ArchiveApril 2016

Relapses matter- Don’t have them and save brain

Contribution of different relapse phenotypes to disability in multiple sclerosis.Stewart T, Spelman T, Havrdova E, Horakova D, Trojano M, Izquierdo G, Duquette P, Girard M, Prat A, Lugaresi A, Grand’Maison F, Grammond P, Sola P, Shaygannejad V, Hupperts R, Alroughani R, Oreja-Guevara C, Pucci E, Boz C, Lechner-Scott J, Bergamaschi R, Van Pesch V, Iuliano G, Ramo C, Taylor B, Slee M...

Eyes a window of progressive MS in the brain

Petracca M, Cordano C, Cellerino M, Button J, Krieger S, Vancea R, Ghassemi R, Farrell C, Miller A, Calabresi PA, Lublin F, Inglese M. Retinal degeneration in primary-progressive multiple sclerosis: A role for cortical lesions? Mult Scler. 2016. pii: 1352458516637679. [Epub ahead of print] BACKGROUND:Retinal atrophy in multiple sclerosis (MS) is secondary to optic nerve focal...

Time to put Kir4.1 as a major autoimmune target to bed…it isn’t

Pröbstel AK, Kuhle J, Lecourt AC, Vock I, Sanderson NS, Kappos L, Derfuss T. Multiple Sclerosis and Antibodies against KIR4.1. N Engl J Med. 374:1496-8. Chastre A, Hafler DA, O’Connor KC. Evaluation of KIR4.1 as an Immune Target in Multiple Sclerosis. N Engl J Med. 2016 14;374(15):1495-6. The search for specific autoantibodies in patients with multiple sclerosis has been an area of...

What’s in a name.?..Is PPMS on its way out, or have treatment options made a change for the better?

Westerlind H, Stawiarz L, Fink K, Hillert J, Manouchehrinia A. A significant decrease in diagnosis of primary progressive multiple sclerosis: A cohort study. Mult Scler. 2016. pii: 1352458516643394. [Epub ahead of print] BACKGROUND: Several reports indicate changes to prevalence, incidence, female-to-male ratio in multiple sclerosis. Diagnostic criteria, course definitions and clinical management...

Dimethyl fumarate does not control immunity via an effect on Nrf2

Schulze-Topphoff U, Varrin-Doyer M, Pekarek K, Spencer CM, Shetty A, Sagan SA, Cree BA, Sobel RA, Wipke BT, Steinman L, Scannevin RH, Zamvil SS.Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2.Proc Natl Acad Sci U S A. 2016 pii: 201603907. [Epub ahead of print] Dimethyl fumarate (DMF) (BG-12, Tecfidera) is a fumaric acid ester (FAE) that was advanced...

Pint of Science

#MSresearch @ #Pintofscience Pint of Science is an opportunity to go listen to local Scientists present their research in a local pub in UK, USA, France Spain, Austria, South Africa. Italy Australia, Canada and Brazil  Pint of Science website Click Here) This is occurring all round the UK and even in London So when offered the chance to have a Pint Surprise, Surprise I said Yes  ...

Tregs to the rescue

Eliseeva DD, Lifshits GV, Lokhonina AV, Zhdanov DD, Zavalishin IA, Bykovskaya SN. The treatment by expanded ex vivo autologous regulatory T-cells CD4+CD25+FoxP3+CD127low restores the balance of immune system in patients with remitting-relapsing multiple sclerosis]. Zh Nevrol Psikhiatr Im S S Korsakova. 2016;116(2. Vyp. 2. Rassejannyyj skleroz):54-62. Russian. AIM:To assess clinical efficacy and...

Common sense is not so common – the role of education in cognition

Front Neurol. 2016 Mar 29;7:46. doi: 10.3389/fneur.2016.00046. eCollection 2016. Influence of Formal Education on Cognitive Reserve in Patients with Multiple Sclerosis. Luerding R, Gebel S, Gebel EM, Schwab-Malek S, Weissert R. Abstract The concept of cognitive reserve (CR) and its influence on cognitive impairment has attracted increasing interest. One hundred twenty-eight patients with multiple...

Salt Intake is Not Related in Children

McDonald J, Graves J, Waldman A, Lotze T, Schreiner T, Belman A, Greenberg B, Weinstock-Guttman B, Aaen G, Tillema JM, Hart J, Lulu S, Ness J, Harris Y, Rubin J, Candee M, Krupp LB, Gorman M, Benson L, Rodriguez M, Chitnis T, Mar S, Barcellos LF, Laraia B, Rose J, Roalstad S, Simmons T, Casper TC, Waubant E. A case-control study of dietary salt intake in paediatric-onset multiple sclerosis...

Intrathecal Rituximab is rubbish for killing CNS B cells, but works a treat for baclofen

Topping J, Dobson R, Lapin S, Maslyanskiy A, Kropshofer H, Leppert D, Giovannoni G, Evdoshenko E. The effects of intrathecal rituximab on biomarkers in multiple sclerosis. Mult Scler Relat Disord. 2016;6:49-53 OBJECTIVES:Clinical trials of IV-rituximab have proved successful. It is unclear whether intrathecal (IT)-rituximab is more efficacious at lower doses. We examine its effects on B...

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