Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS). The high costs, inconvenient administration, and side effects of current Food and Drug Administration (FDA)-approved drugs often lead to poor adherence to the long-term treatment of MS. Molecular hydrogen (H2) has been reported to exhibit anti-oxidant, anti-apoptotic, anti-inflammatory, anti-allergy, and anti-cancer effects. In the present study, we explored the prophylactic and therapeutic effects of hydrogen-rich water (HRW) on the progress of experimental autoimmune encephalomyelitis (EAE), the animal model for MS. We found that prophylactic administration of both 0.36mM and 0.89mM HRW was able to delay EAE onset and reduce maximum clinical scores. Moreover, 0.89mM HRW also reduced disease severity, CNS infiltration, and demyelination when administered after the onset of disease. Furthermore, HRW treatment prevented infiltration of CD4+ T lymphocytes into the CNS and inhibited Th17 cell development without affecting Th1 cell populations. Because HRW is non-toxic, inexpensive, easily administered, and can readily cross the blood-brain barrier, our experiments suggest that HRW may have great potential in the treatment of MS.
We are critisized for suggesting that pharma can and do produce drugs to treat MS that work (for some people with MS). Here is a non-pharma approach in EAE. Yep water. In this study you have hydrogen rich water, which can be made by placing a metallic magnesium stick into drinking water. However, in this case it
So before you rush off of get some.
Remember in EAE a good DMT can eliminate disease not amelirorate it.
Part II What was found?
Group Incidence Time of onset Maximum score
Control 14 of 15 11.1 (± 0.9) 3.28 (± 0.5)
(0.36 mM) 12 of 15 12.1 (± 0.4).94 (± 0.16)
(0.89 mM) 12 of 15 13.7 (± 0.6), 1.75 (± 0.27),
In the same paradigm it would be 0/15 if you gave the animals fingolimod.
It says “All animal experiments were performed in adherence with the National Institutes of Health Guidelines on the Use of Laboratory Animals and approved by the Second Military Medical University Committee on Animal Care”.
Did the first committee get canned for actually supporting the ethical use of animals :-(.
Pop Science or Plop science?:-(