ArchiveMarch 2016

Biomarkers show that highly active DMT block inflammation and save nerves

Novakova L, Axelsson M, Khademi M, Zetterberg H, Blennow K, Malmeström C, Piehl F, Olsson T, Lycke J. Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis. Mult Scler. 2016. pii: 1352458516639384. [Epub ahead of print] BACKGROUND: The disease-modifying therapies (DMTs) in relapsing-remitting multiple sclerosis...

Meta analysis of the Week.

Zhang P, Wang R, Li Z, Wang Y, Gao C, Lv X, Song Y, Li B. The risk of smoking on multiple sclerosis: a meta-analysis based on 20,626 cases from case-control and cohort studies. PeerJ. 2016;4:e1797.  Background. Multiple sclerosis (MS) has become a disease that represents a tremendous burden on patients, families, and societies. The exact etiology of MS is still unclear, but it is believed...

The eye as a predictor of brain activity

Martinez-Lapiscina EH, Arnow S, Wilson JA, Saidha S, Preiningerova JL, Oberwahrenbrock T, Brandt AU, Pablo LE, Guerrieri S, Gonzalez I, Outteryck O, Mueller AK, Albrecht P, Chan W, Lukas S, Balk LJ, Fraser C, Frederiksen JL, Resto J, Frohman T, Cordano C, Zubizarreta I, Andorra M, Sanchez-Dalmau B, Saiz A, Bermel R, Klistorner A, Petzold A, Schippling S, Costello F, Aktas O, Vermersch P, Oreja...

To boldly go where no man/woman has gone before

Proc Natl Acad Sci U S A. 2016 Mar 14. pii: 201519286. [Epub ahead of print] Identification of tissue-specific cell death using methylation patterns of circulating DNA. Lehmann-Werman R, Neiman D, Zemmour H, Moss J, Magenheim J, Vaknin-Dembinsky A, Rubertsson S, Nellgård B, Blennow K, Zetterberg H, Spalding K, Haller MJ, Wasserfall CH, Schatz DA, Greenbaum CJ, Dorrell C, Grompe M, Zick A, Hubert...

Halting B cell Activation

Glatigny S, Wagner CA, Bettelli E. Cutting Edge: Integrin α4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis. J Immunol. 2016. pii: 1502614. [Epub ahead of print] The neutralization of integrin α4(Itga4) is currently used as treatment in multiple sclerosis. Although most studies have focused on its function on lymphocyte migration to the CNS, we have...

oligoclonal bands can be fouund if you look hard enough

Halbgebauer S, Huss A, Buttmann M, Steinacker P, Oeckl P, Brecht I, Weishaupt A, Tumani H, Otto M.Detection of intrathecal immunoglobulin G synthesis by capillary isoelectric focusing immunoassay in oligoclonal band negative multiple sclerosis.J Neurol. 2016 Mar 19. [Epub ahead of print] Oligoclonal immunoglobulin G bands (OCBs) restricted to the cerebrospinal fluid indicate intrathecal...

Cannabis inhibits Spasticity

Marinelli L, Mori L, Canneva S, Colombano F, Currà A, Fattapposta F, Bandini F, Capello E, Abbruzzese G, Trompetto C. The effect of cannabinoids on the stretch reflex in multiple sclerosis spasticity. Int Clin Psychopharmacol. 2016 Mar 21. [Epub ahead of print] The aim of this observational study was to assess the efficacy of a tetrahydrocannabinol-cannabidiol (THC : CBD) oromucosal spray on...

Will it be a Sprint to PPMS

It has been announced that the FDA will fast track the assessment of Ibudilast for the treatment of Progressive MS. At present a Phase II study in MS is ongoing “Safety, Tolerability and Activity Study of Ibudilast in Subjects With Progressive Multiple Sclerosis” (NCT01982942) Estimated completion = May 2107  It seems the trial is now recruited. This is a multicenter, randomized...

NSS–Vitamin D could be an issue. TeamG in the News

Last week TeamG was in the news….well to be Precise DrK and the students.  They had come to the conclusion that enviroment rather than genes were particularly important and within a generation, immigrants into the UK with black skin had acquired a high risk of MS such that MS was as common in black females as it was common in white males in East  London.  I knew it was...

Pathologist view of progression…what do they think…let’s sit on the fence.

Larochelle C, Uphaus T, Prat A, Zipp F. Secondary Progression in Multiple Sclerosis: Neuronal Exhaustion or Distinct Pathology? Trends Neurosci. 2016. pii: S0166-2236(16)00025-4 Prevention of progression in neurological diseases, particularly in multiple sclerosis (MS) but also in neurodegenerative diseases, remains a significant challenge. MS patients switch from a relapsing-remitting to a...

Translate

Categories

Recent Posts

Recent Comments

Archives