ArchiveMay 2016

Chronic pain – Wile E. Cyote style

Chronic pain disrupts the reward circuitry in multiple sclerosis Daniela Seixas, Jacqueline Palace and Irene Tracey. European Journal of Neuroscience. DOI: 10.1111/ejn.13272. Abstract Pain commonly affects multiple sclerosis (MS) patients, and has the potential to become chronic and burden an already damaged central nervous system. Imaging studies are providing insights into brain restructuring...

Is failure of an arm of MS SMART on the cards?

Zhang T, Kingwell E, De Jong HJ, Zhu F, Zhao Y, Carruthers R, Petkau J, Gustafson P, Oger J, Tremlett H. Association between the use of selective serotonin reuptake inhibitors and multiple sclerosis disability progression. Pharmacoepidemiol Drug Saf. 2016 May 23. doi: 10.1002/pds.4031. [Epub ahead of print] BACKGROUND:Benefits of selective serotonin reuptake inhibitors (SSRIs) in modifying the...

Drugs Studies from the AAN

ProfG on CLAD and why he thinks it will come back Clinical efficacy of cladribine tablets in patients with relapsing-remitting multiple sclerosis (RRMS): final results from the 120-week phase IIIb extension trial to the CLARITY study (Poster 3.028). Authors: Gavin Giovannoni, Giancarlo Comi, Stuart Cook, Peter Rieckmann, Kottil Rammohan, Per Soelberg-Sorensen, Patrick Vermersch, E. Martin and...

Saving Animals is the name of the game, but is the Masterchef approach to Science going to be Counterproductive

Prof B presented at this weeks nights “Pint of Science ”  offering in London in the Beautiful Mind section It was nothing to do with potatoes as shown in the advert above. but a Journey of Discovery that started with an unlikely observation in a Beetle (Cow pea weevil) and ended in MS. ProfB presented the group’s lastest findings in MS to a public audience. He asked...

Clinical trials from three different perspectives

This post coincides with International Clinical Trials Day which is celebrated each year around the world, on or around the 20 May to commemorate the day that James Lind started his famous trial. This week, across the Barts Health NHS Trust site a number of activities are taking place to educate, raising awareness and celebrate some of the brilliant research going on in our area. Our contribution...

Tracing your lesions through the MR Myelinoscope – news from the imaging department

Longitudinal Observation of Individual Multiple Sclerosis White Matter Lesions Using Quantitative Myelin Imaging Kitzler HH, Köhler C, Wahl H, Eisele JC, Deoni SC; Rutt BK, Ziemssen T, Linn J.  Poster # 1282, 24th annual meeting of ISMRM One of you recently asked the question whether lesions on MRI can disappear, and I said yes they can, and that this has to do with several factors including...

We’re redefining our Mojo

Anyone for a Mojito cocktail? That was one recommendation. #MSBlog #MSResearch #Mojo We’re back! Following one week of painful – albeit self-inflicted – soul searching we’ve now discussed the positioning of the blog. Thank you for all the feedback (positive and not-so positive) whilst the blog was suspended. We reviewed ALL of your comments, and felt very much encouraged to resume blogging...

Under starting orders, Rebound of Fingolimod Withdrawal

ProfG recently posted on rebound disease activity after fingolimod  based on the this paper Rebound Syndrome in Patients With Multiple Sclerosis After Cessation of Fingolimod Treatment. Hatcher SE, Waubant E, Nourbakhsh B, Crabtree-Hartman E, Graves JS. JAMA Neurol. 2016 May 2. doi: 10.1001/jamaneurol.2016.0826. [Epub ahead of print] So hot on its heels comes this oneDavion JB, Cambron M...

You are what you eat. Diet and Disease

Libbey JE, Doty DJ, Sim JT, Cusick MF, Round JL, Fujinami RS. The effects of diet on the severity of central nervous system disease: One part of lab-to-lab variability. Nutrition. 2016 Jan 21. pii: S0899-9007(16)00039-3.  OBJECTIVE:Many things can impact the reproducibility of results from laboratory to laboratory. For example, food from various sources can vary markedly in...

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