ArchiveFebruary 2016

Imaging myelination

Dynamic imaging of individual remyelination profiles in multiple sclerosis.Bodini B, Veronese M, García-Lorenzo D, Battaglini M, Poirion E, Chardain A, Freeman L, Louapre C, Tchikviladze M, Papeix C, Dollé F, Zalc B, Lubetzki C, Bottlaender M, Turkheimer F, Stankoff B. Anals Neurol. 2016. doi: 10.1002/ana.24620. [Epub ahead of print] BACKGROUND: Quantitative in vivo imaging of myelin...

PoliticalSpeak & OffLabel: high-cost drugs in the US

Will the war on high-cost drug pricing stifle innovation? #PoliticalSpeak #MSBlog #OffLabel “We have had much debate on the issue of high-cost drugs on this blog and have discussed the pros and cons endlessly. We have also taken a stand on the issue of the unaffordability of high-cost DMTs for pwMS living in resource-poor healthcare environments and have actively promoted off-label...

Cannabis Discontinuation

Fernández Ó.THC:CBD in Daily Practice: Available Data from UK, Germany and Spain Eur Neurol. 2016;75 Suppl 1:1-3. BACKGROUND:From the time Sativex (THC:CBD) oromucosal spray first became available in European Union countries in 2010 for the management of treatment-resistant multiple sclerosis (MS) spasticity, data from daily practice have been collected through various projects.METHODS:A...

ClinicSpeak: migraine headaches and MS

Did you know if you have MS you have more than a 1 in 3 chance of being a migraineur? #ClinicSpeak #MSResearch #MSBlog “How many of you suffer from headache? Did you know that migraine headache is much commoner in pwMS than in the general population? Why? It now become evident that in migraine is much more common in people who have brain disease in general. It seems as if focal pathology...

Waning Interest in CCSVI

Medical Tourism for CCSVI Procedures in People with Multiple Sclerosis: An Observational Study.Metz LM, Greenfield J, Marrie RA, Jette N, Blevins G, Svenson LW, Alikhani K, Wall W, Dhaliwal R, Suchowersky O. Can J Neurol Sci. 2016 Feb 4:1-8. [Epub ahead of print] BACKGROUND:Many Canadians with multiple sclerosis (MS) have recently travelled internationally to have procedures for a putative...

PoliticalSpeak: Judicial review & further junior doctor industrial action

Dear Dr Giovannoni, Last Saturday, the BMA junior doctors committee met to discuss the decision by the secretary of state to impose a contract on junior doctors in England from August 2016. The resounding message from that meeting is that junior doctors cannot and will not accept this new contract. As the government’s own former patient safety adviser, Prof Don Berwick, pointed out:...

ResearchSpeak & NeuroSpeak: JC viral escape post-natalizumab

How cunning is JCV or how foolish is our immune system? #ResearchSpeak #NeuroSpeak #MSBlog #MSResearch “Nothing in immunology is simple. The dogma in the immunology world is that CD8+ cytotoxic T-lymphocytes (CTLs) are all that is needed to clear the brains of pwMS of JC virus when they have PML. The study below suggests that the CTL response is not enough and that you also need CD4+ T...

MS in the USA

Dilokthornsakul P, Valuck RJ, Nair KV, Corboy JR, Allen RR, Campbell JD.Multiple sclerosis prevalence in the United States commercially insured population.Neurology. 2016 . pii: 10.1212/WNL.0000000000002469. [Epub ahead of print] OBJECTIVE:To estimate the US commercially insured multiple sclerosis (MS) annual prevalence from 2008 to 2012. METHODS:The study was a retrospective analysis using...

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