ArchiveJanuary 2016

Hand movement as a marker of disability

Ghandi Dezfuli M, Akbarfahimi M, Nabavi SM, Hassani Mehraban A, Jafarzadehpur E. Can hand dexterity predict the disability status of patients with multiple sclerosis? Med J Islam Repub Iran. 2015 Aug 30;29:255. eCollection 2015. BACKGROUND:Multiple Sclerosis (MS) is the most common disabling neurological disease. Hand dysfunction is one of the main complaints of patients with MS. The...

Research Day 2016

You asked will there be a research Day in 2016? This year the Research Day is being organized by Neuros from the Royal Free Hospital in UCL. They have booked Church House in London for June. I am not sure of the planned date….. It was mentioned last week and Sir Jeremy said it was the Queen’s Birthday (maybe he is after a real knighthood), which would put it on June 11th (this is not...

Plasma cells driving inflammation

Chen D, Ireland SJ, Davis LS, Kong X, Stowe AM, Wang Y, White WI, Herbst R, Monson NL.Autoreactive CD19+CD20- Plasma Cells Contribute to Disease Severity of Experimental Autoimmune Encephalomyelitis.Chen D, Ireland SJ, Davis LS, Kong X, Stowe AM, Wang Y, White WI, Herbst R, Monson NL.J Immunol. 2016. pii: 1501376. [Epub ahead of print] The contribution of autoantibody-producing plasma cells in...

Statistics

There are lies dam lies and statistics. Statistics are used to give an indication of the likelihood (probability) of finding a particular result by chance. The smaller the P value p=0.01 is a 1 in 100 chance and P=0.001 is a one in a thousand chance. We know that people doing basic science and publishing in Nature journal on experiments relating to MS have a problem grasping statistics as they...

What is Autologous Heamatopeitic Stem Cell Therapy

There is a lot of interest in AHSCT because  of the panorama programme this week but what is it. You will have heard of it on the TV programme but you will not have been told what it involves.  The problem is this means many different things and many ways to do this are used, which makes it difficult when you are trying to assess risk verses benefit.  There are two main types (a)...

The real life experience with fampridine

Jara M, Aquilina T, Aupperle P, Rabinowicz AL.Safety profile of dalfampridine extended release in multiple sclerosis: 5-year postmarketing experience in the United States.Drug Healthc Patient Saf. 2015 Dec 15;7:169-74BACKGROUND:Dalfampridine extended release tablets (dalfampridine-ER; prolonged-, modified, or sustained-release fampridine outside the US), 10 mg twice daily, was approved by the US...

Glaterimer acetate during pregnacy

Herbstritt S, Langer-Gould A, Rockhoff M, Haghikia A, Queisser-Wahrendorf A, Gold R, Hellwig K.Glatiramer acetate during early pregnancy: A prospective cohort study. Mult Scler. 2016 Jan 11. pii: 1352458515623366. [Epub ahead of print] BACKGROUND:Only limited data are available on whether glatiramer acetate exposure during pregnancy has an effect on perinatal outcome. OBJECTIVE:To determine...

Public Engagement 2015 year review

We are always open for new ideas on events, formats and topics to engage with, please let us know if you have any ideas. 

If you would like to get involved in some of our public engagement work, we still have places on this weekends Digesting Science event for children aged 6-12 years old and also places in the DMT adherence focus group.

Be NICE to me Sativex

Gras A, Broughton J.Cost-effectiveness model for the use of a cannabis-derived oromucosal spray for the treatment of spasticity in multiple sclerosis.Expert Rev Pharmacoecon Outcomes Res. 2016 Jan 9. [Epub ahead of print] BACKGROUND:Severity of spasticity in multiple sclerosis (MS) directly correlates with the level and cost of care required. This study assessed whether a...

Guest Post: Basil Sharrack and John Snowden

    Basil Sharrack (Neurologist) and John Snowden (Haematologist) Haematopoietic stem cell transplantation (HSCT) has been used as treatment for MS since the mid-nineties. The aim of this treatment is to reboot the immune system using chemotherapy which destroys the defective immune cells driving the inflammation in the brain and spinal cord and rebuilds a regenerated immune system from...

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