reached our target and if we don’t reach our target within the allocated collection time the money will be returned to the donors. Crowdfunding is all or nothing so please help us get to our target; even a £1 donation from enough of you will make a difference.”
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Coarelli et al. Characterization of Epstein–Barr virus genotypes in multiple sclerosis through next generation sequencing approaches. L Neuroimmunol 2014;08:209
Notwithstanding the highly converging evidence, the identification of the mechanisms responsible for the multiple sclerosis (MS)–Epstein–Barr virus (EBV) association remains difficult to clarify. The possibility that only a particular viral genotype associates with the disease is plausible and has been investigated by other groups, with conflicting results. We sequenced the most polymorphic region of the Epstein–Barr nuclear antigen 2 (EBNA2) in blood samples of MS patients and healthy donors (HD) and found an association between EBNA2 genetic variants and MS and a higher than expected breadth of new variants.