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MouseDoctor

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    • This is just phase 1. It's main purpose is to test for safety. The results are very impressive for a phase 1 trial. All of the subjects have advanced disease and a few noticed improvement in their bladder symptoms. I think it's pretty good.

    • Until they have a trial….it is what it is and largely in the right direction but shows you some people continue to get worse and some people have no change. So if you are expecting miracoulous change (based on the Tisch website) then it is is clear this is not going to happen for every body.

  • Yeah I wouldn't say these results are wildly exciting but *any* sustained improvement in mobility/functioning is quite a big deal, right?

    My main concern would be, I'm so cynical that I doubt these improvements are actually real and enduring. A lot of people didn't respond at all. Those who did showed mild improvements and I wonder if there could be some placebo-esque improvement going on. That's purely me being cynical and jaded though!

    Nevertheless, this was only a phase 1 trial I think, so the research is still ongoing. Hopefully over the next few years and subsequent trials, we will see more data that confirms these improvements are real and enduring.

    Even if only half of patients see an improvement of just 1 EDSS, that's gotta be better than all patients seeing no improvement whatsoever!

    If this was on the NHS I'd probably be willing to give it a try.

    • Patient 3 went from EDSS 3.5 to 1.5 after 6 months.This looks like the only low EDSS in the study all others are 6-8.5 and had minimal to no improvement.
      Clearly this is going to work best on low EDSS patients.
      Tragedy is that someone who is now EDSS 3.5 will probably
      be a 6-7 by the time this becomes available and by then it won't work for them.

    • I believe somebody is doing this in Israel – but not for MS, but for spinal cord injury

    • I believe MS lesions located on the spine are spinal cord injuries. My point is, there are many degrees of damage to the CNS, traumatic as well as non-traumatic.

  • Yes stem cell therapies are in their infancy but I applaud any researcher for their drive in finding an effective treatment for progressive disease. As a patient with spms, I am tired of watching the pages of the calendar turn with no real hope. But also I am encouraged that some share this frustration and are actively tackling progression. To the people at Tisch MS Center….keep up the good work.

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