ArchiveMarch 2016

ClinicSpeak: do vaccines cause MS?

Are live vaccines a no-no for people with MS? #ClinicSpeak #MSBlog #MSResearch “Most people diagnosed with MS analyse their lives and look for ‘potential causes’ for their MS. It is not surprising that vaccinations get fingered as being the trigger, or cause, of MS in many people. The evidence suggests the contrary (see review below). MS is relatively common and vaccinations are...

Biomarkers show that highly active DMT block inflammation and save nerves

Novakova L, Axelsson M, Khademi M, Zetterberg H, Blennow K, Malmeström C, Piehl F, Olsson T, Lycke J. Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis. Mult Scler. 2016. pii: 1352458516639384. [Epub ahead of print] BACKGROUND: The disease-modifying therapies (DMTs) in relapsing-remitting multiple sclerosis...

ResearchSpeak: stenoses and asymmetry of jugular veins common in non-MSers – are these abnormal?

Are venous asymmetry’s specific to MS? #MSBlog #MSResearch #ResearchSpeak “The descriptive study below describes frequent asymmetries in the internal jugular veins (IJV) of non-MSers. It is a pity this was not compared to another control group, in particular a group of MSers. In my experience from looking at 1000’s of scans is that asymmetry in blood vessels, including arteries...

Meta analysis of the Week.

Zhang P, Wang R, Li Z, Wang Y, Gao C, Lv X, Song Y, Li B. The risk of smoking on multiple sclerosis: a meta-analysis based on 20,626 cases from case-control and cohort studies. PeerJ. 2016;4:e1797.  Background. Multiple sclerosis (MS) has become a disease that represents a tremendous burden on patients, families, and societies. The exact etiology of MS is still unclear, but it is believed...

ClinicSpeak: time to focus on hand function to measure worsening MS

How important is arm function, speech and swallowing to you? #MSBlog #MSResearch #ClinicSpeak “It is clearly  time to rethink how we do progressive, or worsening, MS trials (I am trying to move away from using the term progressive). The days of relying on the EDSS to measure the impact of worsening/progressive MS are going fast. The study below shows that when using the EDSS-Plus to...

The eye as a predictor of brain activity

Martinez-Lapiscina EH, Arnow S, Wilson JA, Saidha S, Preiningerova JL, Oberwahrenbrock T, Brandt AU, Pablo LE, Guerrieri S, Gonzalez I, Outteryck O, Mueller AK, Albrecht P, Chan W, Lukas S, Balk LJ, Fraser C, Frederiksen JL, Resto J, Frohman T, Cordano C, Zubizarreta I, Andorra M, Sanchez-Dalmau B, Saiz A, Bermel R, Klistorner A, Petzold A, Schippling S, Costello F, Aktas O, Vermersch P, Oreja...

To boldly go where no man/woman has gone before

Proc Natl Acad Sci U S A. 2016 Mar 14. pii: 201519286. [Epub ahead of print] Identification of tissue-specific cell death using methylation patterns of circulating DNA. Lehmann-Werman R, Neiman D, Zemmour H, Moss J, Magenheim J, Vaknin-Dembinsky A, Rubertsson S, Nellgård B, Blennow K, Zetterberg H, Spalding K, Haller MJ, Wasserfall CH, Schatz DA, Greenbaum CJ, Dorrell C, Grompe M, Zick A, Hubert...

ResearchSpeak & GrandChallenges (7): how do anti-B cell therapies work?

Why are plasma cells potentially so important in MS? #ResearchSpeak #GrandChallenges #MSBlog #MSResearch It is clear that B cells play a central role in pathogenesis of MS, could the role for plasma cells be even bigger? 1. MS has not be seen in people who don’t make immunoglobulins due to rare genetic disorders (agammaglobulinaemia). 2. Oligoclonal IgG bands are invariably found...

Halting B cell Activation

Glatigny S, Wagner CA, Bettelli E. Cutting Edge: Integrin α4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis. J Immunol. 2016. pii: 1502614. [Epub ahead of print] The neutralization of integrin α4(Itga4) is currently used as treatment in multiple sclerosis. Although most studies have focused on its function on lymphocyte migration to the CNS, we have...

ClinicSpeak: frontloading risk; not one but two autoimmune diseases

Are you prepared to trade-in MS for one, or maybe two, other autoimmune diseases? #ClinicSpeak #MSBlog #MSResearch “Are you prepared to trade in your MS, on the promise of long-term remission, for a second autoimmune disease? If not alemtuzumab is not for you. The two case reports below are of two MSers who developed both autoimmune thrombocytopenia and autoimmune thyroid disease after...

Translate

Categories

Recent Posts

Recent Comments

Archives